This is a review article by Dr. Yuzaki published in The Special Issue of the Current Opinion in Neurobiology on "Synaptic function and regulation (April issue in 2011)To "、Review of Yuzusaki was published on C1ql1 family of molecules is a new synapse formation and maintenance factor Cbln1 and its related protein。Thing that summarizes the work so far of the laboratory。

From Kyoto Hirokawa Shoten、"Transport Zoom of the world - from the headwaters of the membrane transport studies to the future" was out。Is a book that covers the history of the study of channel transporter and its related molecules until recently topic。Yuzusaki has shared writing to the section of the ligand-gated channels of Chapter 2 ion channel。For details please Click here. 。

RIKEN Brain Science Institute (RIKEN-BSI)BSI-Seminar Series is the flagship seminar (BSS)Yuzu Saki gave a lecture at。6Month 9 days - we were given the opportunity to interact with researchers in many of BSI over the two days of the 10 days。

Matsuda (Keiko) and Yuzusaki was featured in the "Japanese researchers placed on the science."。

In the link below you can read the digital edition (article of Yuzusakiken is 28 pages)。

From “Japanese Scientists in Science 2010.” Reprinted with permission from AAAS.“

Keiko Matsuda's paper There are published in the European Journal of Neuroscience、In this issue Featured Article. It was chosen to。Sudhof Dr. told me to write a comment article。



It is a follow-up report of a strong synapse formation and maintenance molecule Cbln1 in the cerebellum, which we have already reported。Although last year's Science paper (2010), the postsynaptic receptors has reported that it is a GluD2、In this paper presynaptic side of the receptor Neurexin (Nrx)It is、In addition brain regions (hippocampus and cerebral cortex) other than the cerebellum any similar molecule (Cbln2 and GluD1)It reported that has a similar synapse formation action。Nrx is known as the gene responsible for autism、But as its receptor, such as Neuroligin and LRRTM it has been known、Nrx-Cbln1-GluD2 is、It is possible to control the synapse formation was found by an independent molecular mechanisms and these molecules。

Baby girl of the second child was born in Kakegawa Assistant Professor。It is 撫菜 (shepherd's purse) chan。Congrats!!

A paper by Kakegawa has been published in Nature Neuroscience (online edition 04 April).。Is a joint research with Kyushu University of Hamase Associate Prof.。

There are many different types of memory、Memory associated with motor skills such as a human of sports and playing a musical instrument activities、Cerebellum of neural circuits are involved。However、Unknown Many points about the molecular mechanisms that control the storage in the cerebellum synapse、For example, we do not know well why to reduced motor learning ability with age。

So far、By protein Cbln1 secreted by neurons in studies using mouse binds to the delta type 2 glutamate receptor (delta 2 receptor)、I had discovered that to control the synapse formation in the cerebellum。Nozawa-kun, together with Hayashi-san、By amino acid D- serine abundant in the cerebellum of juvenile mice bind to delta 2 receptor、To promote the movement memory and learning in the synapse、It was revealed in experiments。In fact D- where serine was prepared and analyzed a genetically modified mouse which can not bind to the delta 2 receptor、Movement memory and learning ability in juvenile life had been significantly reduced。

Binding model of the D- serine and delta 2 receptor、Also believed to be fitted to the people。This finding is、Thing to provide a useful knowledge in understanding the movement memory and learning process in the early childhood of people。Also、Delta 2 receptor is expressed throughout life、By controlling the D- serine pathway、future、There is a possibility that can efficiently to promote motor learning in adults。

Picked up in Yomiuri Shimbun、Nikkan Kogyo Shimbun、It was featured in such as Asahi newspaper children。

JST Press ReleaseHere。

The paper by Emi as the first authorhas been accepted by Neurochem ResNow and in press in。

This thesis has developed a new rapid blink conditioning protocol for the cerebellar motor learning function measurement。But it is scheduled to come out let me know after、The time being Congratulations。

Iijima-kun (now Univ Basel studying in Scheiffele Research) and Miura's co-authored papers have been published in the European Journal of Neuroscience magazine。
http://www3.interscience.wiley.com/journal/123389540/abstract

We used to go the expression and biochemical analysis of C1ql family molecules in the brain。C1q family molecules having a structure similar to that of Cbln1 is specifically expressed in a completely different brain regions and Cbln1、It was found to be secreted as multimeric。Possibility of C1ql family molecules also involved in synaptic function in these brain regions are suggested。

Assistant Professor Matsuda's paperScience Notes (April 16 号).。Hokkaido University of Ken Watanabe、It is a joint research with Ken Shigemoto of NIPS。

Cbln1 receptor delta 2 receptors on the postsynaptic (GluD2)It is、Cbln1-CluD2 complex was discovered for the first time that you have to control the maturation of presynaptic and postsynaptic to the bidirectional。

This paperScience STKEIt was selected as Editor's Choice in。Also it was featured in newspapers and Nikkei Sangyo newspaper Kyodo News system。JST's press releaseClick here. 。

Autophagy is a graduate student journal articles Kun Katsumata(IF:5.48)Now Accept to。This paper referred to as "auto-phagocytosis transchromosomic in nerve axons is retrograde transport to the activity-dependent by dynein"。It is a joint research with Mizushima teacher of Tokyo Medical and Dental University。
http://www.landesbioscience.com/journals/autophagy/article/11262/

Accumulation of swelling and autophagosomal of nerve cell axons have been known in a variety of neurodegenerative diseases and ischemic brain。But not little is known about the physiological significance and the dynamics of the auto phagocytosis transchromosomic in axon。Using live imaging techniques in this paper、Autophagosomes transchromosomic is being transported to the cell body by dynein motor from axon、The number of auto-phagocytosis transchromosomic in axon by glutamate stimulation was revealed for the first time that the increase。

Autophagy is a graduate student journal articles Kun Katsumata(IF:5.48)Now Accept to。This paper referred to as "auto-phagocytosis transchromosomic in nerve axons is retrograde transport to the activity-dependent by dynein"。It is a joint research with Mizushima teacher of Tokyo Medical and Dental University。
http://www.landesbioscience.com/journals/autophagy/article/11262/

Accumulation of swelling and autophagosomal of nerve cell axons have been known in a variety of neurodegenerative diseases and ischemic brain。But not little is known about the physiological significance and the dynamics of the auto phagocytosis transchromosomic in axon。Using live imaging techniques in this paper、Autophagosomes transchromosomic is being transported to the cell body by dynein motor from axon、The number of auto-phagocytosis transchromosomic in axon by glutamate stimulation was revealed for the first time that the increase。