165th Brain ClubCo-hosted with WPI-Bio2Qon October 30, 2024。Lecturer: Dr. Valentin Nägerl (Director), Institute of Anatomy and Cell Biology at the Medical Center of the University of Göttingen)We welcomed。The title of the presentation is "Super-resolution imaging of brain microanatomy"。Dr. Nägerl at Bordeaux University、Using STED microscopy, we have analyzed nanoscale structural changes associated with synaptic plasticity in real time.。in recent years、As a super-resolution observation technology for extracellular space、Super-resolution shadow imaging (SUSHI)was developed。This time, we listened to a very interesting talk about the technical aspects of super-resolution technology and new research applying SUSHI.。News on WPI-Bio2Q HPClick here. 2022。

The 164th Brain Club will be attended by Dr. Naoya Takahashi (IINS) on August 1, 2024., University of Bordeaux)。The title of the presentation is “Cortical tactile sensory processing – insights from mouse whiskers”。Modeled after the mouse primary sensory cortex、How is the threshold of tactile perception controlled by top down signals?、We also heard a very interesting story about how tool use is represented in the tactile cortex.。

The 47th Japan Neuroscience Conference (NEURO2024) was held from July 24th to 27th at the Fukuoka Convention Center.)At、Marin Shimizu, a fourth-year medical student, won the Junior Researcher Poster Award.。Congratulations! !

The paper states, ``There is no evidence that GluD receptors act as ligand-gated ion channels.''Published in Proc Natl Acad Sci magazineit was done。
Delta receptors (GluD1 and GluD2)、A member of the ionotropic glutamate receptor family、plays a central role in many neurodevelopmental and psychiatric disorders。GluD is、Not related to ion channel activity、By forming a tripartite complex across synapses with the secreted synaptogenic molecules Cbln and neurexin (Nrxn).、Controls synapse formation and maturation。On the other hand、in recent years、Only when GluD2 forms the Nrxn/Cbln/GluD2 complex、It was reported that it functions as an ion channel that responds to D-serine and glycine.。Nozawa-kun, together with Hayashi-san、We、Currents induced by D-serine and glycine in ectopic cells and neurons、Proved that GluD is not directly involved as an ion channel。This finding is、It makes an important contribution to the ongoing discussion on the function of GluD.。In collaboration with Pierre Paoletti laboratory、Mr. Ito and Laura Piot acted as first authors.。

kainate-type glutamate receptor (KAR)A paper on the function of synapse formation is available online.became。KAR is、through ionotropic and metabotropic effects.、Involved in various neuropsychiatric and neurological disorders。However、Compared to AMPA-type and NMDA-type glutamate receptors,、The biological properties of KARs remain unclear in many ways。In this research、K.A.R.、Completely separate from ion channels and metabotropic effects、We revealed that it acts as a synapse organizer that creates synapses themselves.。In joint research with the Juan Lerma laboratory in Spain.、Associate Professor Kakegawa and Ana Paternain are first authors。For Press releaseClick here. 。

A paper co-authored with Jaime de Juan-Sanz of the Sorbonne University in France was published.Published in Cell Reportsit was done。LGI1, like Cbln1, is a synaptogenic molecule that belongs to the class of "extracellular scaffold proteins."。On this occasion、Like Cbln1, LGI1 is also secreted in response to neural activity and promotes synapse formation.、It was also found that it suppresses glutamate release.。Interestingly, Cbln1 is tetanus toxin (TeNT)(VAMP1-3 independent)、Secreted by Syntaxin-4 and SNAP49-dependent SNAREs。In contrast, LGI1 secretion was partially inhibited by TeNT.、Because it does not depend on SNAP29、found to be released by separate SNARE complexes。Yuzaki Lab provided analysis technology for the SNARE complex developed by Ibata。

The 163rd Brain Club welcomed Dr. Masanori Matsuzaki (University of Tokyo School of Medicine) on April 30, 2024。The title of the presentation is "Functional dynamics of intercortical circuits and cortical-subcortical circuits governing behavior and cognition."。Using mice and common marmosets、In the evolution from rodents to primates、We study how cerebral cortical circuits and their functional dynamics change to realize higher-order behavior and cognition.、We heard about how the activity of the cerebral cortex is being elucidated by optical measurement and optical manipulation while performing a task with the head fixed.。

 Experimental Medicine Special Issue April 2024 “Neuroscience opened up by large-scale data and AI”A review article by Mr. Takano and Mr. Sogabe titled ``The shape of synapses elucidated by proximity labeling and expansion microscopy'' was published in。

Mr. Takano、Promoted as an independent associate professor in the field of brain function and molecular systems at Kyushu University Institute of Advanced Research and Biodefense Medicine.。Thank you for meeting me! Busy with moving work、We had a small celebration party with champagne.。

2024Yuzaki at the Imperial Hotel on March 3, 2017.Purple Ribbon Medal Celebrationwas held。Despite the sunny Sunday、Approximately 100 people gathered from all over the country.。Thank you very much again。(Tokyo Marathon was being held on the road in front of the hotel.)。）

It was canceled for a while due to the coronavirus pandemic.Physiology class reunion was held。In the first half, there was a lecture by Professor Ayako Ishida, who studied abroad at the Yuzaki Lab and now works independently as a team leader at RIKEN CBS.、In the second half, we moved to the restaurant park to exchange opinions.、And it ended with the regular chorus of young blood.。

in the central nervous system、Astrocytes clear glutamate from the synaptic cleft.、Achieves proper synaptic function。However、How does the astrocytic glutamate transporter GLAST function around synapses?、it was still unclear。In this paper、Cell adhesion molecule (DSCAM) expressed in Purkinje cells、By controlling the localization of GLAST expressed in Bergmann glia、Climbing fibers were shown to be involved in Purkinje cell synapse formation and cerebellar motor learning.。This is a huge amount of work done by Mr. Dewa of Hoshino Lab.。For the Yuzaki lab, Kakegawa was in charge of electrophysiological analysis and eye movement learning test.。Nat Commun. 15:458, 2024.

How to covalently chemically label proteins without genetic manipulation、A powerful method for analyzing receptors。However、Selective target receptor labeling in the brain has not yet been established。there、In this research led by Mr. Nonaka of Kyoto University's Hamachi Laboratory,、using ligand-directed chemical reactions、We show that synthetic probes can selectively bind to target endogenous receptors in the brain of living mice。Kakegawa of Yuzaki Lab、As part of the joint research between CREST and ERATO, Arai、In this study, we showed that chemical labeling does not change receptor function.。Proc Natl Acad Sci USA. 121:e2313887121, 2024

GABA acts as a ligand for GluD1、A paper by Pierre Paoletti, Radu Aricescu et al. that reported that it promotes long-term potentiation of inhibitory synapses.（Science 2023)Mr. Ito wrote an explanatory article, Research Highlight, about (Ito and Yuzaki, Cell Research)。

Sponsored by Dept Biomedicine at the University of Bergen, NorwayAt BBB Seminar、Yuzaki gives a lectureThe we。It's a polar night and there's almost no daylight.、It was a rare heavy snow day even in Bergen, but we enjoyed a lively discussion.。

