Interview-kun's paper "C1ql1-Bai3 signaling is necessary for climbing fiber synapse formation in mature Purkinje cells in coordination with neuronal activity” was published in Molecular Brain magazine。Cerebellar Purkinje cells form multiple climbing fibers and synapses when young、Unnecessary synapses are pruned during development, except for one climbing fiber。In this paper、climbing fiber：1 Purkinje cell：1Even in the mature cerebellum, which has established the control mode of、By increasing the expression of C1ql1 and Bai3、Purkinje cells create multiple climbing fibers and synapses again、Climbing fibers usually branch in the anterior-posterior direction,、Newly formed synapses originate from branches of climbing fibers that diverge in the medial-lateral direction、They discovered that the presence of electrical activity in climbing fibers and Purkinje cells is necessary for new synapse formation.。Even when the GluD2 glutamate receptor is knocked out after maturation,、It is known that the internal and external branches of multiple climbing fibers form synapses with Purkinje cells.、We also found that this phenomenon is also dependent on C1ql1-Bai3 signaling。

The 158th Brain Club was held on July 14th。This time, Professor Yusaku Iwasaki of Kyoto Prefectural University gave a lecture titled "Direct effects of food-related factors on vagal afferent nerves and their relationship to eating, metabolism, and mental functions."。
It was a semi-closed event that was held onsite only.、A lively discussion took place over time。

The 157th Brain Club was held on June 15th。This time, Professor Imayoshi from Kyoto University.、This is a double feature by Mr. Michikawa.。
・Dr. Itaru Imayoshi (Graduate School of Life Sciences/Institute of Medical Biology, Kyoto University) "Optogenetic analysis of transcription factor expression dynamics that determines the differentiation fate of neural stem cells"
・Dr. Takaaki Michikawa (Institute of Biomedical Sciences, Kyoto University) "Technology and prospects for observing the whole brain"
It was held on-site only.、Enthusiasm for science by both professors led to a lively discussion.。

alreadyGuidanceHowever, Yuzu Lab has been selected for the International Joint Research Acceleration Fund (International Leading Research) ``Multidimensional analysis of memory mechanism – from nm to mesoscale / millisecond to day scale''。Next 7 years (up to 10 years)、We will work on international exchange and development of young researchers, mainly postdocs and graduate students.。

postdocs and graduate students、Max Planck Florida Institute of Neuroscience (USA) and Interdisciplinary Institute of Neuroscience using this framework (IINS) -Short-term and mid-term study abroad at Bordeaux Neurocampus (France)。Interested graduate students and postdocs should visit Grant's website。the poster isInternational Leading Research Poster 230613

At the 156th BrainClub、Dr., Laboratory for Learning and Memory Neural Networks, RIKEN Center for Brain Science. Joshua P. We invited Dr. Johansen (5/10)(Wed) 16:00~17:30）。The title is "Constructing Emotional Representations in the Brain"。sensory input、physiological state of the body、and the cognitive component、Mechanisms controlling memory formation via emotion、He talked about hierarchical and distributed neural network models with recent findings.。The day was held in a hybrid format, and lively discussions took place over time.。

2022Annual (54th) Naito Memorial Prize for Science Promotionwas awarded to Yuzuzaki。3The presentation ceremony was held at the Industrial Club of Japan on the 16th of the month.。
The award-winning research theme is "Elucidation of the molecular mechanisms that control functional and structural synaptic plasticity"。Thank you to the collaborators, Yuzu Lab's colleagues and OB。

34 days from 6th to 9th of the month、Okinawa Institute of Science and Technology Graduate University (OIST))Meeting after a long time atWorkshop “Nervous System Assembly”It has been made。Poster presentation + Flash talk by Oishi, a graduate student from Yuzaki Lab、Yuzuzaki gave a talk。Blessed with good weather, a lively discussion took place.。                                                                                       Tomi Yoshida of OIST was the organizer。

