2015
■Human pluripotent stem cells(hPSC)Site-specific control and neurological disease models derived from nerve cells（Stem Cell Reports.）2015.11.４
Imaizumi K, Sone T, Ibata K, Fujimori K, Yuzaki M, Akamatsu W, Okano H. Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes. Stem Cell Reports 5:1-13, 2015.
Imaizumi K, Sone T, Ibata K, Fujimori K, Yuzaki M, Akamatsu W, Okano H. Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes. Stem Cell Reports 5:1-13, 2015.
It is the job of the university fifth grade Imaizumi Mr. went in Okano Research。Ibata of Yuzusakiken gave a joint research in electrophysiology assays。
■Orphan receptor RORαregulates multiple aspects of dendeite development of cerebellar Purkinje cells（J Neurosci）2015.9.9
Takeo YH, Kakegawa W, Miura E, Yuzaki M. RORα Regulates Multiple Aspects of Dendrite Development in Cerebellar Purkinje Cells In Vivo. J Neurosci 35:12518-12534, 2015.
Takeo YH, Kakegawa W, Miura E, Yuzaki M. RORα Regulates Multiple Aspects of Dendrite Development in Cerebellar Purkinje Cells In Vivo. J Neurosci 35:12518-12534, 2015.
By making full use of the intrauterine electroporation method and inducible knockdown / knockout method、Cell movement of the transfer factor RORalpha developmental period、Removing dendrites formed、Spinous process development、This paper was the first time revealed that further with the dendrites and the spinous process maintenance, such as various functions of the post-mature。
■Complement family molecules C1qL1 is required for the formation, maintenance, and learning synapse（Neuron）2015.1.21
Kakegawa W, Mitakidis N, Miura E, Abe M, Matsuda K, Takeo YH, Kohda K, Motohashi J, Takahashi A, Nagao S, Muramatsu SI, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M. Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum. Neuron. 85:316-329, 2015.
http://www.cell.com/neuron/abstract/S0896-6273%2814%2901101-5
Kakegawa W, Mitakidis N, Miura E, Abe M, Matsuda K, Takeo YH, Kohda K, Motohashi J, Takahashi A, Nagao S, Muramatsu SI, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M. Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum. Neuron. 85:316-329, 2015.
http://www.cell.com/neuron/abstract/S0896-6273%2814%2901101-5
in recent years、Failure of nerve circuit that was the foundation of the synapse as one of the causes of developmental disabilities and mental illness has been suspected。However formed so as to how synapses、maintain、Or about what is removed、Has been left unresolved points are numerous。In this study、Experiments using a mouse、A protein that nerve cells are called C1ql1 to secrete、The correct synapse in the cerebellum during postnatal development was found to strengthen selectively。Also、Upon removal of the C1ql1 after mature、Synapse is lost once formed、Is that the motor learning by the cerebellar circuit is significantly impaired was found。Similar to the protein in C1ql1 is also present in various brain regions other than the cerebellum、It thought to function in each of the neural circuit。For this reason、The results of this research、It is expected to be of use in the therapy method development and cause elucidation of memory impairment and mental illness。
This study、As part of the JST of CREST research、Sakimura Kenji professor of Niigata University、Masahiko Watanabe Professor of Hokkaido University、It is what was done in collaboration with Dr. Radu Aricescu of the UK Oxford University。