The 161st Brain Club welcomed Dr. Takero Saneyoshi (Kyoto University)。The title of the presentation was ``Cofilin inside the dendritic spine exhibits molecular activity through liquid-liquid phase separation."forming a sexual gradient"。Long-term potentiation (LTP) is considered a fundamental process of memory learning.) paper、Structural changes occur in which dendritic spines become larger over time, but the mechanism was not fully understood.。Dr. Saneyoshi found that the temporarily increased Ca concentration within the spine、Continuously activates calmodulin kinase (CaMKII) and its downstream enzymes.、As a result, the mechanism that changes the actin skeleton has been successfully clarified.。We all listened with great interest.。

Yuzaki will enjoy the honor of receiving the Medal with Purple Ribbon in the fall of 2023.。The Purple Ribbon Medal、Inventions and discoveries in the fields of science and technology、This is a badge of honor given by the country to people who have made outstanding achievements in academics, sports, and the arts.。The transmission ceremony and audience were held on November 13th.。The photo shows Machi Tawara representing the recipients at the ceremony.。This award was given in recognition of my achievements in the field of neuroscience.、of course、I would like to thank all the staff, postdocs, graduate students, technicians, secretaries, and many co-researchers who have worked with me thus far.。I am grateful for the congratulatory telegrams and emails I received from many people.。

10Held in Singapore on March 30th-31st、”A symposium on Neuroscience of Dementia“attended、Yuzaki gave a Keynote lecture。Another Keynote lecturer was Professor Hee-Sup Shin from South Korea.。This symposium is a group study similar to AMED in Japan.、It was the culmination of five and a half years of major grant research into dementia led by Professor George Augustine of Lee Kong Chian School of Medicine.。Additionally, on October 31st, Duke-NUS (National University of Sigapore)、We held a seminar。This was at the invitation of Mr. Nishiyama, who graduated from Yuzaki Lab and is independent at Duke=NUS (Photos here）。

26th-27th members of the Science Council of Japan(Part 2：Yuzaki was selected for Life Science)、10on the 2nd of the month、The appointment ceremony was held at the Prime Minister's Office.。6with a yearly term、Serve as vice chair of the 25th Basic Medical Science Committee。

The 5th UK-Japan Neuroscience Symposium was held in Wales, UK from August 31st to September 2nd.。Oral presentation by Mr. Shiozaki, a graduate student from Yuzaki Lab、Takasugi gave a poster presentation。Takasugi-kun was selected for the excellent poster award。Congrats!!It will be announced as an invitation to the next 6th Symposium as a prize.。In addition、Because Mr. Shiozaki was selected for the excellent poster award at the 4th UK-Japan Neuroscience Symposium、This time it was an oral invitation announcement.。This is a great achievement for the second consecutive year from Yuzaki Lab.。

The 160th Brain Club welcomed Dr. Teruyoshi Nakagawa (Vanderbilt University), who was temporarily returning to Japan.。The title is "Visualizing putative ions and water molecules in the ion conduction path of the AMPA receptor"。AMPA receptors are responsible for rapid excitatory transmission in the central nervous system、Elucidation of its structure and function is an important theme that expands the possibility of clinical application as well as basic science.。Dr. Nakagawa uses cryo-EM to、2.3Ca by resolution reaching Ų⁺The structure of transmissive AMPA receptor has been clarified。Interestingly, when a highly conserved gate (SYTANLAAF) in the AMPA receptor opens upon channel opening,、Ca in the same area²⁺you have told me to join。Probably Na⁺Along with inhibiting the influx of other ions such as、efficient Ca²⁺It is considered a mechanism for achieving transparency.、We all listened with great interest.。

The 159th Brain Club was held on August 10th with Dr. Mototaka Suzuki from the University of Amsterdam。Subject: General anesthesia decouples cortical pyramidal neurons: it's an update。Face-to-face only、And I was worried that there would be few people because it was during the summer vacation.、Many people participated and had lively discussions.。(I missed the timing to take a picture, so only some people are in the picture)。

Fund for the Promotion of International Joint Research (International Leading Research) "Multidimensional Analysis of Memory Mechanisms - From nm to mesoscale/millisecond to day scale"'s first Retreat in GotembaIt was held from August 5th to 8th at。Max Planck Florida Institute of Neuroscience (USA) and Interdisciplinary Institute of Neuroscience (IINS) -BordeauxNeurocampus(France) and domestic (Kyoto University, Keio University, Tokyo University, Niigata University, NIG) gathered many PIs, postdocs and researchers.、Discussions continued late into the night。Ms. Delina, who gave an oral and poster presentation from Yuzuzaki Lab, was selected as one of the three poster award winners.。Thank you for your visit。With the support of this grant, for the next 7 years (10 years if it passes the examination)、International exchange and joint research centered on graduate students, postdocs, and young researchers are expected to progress.。

Mr. Nozawa, who received his degree (Doctor of Medicine) in March this year,、2023Received the Toshihiko Tokizane Memorial Award for Outstanding Doctoral Research in Neuroscience at the Japan Neuroscience Conference in Sendai。Nozawa also attended the degree conferment ceremony held at Keio University in March.、Selected as a representative of the Graduate School of Medicine。Congratulations!。

Interview-kun's paper "C1ql1-Bai3 signaling is necessary for climbing fiber synapse formation in mature Purkinje cells in coordination with neuronal activity” was published in Molecular Brain magazine。Cerebellar Purkinje cells form multiple climbing fibers and synapses when young、Unnecessary synapses are pruned during development, except for one climbing fiber。In this paper、climbing fiber：1 Purkinje cell：1Even in the mature cerebellum, which has established the control mode of、By increasing the expression of C1ql1 and Bai3、Purkinje cells create multiple climbing fibers and synapses again、Climbing fibers usually branch in the anterior-posterior direction,、Newly formed synapses originate from branches of climbing fibers that diverge in the medial-lateral direction、They discovered that the presence of electrical activity in climbing fibers and Purkinje cells is necessary for new synapse formation.。Even when the GluD2 glutamate receptor is knocked out after maturation,、It is known that the internal and external branches of multiple climbing fibers form synapses with Purkinje cells.、We also found that this phenomenon is also dependent on C1ql1-Bai3 signaling。

The 158th Brain Club was held on July 14th。This time, Professor Yusaku Iwasaki of Kyoto Prefectural University gave a lecture titled "Direct effects of food-related factors on vagal afferent nerves and their relationship to eating, metabolism, and mental functions."。
It was a semi-closed event that was held onsite only.、A lively discussion took place over time。

The 157th Brain Club was held on June 15th。This time, Professor Imayoshi from Kyoto University.、This is a double feature by Mr. Michikawa.。
・Dr. Itaru Imayoshi (Graduate School of Life Sciences/Institute of Medical Biology, Kyoto University) "Optogenetic analysis of transcription factor expression dynamics that determines the differentiation fate of neural stem cells"
・Dr. Takaaki Michikawa (Institute of Biomedical Sciences, Kyoto University) "Technology and prospects for observing the whole brain"
It was held on-site only.、Enthusiasm for science by both professors led to a lively discussion.。

alreadyGuidanceHowever, Yuzu Lab has been selected for the International Joint Research Acceleration Fund (International Leading Research) ``Multidimensional analysis of memory mechanism – from nm to mesoscale / millisecond to day scale''。Next 7 years (up to 10 years)、We will work on international exchange and development of young researchers, mainly postdocs and graduate students.。

postdocs and graduate students、Max Planck Florida Institute of Neuroscience (USA) and Interdisciplinary Institute of Neuroscience using this framework (IINS) -Short-term and mid-term study abroad at Bordeaux Neurocampus (France)。Interested graduate students and postdocs should visit Grant's website。the poster isInternational Leading Research Poster 230613