In the 155th BrainClub、We invited Dr. Thomas Chater from the RIKEN CBS Synaptic Plasticity and Circuit Regulation Research Team (2/15(Wed) 16:00~17:30）。The subject was "Towards a logic of homo- and heterosynaptic dynamics following plasticity」です。from recent research、A phenomenon called "Heterosynaptic plasticity" has been found in which plasticity occurs in neighboring synapses when a plasticity-inducing stimulus is applied to a specific synapse.。For Chater teacher this time、Observation of spine morphology and Ca using hippocampal slice culture and two-photon microscopy²⁺learned from imaging、He gave a lecture on interactions between spines that cause heterosynaptic plasticity.。Regarding the spatio-temporal control mode between synapses、A heated discussion took place, including unpublished data.。Commemorative photo @ seminar room with members of Yuzuzaki Lab after the lecture (upper photo)。In the center is Mr. Chater, the performer.。It was a raging BrainClub rush。Hope next time。(Press conference)

 University of California (UC Irvine, America)Dr. Kei Igarashi from、The 154th BrainClub was held (2/6(month) 17:30~19:00）。The title of the lecture was "Associative memory formation mechanism by dopamine and its failure in Alzheimer's disease"。The target is the formation and maintenance process of memory that is established based on olfactory information.、optogenetics andin vivoWe have clarified so far using electrophysiological techniques、He gave a lecture on the brain circuitry that controls memory.。Also、What kind of breakdown of brain circuit mechanism occurs in memory disorder of Alzheimer's disease?、Talk about the latest findings, including unpublished data.、A lively question-and-answer session ensued。

The above photo is a commemorative photo taken after the lecture.。In the center is Igarashi-sensei (next to Yuzuzaki-sensei)。A lot of "recruits" of Yuzuzaki Lab are also reflected。I was careless and the update didn't catch up、excuse me (interview)

On November 10, 2018, Keio University launched the World Premier International Research Center Initiative (WPI).)Adopted as a base for、2The kick-off meeting was held on March 3rd.。(Human Biology x MicroBiome x Quantum computing = Bio2Q)As、Focusing on the Microbiome、How human homeostasis is controlled by mucosal epithelium, immunity, nerves, metabolism, etc.、A 10-year project that aims to elucidate using quantum computing with AI。Under Director Honda、Yuzuzaki as the representative of the neural control team、I will also participate as a special assistant to the center director.。

Welcome Dr. Ingo Greger from MRC Molecular Biology Laboratory (UK)、1The 153rd BrainClub was held on Friday, March 20th.。The title is "Mechanisms underlying AMPA receptor modulation and synaptic localization"。AMPA receptors accumulated at postsynaptic sites play a central role in fast information transmission between neurons via excitatory synapses.。For Ingo-sensei this time、Clarified using cryo-electron microscopy and electrophysiological analysis、The functional control mechanism of AMPA receptors brought about by differences in constituent subunits and auxiliary subunits、Please tell us about your latest findings.、Lively discussions took place。

The photo above is a commemorative photo taken after the lecture@Yuzaki lab seminar room。Ingo-sensei is central。Next to Yuzuzaki-sensei。The Seminar room has become beautiful Yo (Conference)

2022JSPS International Joint Research Acceleration Fund (International Leading Research) to “Multidimensional Analysis of Memory Mechanisms”–from nm to mesoscale/millisecond to day scale”.。Bordeaux Neuroscience Institute（Dr. Choquet）、Max Planck Florida Institute（Drs. Yasuda & Fitzpatrick) and Japan.。Represented by Professor Yasunori Hayashi of Kyoto University、At domestic bases of Keio University, NIG, Niigata University, and the University of Tokyo、Next 7 years (up to 10 years)、We will work on international exchange and development of young researchers, mainly postdocs and graduate students.。

For postdocs and graduate studentsSupport for short-term and long-term study abroadPlease spread the information so that you can watch it.。AlsoSupport for young researchers when they become independentYou can do it, so please make the most of your chance.。