How to covalently chemically label proteins without genetic manipulation、A powerful method for analyzing receptors。However、Selective target receptor labeling in the brain has not yet been established。there、In this research led by Mr. Nonaka of Kyoto University's Hamachi Laboratory,、using ligand-directed chemical reactions、We show that synthetic probes can selectively bind to target endogenous receptors in the brain of living mice。Kakegawa of Yuzaki Lab、As part of the joint research between CREST and ERATO, Arai、In this study, we showed that chemical labeling does not change receptor function.。Proc Natl Acad Sci USA. 121:e2313887121, 2024

GABA acts as a ligand for GluD1、A paper by Pierre Paoletti, Radu Aricescu et al. that reported that it promotes long-term potentiation of inhibitory synapses.（Science 2023)Mr. Ito wrote an explanatory article, Research Highlight, about (Ito and Yuzaki, Cell Research)。

Sponsored by Dept Biomedicine at the University of Bergen, NorwayAt BBB Seminar、Yuzaki gives a lectureThe we。It's a polar night and there's almost no daylight.、It was a rare heavy snow day even in Bergen, but we enjoyed a lively discussion.。

The 161st Brain Club welcomed Dr. Takero Saneyoshi (Kyoto University)。The title of the presentation was ``Cofilin inside the dendritic spine exhibits molecular activity through liquid-liquid phase separation."forming a sexual gradient"。Long-term potentiation (LTP) is considered a fundamental process of memory learning.) paper、Structural changes occur in which dendritic spines become larger over time, but the mechanism was not fully understood.。Dr. Saneyoshi found that the temporarily increased Ca concentration within the spine、Continuously activates calmodulin kinase (CaMKII) and its downstream enzymes.、As a result, the mechanism that changes the actin skeleton has been successfully clarified.。We all listened with great interest.。

Yuzaki will enjoy the honor of receiving the Medal with Purple Ribbon in the fall of 2023.。The Purple Ribbon Medal、Inventions and discoveries in the fields of science and technology、This is a badge of honor given by the country to people who have made outstanding achievements in academics, sports, and the arts.。The transmission ceremony and audience were held on November 13th.。The photo shows Machi Tawara representing the recipients at the ceremony.。This award was given in recognition of my achievements in the field of neuroscience.、of course、I would like to thank all the staff, postdocs, graduate students, technicians, secretaries, and many co-researchers who have worked with me thus far.。I am grateful for the congratulatory telegrams and emails I received from many people.。

10Held in Singapore on March 30th-31st、”A symposium on Neuroscience of Dementia“attended、Yuzaki gave a Keynote lecture。Another Keynote lecturer was Professor Hee-Sup Shin from South Korea.。This symposium is a group study similar to AMED in Japan.、It was the culmination of five and a half years of major grant research into dementia led by Professor George Augustine of Lee Kong Chian School of Medicine.。Additionally, on October 31st, Duke-NUS (National University of Sigapore)、We held a seminar。This was at the invitation of Mr. Nishiyama, who graduated from Yuzaki Lab and is independent at Duke=NUS (Photos here）。

26th-27th members of the Science Council of Japan(Part 2：Yuzaki was selected for Life Science)、10on the 2nd of the month、The appointment ceremony was held at the Prime Minister's Office.。6with a yearly term、Serve as vice chair of the 25th Basic Medical Science Committee。

The 5th UK-Japan Neuroscience Symposium was held in Wales, UK from August 31st to September 2nd.。Oral presentation by Mr. Shiozaki, a graduate student from Yuzaki Lab、Takasugi gave a poster presentation。Takasugi-kun was selected for the excellent poster award。Congrats!!It will be announced as an invitation to the next 6th Symposium as a prize.。In addition、Because Mr. Shiozaki was selected for the excellent poster award at the 4th UK-Japan Neuroscience Symposium、This time it was an oral invitation announcement.。This is a great achievement for the second consecutive year from Yuzaki Lab.。

The 160th Brain Club welcomed Dr. Teruyoshi Nakagawa (Vanderbilt University), who was temporarily returning to Japan.。The title is "Visualizing putative ions and water molecules in the ion conduction path of the AMPA receptor"。AMPA receptors are responsible for rapid excitatory transmission in the central nervous system、Elucidation of its structure and function is an important theme that expands the possibility of clinical application as well as basic science.。Dr. Nakagawa uses cryo-EM to、2.3Ca by resolution reaching Ų⁺The structure of transmissive AMPA receptor has been clarified。Interestingly, when a highly conserved gate (SYTANLAAF) in the AMPA receptor opens upon channel opening,、Ca in the same area²⁺you have told me to join。Probably Na⁺Along with inhibiting the influx of other ions such as、efficient Ca²⁺It is considered a mechanism for achieving transparency.、We all listened with great interest.。

The 159th Brain Club was held on August 10th with Dr. Mototaka Suzuki from the University of Amsterdam。Subject: General anesthesia decouples cortical pyramidal neurons: it's an update。Face-to-face only、And I was worried that there would be few people because it was during the summer vacation.、Many people participated and had lively discussions.。(I missed the timing to take a picture, so only some people are in the picture)。

Fund for the Promotion of International Joint Research (International Leading Research) "Multidimensional Analysis of Memory Mechanisms - From nm to mesoscale/millisecond to day scale"'s first Retreat in GotembaIt was held from August 5th to 8th at。Max Planck Florida Institute of Neuroscience (USA) and Interdisciplinary Institute of Neuroscience (IINS) -BordeauxNeurocampus(France) and domestic (Kyoto University, Keio University, Tokyo University, Niigata University, NIG) gathered many PIs, postdocs and researchers.、Discussions continued late into the night。Ms. Delina, who gave an oral and poster presentation from Yuzuzaki Lab, was selected as one of the three poster award winners.。Thank you for your visit。With the support of this grant, for the next 7 years (10 years if it passes the examination)、International exchange and joint research centered on graduate students, postdocs, and young researchers are expected to progress.。

Mr. Nozawa, who received his degree (Doctor of Medicine) in March this year,、2023Received the Toshihiko Tokizane Memorial Award for Outstanding Doctoral Research in Neuroscience at the Japan Neuroscience Conference in Sendai。Nozawa also attended the degree conferment ceremony held at Keio University in March.、Selected as a representative of the Graduate School of Medicine。Congratulations!。