At the 156th BrainClub、Dr., Laboratory for Learning and Memory Neural Networks, RIKEN Center for Brain Science. Joshua P. We invited Dr. Johansen (5/10)(Wed) 16:00~17:30）。The title is "Constructing Emotional Representations in the Brain"。sensory input、physiological state of the body、and the cognitive component、Mechanisms controlling memory formation via emotion、He talked about hierarchical and distributed neural network models with recent findings.。The day was held in a hybrid format, and lively discussions took place over time.。

2022Annual (54th) Naito Memorial Prize for Science Promotionwas awarded to Yuzuzaki。3The presentation ceremony was held at the Industrial Club of Japan on the 16th of the month.。
The award-winning research theme is "Elucidation of the molecular mechanisms that control functional and structural synaptic plasticity"。Thank you to the collaborators, Yuzu Lab's colleagues and OB。

34 days from 6th to 9th of the month、Okinawa Institute of Science and Technology Graduate University (OIST))Meeting after a long time atWorkshop “Nervous System Assembly”It has been made。Poster presentation + Flash talk by Oishi, a graduate student from Yuzaki Lab、Yuzuzaki gave a talk。Blessed with good weather, a lively discussion took place.。                                                                                       Tomi Yoshida of OIST was the organizer。

In the 155th BrainClub、We invited Dr. Thomas Chater from the RIKEN CBS Synaptic Plasticity and Circuit Regulation Research Team (2/15(Wed) 16:00~17:30）。The subject was "Towards a logic of homo- and heterosynaptic dynamics following plasticity」です。from recent research、A phenomenon called "Heterosynaptic plasticity" has been found in which plasticity occurs in neighboring synapses when a plasticity-inducing stimulus is applied to a specific synapse.。For Chater teacher this time、Observation of spine morphology and Ca using hippocampal slice culture and two-photon microscopy²⁺learned from imaging、He gave a lecture on interactions between spines that cause heterosynaptic plasticity.。Regarding the spatio-temporal control mode between synapses、A heated discussion took place, including unpublished data.。Commemorative photo @ seminar room with members of Yuzuzaki Lab after the lecture (upper photo)。In the center is Mr. Chater, the performer.。It was a raging BrainClub rush。Hope next time。(Press conference)

 University of California (UC Irvine, America)Dr. Kei Igarashi from、The 154th BrainClub was held (2/6(month) 17:30~19:00）。The title of the lecture was "Associative memory formation mechanism by dopamine and its failure in Alzheimer's disease"。The target is the formation and maintenance process of memory that is established based on olfactory information.、optogenetics andin vivoWe have clarified so far using electrophysiological techniques、He gave a lecture on the brain circuitry that controls memory.。Also、What kind of breakdown of brain circuit mechanism occurs in memory disorder of Alzheimer's disease?、Talk about the latest findings, including unpublished data.、A lively question-and-answer session ensued。

The above photo is a commemorative photo taken after the lecture.。In the center is Igarashi-sensei (next to Yuzuzaki-sensei)。A lot of "recruits" of Yuzuzaki Lab are also reflected。I was careless and the update didn't catch up、excuse me (interview)

On November 10, 2018, Keio University launched the World Premier International Research Center Initiative (WPI).)Adopted as a base for、2The kick-off meeting was held on March 3rd.。(Human Biology x MicroBiome x Quantum computing = Bio2Q)As、Focusing on the Microbiome、How human homeostasis is controlled by mucosal epithelium, immunity, nerves, metabolism, etc.、A 10-year project that aims to elucidate using quantum computing with AI。Under Director Honda、Yuzuzaki as the representative of the neural control team、I will also participate as a special assistant to the center director.。

Welcome Dr. Ingo Greger from MRC Molecular Biology Laboratory (UK)、1The 153rd BrainClub was held on Friday, March 20th.。The title is "Mechanisms underlying AMPA receptor modulation and synaptic localization"。AMPA receptors accumulated at postsynaptic sites play a central role in fast information transmission between neurons via excitatory synapses.。For Ingo-sensei this time、Clarified using cryo-electron microscopy and electrophysiological analysis、The functional control mechanism of AMPA receptors brought about by differences in constituent subunits and auxiliary subunits、Please tell us about your latest findings.、Lively discussions took place。

The photo above is a commemorative photo taken after the lecture@Yuzaki lab seminar room。Ingo-sensei is central。Next to Yuzuzaki-sensei。The Seminar room has become beautiful Yo (Conference)

2022JSPS International Joint Research Acceleration Fund (International Leading Research) to “Multidimensional Analysis of Memory Mechanisms”–from nm to mesoscale/millisecond to day scale”.。Bordeaux Neuroscience Institute（Dr. Choquet）、Max Planck Florida Institute（Drs. Yasuda & Fitzpatrick) and Japan.。Represented by Professor Yasunori Hayashi of Kyoto University、At domestic bases of Keio University, NIG, Niigata University, and the University of Tokyo、Next 7 years (up to 10 years)、We will work on international exchange and development of young researchers, mainly postdocs and graduate students.。

For postdocs and graduate studentsSupport for short-term and long-term study abroadPlease spread the information so that you can watch it.。AlsoSupport for young researchers when they become independentYou can do it, so please make the most of your chance.。

Yuzaki gave a special lecture on January 21, 2023 at the 11th Neuro Conference Wakayama (Wakayama Medical University Kimiidera Campus)。Invited by Dr. Norimitsu Inoue, Department of Molecular Genetics, a leading expert in complement research。The photo is Professor Murai of the Department of Neurology, International University of Health and Welfare, another special lecturer.。

Core-to-core program symposium “Molecular Physiology of Neuronal Signaling” of the core-to-core program “Research Center for Interdisciplinary Neuronal Signaling” (Doshisha University, Free University of Berlin, IST, Austria, University of Copenhagen), Circuits and Behavior” January 12-14、Yuzu gave an invited talk at Doshisha University in Kyoto。

International Symposium from January 6th to January 9th, 2023 at Keio University Mita CampusNeurovascular Unit Conference 2023It has been made。Supported by the Japan-US Brain Research Cooperative Program、On the Japanese side, Prof. Hitoshi Nakahara, Department of Neurology, Keio University、On the US side, Mr. Ken Arai from MGH was the organizer.。Yuzuzaki gave a keynote speech。

Dr. Teruhiro Okuyama of the Institute for Quantitative Life Sciences, The University of Tokyo, visited us.、The 152nd BrainClub was held (12/23(Fri) 16:00~17:30）。The title of his presentation was "Neural Mechanisms of Social Memory in the Hippocampus"。How "social memory" is processed as information in the ventral hippocampus、Obtained using calcium imaging and optogenetics、He gave a lecture on the results of his research to date.。In addition, please introduce the latest data on the brain representation mechanism of life and death.、It was a lively time for discussion from beginning to end.、I thought it was good too.)。

