Exchange of information between nerve cells takes place in the synapse。Long-term suppression of transmission efficiency of synaptic (LTD) is、Is the foundation process of learning and memory in the brain。In the cerebellum、Cerebellar granule cells by learning - LTD in synaptic transmission between Purkinje cells)It plays an essential role in memory to be involved in the movement that occurs (such as dexterity and timing)。LTD In general postsynaptic neurons、Caused by a reduction in the number of AMPA receptor to receive the glutamic acid。Features of cerebellar LTD is、It is to require delta type 2 glutamate receptor specifically present in Purkinje cells in addition to。The cause and mechanism had been left for many years remains a mystery。Finally succeeded in solving this mystery in this paper。Delta 2 receptors by controlling the phosphorylation state of the AMPA receptor、It was found that acts as a so-called master key to determine whether or not occur or LTD occurs。

In this study, Drs. Kohda and Kakegawa showed that the serine phosphorylation of AMPA receptors required prior dephosphorylation of the nearby tyrosine residue. By interaction with a tyrosine phosphatase, δ2 glutamate receptors regulated tyrosine dephosphorylation status of GluA2 to gate inducibility of LTD. These findings will provide better understanding of general mechanisms regulating AMPA receptor endocytosis during synaptic plasticity. This paper has been published in PNAS.。For Press releaseClick here. 。

2012Dr. Ishida's paper, whichappeared in Neuron has beenThere has been introduced in the Preview as paper should be noted in Developmental Cell magazine。

Read the Preview at: Choreographing the axo-dendritic dance. Dev Cell 23:923-924,2012.

Keiko Matsuda's paper, which was published in the European Journal of Neuroscience (EJN) in 2011 hasbeen selected asthe EJN most cited papers in 2011-12He was elected to。

The original articles is here→Matsuda K, Yuzaki M. Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions. Eur J Neurosci 33:1447-1461,2011

A degree in our laboratory、Will continue papers Aya Ishida was Gakushin Fellow of the (SPD) at Ken Okabe Tokyo University, Dr. (now the United States studying abroad)Neuron 志 (2012 年 11 月 号).。It is the result of joint research with the University of Tokyo Ken Okabe Ken Watanabe Hokkaido。

In the central nervous system、I do not know still much about how the synapse is going to be formed。In this study、By over time imaging using living neurons、It was to clarify this issue。The synapses between cerebellar granule cells and Purkinje cells、After postsynaptic structures (spine) of the previously formed、Presynaptic will be formed。Is Cbln1 molecules released from the granule cells、By binding to presynaptic Neurexin and postsynaptic GluD2、To induce the formation of small protrusions from presynaptic、It was found to form synapses front of the structure (the button)。

In this issue は”The Synapse” and. by M. Sheng, B.L. Sabatini and T.C. Sudohof, Cold Spring Harbor Press, 2012Read the。

Form of synaptic、function、plasticity、Over pathology and variety、Is a book by researchers of the first line of each field was written by。As advanced course after reading the textbook of neuroscience、If you are interested、We expect a large number of participants。We do not question the classroom inside and outside, universities inside and outside, job title, etc.。

10Than every Tuesday 18 am as a rule than the moon 30 days will be made in our department。Inquiry (TheKodaUp)

This year's Tokizane Prize has been awarded to Prof. Yuzaki.Tokizane Prize is established with a trust fund donated from Mme. Nobu Tokizane. Prof. Toshihiko Tokizane (1910~1973) was one of the prominent pioneer and ａ great promoter of brain science in Japan.It was won。The grant reward type は 35 back to Japan God 経 Science ConferenceIt was held at。

The 35th Japan at Neuroscience Symposium - gave a "control of neural plasticity by sugar chain towards the fusion of the sugar chain science and neuroscience."。It is co-sponsored by the new academic research "integrated operating principle elucidation of sugar chain that target the control of neurological function."。(Following titles omitted) the Chair is Yuzusaki and Nagoya-kadomatsu done、Miyata as Shinpojisuto Shinro (Kobe Kusuridai-biochemical / Kobe courtyard Medical · GCOE)、Sayaka Sugiyama (Niigata Institute Iha and neurological development)、Geoffrey T Swanson (Dept Mol Pharmacol and Biol Chem, Northwestern Univ), Radu Aricescu (University of Oxford), James Fawcett (University of Cambridge)The celebrated。

The functions of the brain、It was written to the general publicThis book, with a lot of color illustrations,There has been published。It is co-translation of the Uchiyama professor of Juntendo University。(Takeshi Yoro teacher translation supervisor)。Since the illustration has full entered、It is recommended as an introduction。

On July 13th, Prof. Yuzaki gave an invited talk in the meeting on "Brain Extracellular Matrix in Health and Disease (ECMNET)," held as a satellite event of Federation of European Neuroscience Societies (FENS) in Barcelona, Spain.There July 12 in Barcelona, ​​Spain as a satellite event of FENS - was held in 13 days。Yuzusaki has done an invited talk。

On April 26th, 2012, Prof. Yuzaki gave an invited talk in theInternational Graduate School of NeuroscienceYuzu Saki gave an invited talk in。”MOLECULAR MECHANISMS OF SYNAPTIC PROCESSING, Under the theme of FUNCTION AND DYSFUNCTION、This symposium over two days。Graduate students has been organized at the initiative。

On April 25, 2012, Prof. Yuzaki gave an invited talkat the DRA symposium on Receptor Structure and Function Yuzu Saki gave an invited talk in。

Dr. Kakegawa has awarded a Yong Scientist Award on his work on "Research on Glutamate Receptors in Regulation of Learning and Memory"from MEXT. It was won。congratulations。