The photo above is the usual after the lecture、Commemorative photo while holding my breath @Yuzuzaki Laboratory。Okuyama-sensei is next to Yuzuzaki-sensei.。I'll do my best to clean up~ Aye oh…(Press conference)

Small molecules administered to adults、As a new technology that visualizes how and where in the brain it is distributed like a snapshot、We have developed a method for immobilizing small molecules using paraformaldehyde, which is often used in tissue fixation.。by this method、metabotropic glutamate receptor mGlu1、AMPA-type glutamate receptor、Succeeded in visualizing the localization pattern of dopamine receptors after ligand administration。This research was supported by ERATO/CREST.、In collaboration with Nagoya University Seichu Lab、published in Chemit was done。

Science Digest、Human Frontier Science Program (HFSP)is a new publication of。In HFSP-supported research、The most notable scientific achievements are highlighted。Commemorative first issue was published、We are the German Center for Neurodegenerative Diseases(DZNE)of Alexander Dityatev Laboratory、I was informed that the research I conducted with Dr. Radu Aricescu, Oxford University (at that time) has been published.。
HFSP home pagecan be read at。Also、excerpt isfrom hereavailable for download。

Goal 7 of the moonshot research and development project, "Understanding and application of intestinal bacterial action principle for extending healthy life expectancy" was adopted.、A kick-off meeting was held this time。Professor Kenya Honda is the project manager (PM))Is the、Yuzuzaki will participate as PM assistant and team leader of the "gut-brain linkage analysis team"。2022It is a research and development project for 6 years from FY 2019 (up to 9 years until FY 2030).。

Workshop 2022 was held to improve Presentation Skills。

Presentation skills for researchers、In addition to presenting research results and interacting with other researchers,、Returning research results to the general public、It is an essential technology when acquiring research funds。As an active brain science researcher,、Lectures and practical training were given by Professor George Augustine, who has a proven track record in teaching presentation methods.。
Graduate students belonging to Keio University Graduate School of Medicine, Graduate School of Pharmaceutical Sciences, and Graduate School of Science and Engineering、Young researchers participated。

This program is a WPI (Bio2Q)It is scheduled to be held as one of the joint graduate school programs (STaMP) in。

*Click here for Lecture videos→Open to those who belong to Keio University。

※※Lecture and Workshophere (photo)

Japan-U.S. brain. Brain Research Cooperative Program) and Core-to-Core Program supported symposium Development and Plasticity of the Brain was held in Ise-Shima between October 21st and 23rd。This meeting also commemorates the retirement of Professor Nobuhiko Yamamoto.。From the laboratory, Nozawa and Yuzu participated and Nozawa gave an oral presentation in English.。Photos from the symposiumClick here. 。

The 15th ChemBio Lecture hosted by the Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo was held on September 28 at Hongo Campus.、Yuzuzaki<gave a lecture。Another speaker is Professor Makoto Arita (Keio/RIKEN)、Associate Professor Ayumi Ishii (Teikyo University of Science)、Associate Professor Hiroshi Inaba (Tottori University)、It was Professor Hirohisa Omiya (Kyoto University)。

9The 4th event was held in Karuizawa from 19th to 22nd of the month. UK-At the Japan Neuroscience Symposium (sponsored by AMED-MRC)、Ms. Shiozaki, a graduate student, was selected for the best poster award。One presentation from Japan、One topic will be selected from the UK side.、The supplementary prize is the next 5th held in the UK UK-Invitation to oral presentation at Japan Neuroscience Symposium (travel expenses included)。Congratulations!

Ms. DILINA Tuerde、JSPS Special Fellow for Foreigners(PD)Adopted by。Congratulations!。For outstanding young researchers from other countries who have just obtained their Ph.D.、This program provides opportunities to engage in research at Japanese universities and other research institutes.。Only 8 people in all of Japan are employed in biological sciences.。

4th year doctoral student Kazuya Nozawa's dissertationOnline version of Neuron.。For Press releaseClick here. 2022。
by improving Expansion Microscopy (ExM), a high-resolution microscopy technique、Molecules that determine the individuality of synapses in the brain at the nano level (one millionth of a millimeter is one nanometer)：nm) revealed the structure of。

The neural network that underpins the functioning of the brain、Nerve cells are connected to each other by synapses。Various molecules that connect synapses are、Because it is concentrated in a narrow region of about 100 to 1000 nm in the synapse、Its detailed distribution cannot be observed with the resolution of conventional optical microscopes (approximately 200 nm).。there、Nozawa-kun, together with Hayashi-san、We further improved ExM, a technology that expands the specimen itself to about 1000 times its volume.、By optimizing for synaptic observation、For the first time, we succeeded in clarifying the structure and interrelationships of molecular groups that connect excitatory synapses in mouse neural networks at the nano-level.。According to the comment, 、A group of synaptic molecules that bind to neurexin (neurexin ligand)、It was discovered that they accumulate as units of ``nanodomains'' of several tens of nanometers each within synapses.。further、Depending on the type of neurexin present at the presynaptic site、It has been found that the arrangement of nanodomains of post-synaptic synaptic molecules and glutamate receptors is determined。
From the results of this research、The characteristics of synapses that support brain function、It turns out that each specialized synaptic molecule is created by interacting at the nano level.。These molecular groups have been reported to be associated with many psychiatric disorders and neurodevelopmental disorders.、It is expected that the results of this research will lead to an understanding of the pathogenesis of these diseases and the developmental mechanisms of normal neural circuits.。Taku Sogabe, a fifth-year medical student, also contributed greatly to the development of ExM.。

The 151st BrainClub presenters include:、We invited Dr. Takuya Sasaki from the Graduate School of Pharmaceutical Sciences, Tohoku University (Friday, July 15, 2022).、Face-to-face and web hybrid format)。heavy rain、Welcome to Keio University、He gave a lecture titled "Operating Principles of the Hippocampal Circuit Controlling Learning and Memory".。from the hippocampus and related brain regionsin vivoCan be deciphered from analysis results using multi-unit recording、Changes in neural activity during individual learning and memory、He talked about the research results obtained so far.。Also、Please also make a presentation on a new attempt to expand the recording target beyond the brain with the latest knowledge.、Lively discussions took place。

The photo is a commemorative photo taken after the lecture。Sasaki-sensei is in the center back row。Yuzusaki lab has many electrophysiology members。* There is no deep meaning in blurring the background (automatic adjustment of a certain Google smartphone used for trial)。After all, clean up a little ry (conference)

Assistant Professor Takano received the Young Investigator Award from Keio University School of Medicine in the 4th year of Reiwa.。Congratulations!

To understand how neural circuits in the brain work、There is a need for technology that selectively activates glutamate receptors, which are neurotransmitter receptors that control memory and learning.。In this research、While maintaining the original glutamate response ability、Developed a mutant glutamate receptor (metabolized type) activated by an artificial compound。We created mice that actually expressed this artificial glutamate receptor in a specific cell type.、It was shown that the administration of artificial compounds activates metabotropic glutamate receptors in a cell-type selective manner.。It is expected that the understanding of neural circuits will be accelerated by using this new technology "coordination chemogenetics method".。This research was supported by ERATO / CREST, Nagoya University Kiyonaka Lab.、This is a joint research with Kyoto University Hamaji Lab.。Click here for the paper

Brain Club 150th、Dr. Shogo Omae of Baylor College of Medicine gave a lecture on "Cerebellum Network Dynamics in Time Information Processing" (June 2, 2022).、web held)。Pressing for a review of the classical cerebellum computational principles、Regarding the new theory of "time information processing created by network dynamics of recurrent cerebellar circuits"、Experimental verification results using in vivo electrophysiology、About the dynamics generated from the artificial network model that imitates the cerebellar circuit、Lively discussions took place。

The commemorative photo is a screenshot of the PC screen (edited)。Looking at the camera ≠ Looking at the monitor?。even if、There is room for improvement in shooting timing control、Train the cerebellum (press conference)。

Invited Dr. Kenta Hagiwara of Allen Institute to the 149th Brain Club、Lecture on real-time online (April 27, 2022)。In addition to research results on neural circuit motifs that control the fear state of living things、Including the latest findings on the more general control of pleasant and unpleasant emotions、We had you discuss。Set in the new division "Allen Institute for Neural dynamics" of Allen, a new world、I'm looking forward to the future development of "In vivo physiology" (also a certain podcast?)。(Press conference)

The above image is a screenshot after the lecture、Hagiwara-sensei is the second from the left in the upper row (click the image to enlarge)。Excerpts from participants with camera ON。It may have overflowed off the screen due to the large number of participants.、Please pardon。* The secretariat is a "specification" that is not shown because it is a photographer.。

A translation of the 3rd edition of the original Brainbook "Mieru Brain" has been published.。It is a general book that explains the basic structure and function of the brain in an easy-to-understand manner with CG, illustrations and photographs.。It is a general book that explains the basic structure and function of the brain in an easy-to-understand manner with CG, illustrations and photographs.。It is a general book that explains the basic structure and function of the brain in an easy-to-understand manner with CG, illustrations and photographs.。

2/24 (Thur)、The 148th Brain Club was held、The 148th Brain Club was held。About the active role of glial cells in controlling brain function、About the active role of glial cells in controlling brain function、About the active role of glial cells in controlling brain function。How glial cells and nerve cells support (follow?) Each other、How glial cells and nerve cells support (follow?) Each other。

How glial cells and nerve cells support (follow?) Each other、How glial cells and nerve cells support (follow?) Each other、How glial cells and nerve cells support (follow?) Each other、With the students of Yuzuzaki Lab、How glial cells and nerve cells support (follow?) Each other

With the students of Yuzuzaki Lab。

The 147th Brain Club was held!、1The 147th Brain Club was held!。Technologies that enable efficient and quantitative analysis of continuous-section electron microscopic images、He gave a lecture on the interesting role of endoplasmic reticulum-mitochondria in nerve cells.。3D reconstruction using CLEM (video that is assembled on the xyz axis is cool)、One of the analyzes I would like to try in the future (press conference)。

One of the analyzes I would like to try in the future (press conference)

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Fromthe President of the Japan Neuroscience SocietyGreetings at the beginning of the year2022。Let's all do our best this year, too!

12/8/2021, we held our 146th Brain Club and(welcomed Dr. Shigeki Watanabe of the Department of Cell Biology, Johns Hopkins University School of Medicine as the speaker。His talk was titled "Mechanisms of Synaptic Transmission."、He talked about the latest endocytosis mechanism at the presynaptic mechanism using the quick freezing method.。This time, the online seminar was held over 2 days, across the time difference of 14 hours.。(The snapshot after the personal interviews the day after the seminar)。

Dr. Takeo's review "Purkinje Cell Dendrites: The Time-Tested Icon in Histologyhas been published in the book "Cerebellum as a CNS hub" from Springer.。This review summarizes the results of the research on、dendrite development in neurons and its molecular mechanism to the date, Purkinje cells as a model、including Dr. Takeo's own work.。

The 145th Brain Club was held with Dr. Kenichi Oki, Graduate School of Medicine, The University of Tokyo, Department of Integrated Physiology.。Titled "Mouse Vision / Monkey Vision"、Using the latest large-scale Ca imaging technology and tracing technology、He talked about the differences in visual information processing pathways from the retina to the higher visual cortex.。Mouse is a mouse、At the same time different from non-human primates in many ways、I learned the common points as the calculation principle.。This time as well, it was a hybrid seminar at Zoom at the same time as the face-to-face meeting.。

Assistant Professor Tetsuya Takano was selected as a third-year member in the JST PRESTO "Cell Interactions in Multicellular Systems and Their Dynamics" area (Yoshiko Takahashi Research Supervisor).。Congratulations!

The 144th Brain Club Seminar, which had been postponed for a year and a half from February 2020 due to the influence of COVID-19, was held.。The talk was titled "human-specific program that controls the development and evolution of the cerebral cortex" by Professor Ikuo Suzuki of the Graduate School of Science, the University of Tokyo.。

In addition to face-to-face lectures given in ample space and under infection-protection settings、it was a hybrid event with real-time streaming via Zoom.。
Both face-to-face and Zoom sessions were lively with questions and answers、We all enjoyed the Brain Club after a long absence。(We took off our masks only when taking this picture. We held our breaths, then。）

Assistant Professor Tetsuya Takano won、2021Annual Award of the Japan Neuroscience Society Encouragement Award!Congratulations!!。The award-winning achievements、will be published as a review in Neuroscience Research。It was also adopted for the cover photo。

As a member of our research team、We are looking for another person who can promote research together.。You need to be familiar with basic molecular biology techniques,、We will also teach you what you need here。Those who have experience in mouse breeding and management、as well as those who are interested in public relations are even more welcome。

Employment with research grants。Treatment is in accordance with Keio University regulations。Complete with various insurance。It is also possible to use a recreation center, etc.。

・ Resume (with photo) (Please describe so that you can understand the skills and knowledge you have acquired so far。) Free format
・ If there is a reference, please provide name and contact information (e-mail address)。

We hold an interview after the document screening.、Applications will be closed as soon as the suitable candidate is found。
Please e-mail with the application documents attached、to our laboratory secretary, Ms. Akiyo Hirayama (hirayama@keio.jp) with cc to Ms. Kaori Yoshikawa( kyoshikawa.a3@keio.jp).。

The work of Dr. Matsuda (Associate Professor, University of Electro-Communications, Visiting Associate Professor, Keio Physiology)has been accepted by J Biol Chem.。Congratulations!。

Long-term repression phenomenon (LTD), which is considered to be the basic course of memory and learning)Is the number of AMPA receptors in the postsynaptic、It is believed that its molecular level entity is reduced due to internalization (endocytosis) by neural activity.。By phosphorylating the intracellular domain, which is conventionally different for each subunit of AMPA receptor、It was thought that the endocytosis of the AMPA receptor itself was regulated。On the other hand、Phosphorylation of TARP that binds to AMPA receptor regardless of AMPA receptor subunit、From binding AP-2, which is essential for endocytosis, to the AMPA-TARP complex、It was a mystery how AMPA receptor subunits could control LTD.。In this paper、The phosphorylation status of the GluA1 subunit of the AMPA receptor、Discovered to change the strength of the bond between TARP and AP-2。Although TARP cannot distinguish the subunits of AMPA receptors、AP-2 can distinguish the phosphorylation state of each subunit of AMPA-TARP receptor.。

Lecturer Ishida will be promoted as a team leader of RIKEN CBS on July 1st.。She will be leading the Laboratory for Brain Development and Disorders、and their goal is to connect molecules and circuits to untangle developmental disorders、.。Congratulations! (Dr. Ishida is the very first graduate student of Yuzuzaki Lab at Keio.)。

Even in everyday life、Even in nature world、When making something new、Oftentimes, you must break the old one before that。When the morphology of nerve cells changes in our brain according to the developmental stage and memory / learning、Cooperately、It is always accompanied by the destruction of nerve cells and the extracellular matrix around them.。As one of the mechanisms responsible for such a scrap and build phenomenon、The secretion of lysosomes from nerve cells is raising attention。Although lysosomes are usually known as the final digestion site for aging intracellular products,、,、We have found that, In response to hyperactivity, it releases the synapse-forming molecule Cbln1 with the lysosome enzyme, which is the content of the lysosome (Neuron 2019).。In this review paper、we overviewed lysosome secretion in the nervous system。Dr. Ibata, who has transferred to St. Marianna University, is the first author.。

We are、looking for a few researchers (technicians) who can assist our research as a member of our team with a sense of responsibility and cooperation.。It is necessary that you are familiar with basic molecular biology technology, fluent in speaking Japanese, hopefully, in reading as well.、We will also teach you what you need here。Those who have experience in mouse breeding and management、as well as those who are interested in public relations are even more welcome。

[Job title / term]
Researchers (technicians)：Employment with Grants-in-Aid for Research。
Depending on your achievements and experience、there may be a certain trial period。

[Starting time]
Respond to consultation。

【Work location】
Shinanomachi, Shinjuku-ku, Tokyo 35 Keio University School of Medicine, Integrated Medical Science Research Building

【treatment】
Follows Keio University regulations。Complete with various insurance。It is also possible to use a recreation center, etc.。

[Items to be submitted](Free format)
・ Resume (with photo) (Please state the skills and knowledge you have acquired so far, as well as Japanese language proficiency.。）
・ If there is a reference, please provide name and contact information (e-mail address)。

[Application deadline]
We hold an interview after the document screening.、Applications will be closed as soon as the suitable candidate is found。
Thus, there is no specific deadline.、If you are interested, please e-mail us first.。

【To apply】
Please e-mail with the application documents attached、to our laboratory secretary, Ms. Akiyo Hirayama (hirayama@keio.jp) with cc to Ms. Kaori Yoshikawa( kyoshikawa.a3@keio.jp).。

Keio University School of Medicine HP "Features"takes up the research of our laboratory。

Department of Neurophysiology, Keio University School of Medicine、has participated in World Brain Week activities 、named "The Recommendation of Brain Studies" 、for high school students who are interested in neuroscience and university research、Not just to know the excitement of brain science,、We hope this event will be an opportunity for you to learn some of the cutting edge of our research at Keio.。
This year、Although access to the university is restricted due to the COVID-19、we are preparing online lectures and virtual lab tours、as well as various projects such as live distribution.。We are looking forward to your participation 。

[Details]Keio University World Brain Week website
https://sites.google.com/view/keioneuroscience
World Brain Week Keio 2020 Poster_A4

Assistant Professor Takeo's paper”GluD2- and Cbln1-mediated competitive interactions shape the dendritic arbors of cerebellar Purkinje cells”,was published in Neuron.。It was her work while studying abroad at Dr. Liqun Luo Lab at Stanford University.。Congratulations!。

Professor Yuzaki was featured in the digital edition of Asahi Shimbun, in the series of、Keio University and Asahi Shimbun joint project "This piece of research and life".。
It ’s a familiar cell for us、but it's beautiful。Assistant Professor Takeo took this artistic photo。

Rett syndrome is caused by a deletion or decrease in the amount of a nuclear protein called MeCP2 that binds to methylated DNA.、Highly associated with autism spectrum disorders。On the other hand、It is known that even if the amount of MeCP2 protein is increased, mental developmental disorders occur.。However、Until now, it was not well understood how the amount of MeCP2 causes mental illness.。In this study, the amount of MeCP2 regulates the three-dimensional structure of chromatin in nerve cells.、The possibility of changing the expression of various genes was clearly shown using a mouse model.。This work is based on the research conducted by Lecturer Ishida at Zogbhi Lab while studying abroad.、After returning to Japan, it wasPublished in J Neurosci.。

We start reading "Principles of neurobiology 2nd edition"。

Dr. Liqun Luo, a leading figure in the field of neuroscience、wrote this book based on her 20-year's of teaching neurobiology class at Stanford University.。2020The second edition was published in September as a revised edition for the first time in five years.。If you are interested in neurobiology、or English、join our reading circle。

Please e-mail us to attend。10First meeting wil be held at 18:00 on Thursday, 15th of March、.。

※ For further information、please contact Mari*.。

[Place] Held online

[Target] Anyone who wants to learn neurophysiology、or English、and who is interested in reading circle。Individuals of any backgrounds and ages are welcome。

Department of Neurophysiology, Keio University School of Medicine (Yuzaki Lab)  .

*Mari Shiozaki：mari.z6@keio.jp

Formed for the first time in TaiwanTaiwan Society for Neuroscience（TSfN)Tournament is between September 11th and 13th、Held as a hybrid of real conference and web conference。Yuzuzaki as Plenary Talk、「How to Build Synapses: New Mechanisms by Extracellular Scaffolding ProteinsI gave a lecture on。After playing a pre-recorded video lecture at the venue、A lively question-and-answer session was held by connecting Japan and Taiwan online in real time.。

Held from August 31st to September 2nd as a real and web hybrid tournament in Okayama61st Annual Meeting of the Japanese Neurological SocietyIn、"Basic-Clinical" at the Japan Neurological Society (clinical society of neurology) and the Japan Neuroscience Society / Japan Neurochemistry Association、Cross-society symposium：Let's turn our attention to basic science for the treatment of future diseases "。Yuzuzaki says "Recommendation of basic researchI gave a lecture entitled "。

Synapses, which are places for information transmission between nerve cells, are formed by proteins called synapse organizers.、Responsible for precise control of memory and movement。In this study、Based on the structure of synapse organizer proteins、we designed an artificial synapse organizer、and have developed an artificial synapse connector CPTX that can connect excitatory synapses in a wide range of the nervous system.。.、.、When CPTX is administered to the causative region of disease model mice caused by synaptic disruption such as Alzheimer's disease, or spinal cord injury、Reduced synapses recover within a few days、Found to significantly improve the condition。This research was the first successful achievement in the design of artificial synaptic connectors and their application to diseases.。Depending on the design of the artificial synapse connector, it is possible to control various types of neural circuits.、It is expected to lead to basic research and future therapeutic applications for psychiatric and neurological disorders.。For the summary,Click here. 。
This is an international joint research between Japan, the UK and Germany.、Dr. Hiroyuki Sasakura of Aichi Medical University、Professor Tsunesei Takeuchi、Dr. Elegheert, MRC Institute for Molecular Biology, UK、Professor Aricescu、Dr. Song of the German Center for Neurodegenerative Diseases、It is the result of the research with Professor Dityatev and his group.。Also、Assistant Professor Suzuki Kondo、Lecturer Keiko Matsuda、Associate Professor Wataru Kakegawa、Researcher Eriko Miura、Assistant Professor Shintaro Otsuka、 Former medical student Tatsuya Shimada、and many other researchers of our lab have contributed to this work。
For Press releaseClick here. 。

The illustrations were drawn byMr. Mizutani Michi.。

"Dynamic control of brain function by scrap and build" The 5th group meeting was held on the Web for the first time from August 17th to 19th.。This year, Yuzuzaki Lab was in charge of the group meeting.。The team of、Assistant Professors Ishikawa,、Yamazaki,、and Suyama,、with Secretaries Hirayama and Yoshikawa, worked together in preparation for the very first online group meeting and finished successfully.。

8A public panel discussion "Brain Science and Society in 2050" was held on the 2nd of March using Zoom webinar.。It is a future plan, outreach, industry-academia collaboration promotion committee collaboration project of the Japanese Society of Neuroscience.。It was also delivered to YouTube at the same time。Lecturer Ishida participated as a panelist from the laboratory。

The 43rd Japan Neuroscience Congress (Chairman Kitazawa)、It was held from July 29th to August 1st as the first web event in response to the corona disaster.。From the laboratory, Yuzuzaki will be the speaker of the special lecture and symposium (control of brain function and formation of pathological conditions by creative destruction).、Keiko Matsuda as a speaker at the Japan-China Neuroscience Society Joint Symposium、Ishida is a symposium organizer and performer (learning from pathological models)：(Cross-cutting approach to understanding developmental disabilities)。

Nagoya University (Faculty of Medicine on February 19)、20Faculty of Science on the dayAt)、Yuzu Saki gave a lecture。Title is "In the beginning there synapse - synaptic modification mechanism as the foundation of psychiatric and neurological disorders" was。

Based on the agreement of AMED and MRC3rd UK-Japan Neuroscience Symposium is EdinburghAt February 3, 2009 - it was held in 5 days。Ishida from the classroom gave a oral presentation announcement。Yuzusaki took part as organizer。In the forward path、Located in CambridgeMRC Lab of Molecular Biology (LMB is the birth place of modern molecular biology where many fundamental discoveries, such as double helix structure of DNA, muscle contraction mechanisms and viral capsid stuctures, are made.)A visit、It gave a joint research meeting。

143rd Brain Club is Yasushi Okada teacher (RIKEN cell polarity govern research team、The University of Tokyo Graduate School of Science、We welcome the University of Tokyo Graduate School of Medicine)。Presentations was "axonal transport of molecular mechanism to explore in the super-resolution, single-molecule imaging"。After the meetingAGITO in Yotsuya 3-chomeI had a fun discussion。

So could not year-end party of yuzu Saki Research in convenience last year、This year made a New Year's party at the lab。There was also a quiz planning using Kahoot at the initiative of the conference-kun。PhotoClick here. 。

Welcomed the Shimogori Tomomi teacher of RIKEN CBS brain development molecular mechanism research team made a second 142 times Brain Club。演題は「Activity dependent protein dynamics for selective dendrite morphogenesis in developing neuron」でした。After the meeting, I moved to KagurazakaCampañolaI had a fun discussion。

We are looking for cage cleaning staff of research for the mouse。

* Beginners welcome、This guidance carefully *

Job Description： Cleaning of the cage of research for the mouse
Between the time： 10：00～17：004-5 hour or so between
Month - 2 days to 3 days about a week out of gold
(month,Fire + 1 day, but the hope、Day Time Negotiable)
The period： First month 1 month subscription、After that year the unit contract ※ up to 5 years
When to: 1100Yen (1050 yen college student)
Be encountered： Transportation expenses specified in the payment

* Those who are breeding the rodents from hamster or the like in your home, please refrain from。

Application method：Resume (photo attached) to a contact and work possible Date、On the specified time、, Please mail
Email Application Allowed。If you get your submissions by Email、Please call first to the following。

Phone: 03-5363-3749

As for high school students who are interested in research、Not just to know the excitement of brain science,、As the opportunity to touch the one end of the forefront of research、New outreach planning a "soot of brain study" was conducted on November 2 (Saturday)。Keio University School of Medicine, Physiology I, II, Pharmacology, This 4-classroom joint planning of the electron microscope chamber。Although it has no time beyond the recruitment number of people (20 people)、Under the weather、On the day of high school students who gathered from all over the country took part eagerly。This project as one of the world's brain week (Brain Awareness Week) event、NPO corporation "Century Promotion Conference of the brain."I received a sponsorship。

Hiroshi Kawabe teacher (Kobe Medical Industry Development Promotion Organization、Welcomed the Kobe University Graduate School of Medicine) gave the 141st Brain Club。Title is the "spine formation by ubiquitination and synaptic plasticity of the control mechanism."。

About 30,000 of neuroscientists gather from around the world Society for Neuroscience in (Society for Neuroscience)、It has been passed away in December of last yearSymposium to commemorate the late Masao Ito Professor”Dissecting Cerebellar Function: A Prototypical Circuit Critical for Motor Learning and Cognition”The was organize。
M. Kano (IRCN, Univ Tokyo, Japan), M. R. Carey (Champalimaud Center For the Unknown, Lisboa, Portugal), M. Yuzaki (Keio Univ, Japan), C. J. Stoodley (American Univ, Washington D.C.)4 people were announced of。It was a symposium to once again feel the greatness of Ito teacher。

Yet even "10 anniversary, but I do not even 25 anniversary、The meeting "to celebrate boost the yuzu Yamazaki laboratory was conducted by the Meiji Memorial Hall on October 14。1995From the next 1996 years it was appointed in December、St of America Memphis, Tennessee. Yuzu 﨑研 at 3 staff in total at Jude Children's Research Hospital has raised the cry。The subsequent 2003 up to the present through the Heinin the current, Keio University School of Medicine、We have a meeting of the celebration along with the person who I am engaged in research and education together。People who came long road、Those who did not come the day、And thank you deeply for those who have to prepare for the celebration meeting。Now also come in a large ship、I want to do my best to be able to be reached at all far more distant。Thank you very much。

Gave a 140th Brain Club welcomed the Yasuda Ryohei teacher。演題は「Postsynaptic biochemical computation underlying synaptic, circuit and behavioral plasticity」です。After the seminar of KagurazakaSaketokotobukiFun moments in the Nico Chealsea。

Yuzu Saki took part in Talk and panel discussion at the Mitsubishi Foundation 50th Anniversary Symposium。We hear also the story of the famous RIKEN Yoshinori Tokura teacher at a high temperature superconductivity and the like at the symposium。We embrace the gratitude and again pay tribute to the Mitsubishi Foundation, which has gotten a wide range of support to the humanities and social welfare business, not only the natural sciences。PhotoClick here. 。

Retreat was held in Doshisha University Brain ScienceAt yuzu Saki gave a special lecture。Presentations was "beginning to synaptic Ariki functional and morphological synaptic modification mechanism."。

In Japan and the United States brain information exchange seminar (Current Trends and Future Directions of Synapse-Circuit Plasticity Research) Yuzusaki is narrated、Nozawa and conference of graduate students gave a poster presentation。Murayama Tadashimube teacher of the Japanese side RIKEN in Gotemba plateau this year、The United States side of Duke University of Scott Soderling teacher was organizing。3Close discussions and exchanges over the day and a half have been made。

139th of Brain Club was done by inviting YuSono Misa teacher from the University of Bordeaux。演題はLive STED microscopy reveals structural basis of astrocytic Ca2+ signals at tripartite synapsesです。

Yuzusaki is the United Kingdom on June 27, Kings’ It was held at College LondonUK-DRI synapse SymposiumIt gave the invited talk at。

Welcome than Fekrije Selimi teacher CNRS and made a second 137 times Brain Club。The title was "Molecular control of synapse identity and plasticity in cerebellar Purkinje cells" (Picture taken at the time of the laboratory visit after the seminar)。

Yuzusaki June 9, 2006 - was held in Southern New Hampshire University in 14 daysGordon conference "Excitatory Synapses and Brain Function"It gave a inivted talk at。

Yuzusaki is on June 7Harvard Medical School (neuroscience program)I gave a seminar at。The host is Umemori eaves teacher。

We update announcements of reading circle meeting。The first time Ryowa first year, June 21 (Friday) 18：00We plan to。For details please SchedulePlease refer to。

Suzuki assistant、Lecturer Keiko Matsuda、And Yuzusaki is、On May 27, respectivelySymposium was held at the University of Bordeaux Neurocampus "Molecular Mechanisms of Glutamate Receptor SignalingIt gave the invited talks at "。

University of Lyon Yuzusaki seminar at (Université Claude Bernard Lyon 1)The we。Jean-Louis Bessereau professor was the host。

Yuzusaki were carried out at in France of Roscoff on May 20-24 daysJacques Monod ConferenceIt gave a (ligand-gated ion channels from atomic structure to synaptic transmission) in the invited talk。Suzuki from lab Assistant Professor、Keiko Matsuda lecturer also participated had s Mai performs each poster presentation。

Ibata's paper、In Neuron magazine May 6, online version (US Eastern time 11:00).。Protein Cbln1 which has a function to create a new synapses、That is secreted from the lysosomes of nerve cells in response to neuronal activity、This study, which was revealed by the experiments using a mouse。
Lysosomes is、A cell organelles with enzymes that break down proteins、It plays a decomposition of no longer needed intracellular protein。Cbln1 was found to be present in the lysosome in the axons of nerve cells by this time of the study。Also, when the neural activity is enhanced、The contents of the lysosomes from axons that (a proteolytic enzyme and Cbln1) are both secreted out of the cells was found for the first time。From these experimental results、Destruction and synapse formation by Cbln1 extracellular environment by proteolytic enzymes、By working in concert、Possibility that the restructuring takes place in the synapse in response to neural activity is suggested。Synaptic reorganization is an entity of memory and learning、The failure have been reported in a number of mental illnesses and neurodevelopmental disorder、The results of this research are expected to lead to the development of understanding and new treatments for the normal development mechanism and these conditions。
Press releaseHere

Suzuki KuniMichisuke Christian papers of (Adjunct)Frontiers in Neurosci誌.。As part of its international activities support business Young Glia of the new academic area (glial assembly) is the result of joint research with Alexander Ditytatev Institute of Germany DZNE。Suzuki-kun is co-first author。Congratulations!。

135th Brain Club was held titled "dementia and the prion-like propagation" to welcome the Naruhito Hasegawa teacher (Tokyo Medical Research Institute, dementia, higher brain function research field)。

Brain Bee (Brain Science Olympics)Japan representative candidate 4 people came to visit the laboratory。1After the time of the lecture、I was eager to learn to slow down the training, such as an electrical recording by the patch-clamp technique in the prism adaptation and brain sections。

Brain Bee is in the event that the NPO "the century of the brain" is performed in order to foster the next generation to learn the brain science、Japan Neuroscience Society and JapanBrain Science Society of AssociationThere has sponsored。northeast·Shikoku medium andKyushu, Kanto, the four people who won the district of qualifying Kansai Japan representative candidates will head to the world tournament after this。Also7Japan Neuroscience Society of the monthAlso done award ceremony at。

134th Brain Club is Matthew P. Mr. Anderson (Harvard Medical School)Welcomed Shi、It was held titled "Mapping the Circuits that Control Aggression via Autism Gene Convergence"。

133rd Brain Club is Shi welcomed Haruhiko Shiomi teacher (Keio University School of Medicine molecular biology classroom)、It was held titled "De novo DNA methylation and chromatin architecture during mouse gonocyte" (methylation and chromatin structure of DNA in the mouse Gore Roh site)。

Kono-san's doctoral paper、which was published in the Journal of Physiology, was featured in Perspective.。According to the comment, ”These results by Kono et al. (2019) represent a major step forward to cut the Gordian knot regarding the precise subcellular localization of NMDARs in the cerebellar microcircuitry and the cellular mechanism of PF–CF signal integration”.、They also describe that this paper represents a major step to fully understand where and how NMDA receptors function in the cerebellar circuit。The expression "cut the Gordian knot"、means "put an end to a long-standing question in an unexpected way."。Since it was tied by Gordius King、nobody was able to untie it (the Gordian knot)、when the Alexander the Great cut the knot by the sword。

Kaichi as part of the "quest activities" of high school、1Grade of Omino Mr.、3 people's Seino has been come to yuzu Saki Research。After a brief lecture、It gave a enthusiastic question and answer session with the laboratory tour。I hope you went interested in neuroscience even a little to the people of the next generation。

Hokkaido University of Education University Hakodate junior high school sophomore Maeda Mr.、Igarashi-kun、Machiya-kun of 3 people、It came to yuzu Saki Research as part of the graduation study。After a brief lecture、It gave a enthusiastic question and answer session with the laboratory tour。I hope you go interested in the future even a little neuroscience。

The UK Medical Research Council (MRC: Based Medical Research Council) and the MOC (memorandum of understanding on cooperation) of Japan medical research and development mechanism (AMED)、Following the open day English neuroscience symposium last year in London、The second meeting was held in the dates of February 9-11 days in Chiba Prefecture Kisarazu of Kazusa Academia Hall。Yuzusaki has participated as an organizer from AMED side。

132nd Brain Club has been done to welcome the Atsushi Yamagata teacher (University of Tokyo quantitative Institute of Life Sciences tip quantitative life science research departments) entitled "infrastructure of control by selective splicing and complex formation of synaptic organizer" It was。

Yuzusaki isSeminar at Nagoya University Research Institute of Environmental Medicine,It gave a (Medicine Advanced Course)。”Getting started of new synapses (and break the way)How to Construct and Deconstruct Synapses”It is titled。We had a good time to interact with many of the young researchers, including the mountains (Akihiro) Research and Ken Osakada。

131st Brain Club was to welcome the Iino Masamitsu teacher (Nihon University School of Medicine) carried out under the heading of "physiological and pathological conditions of the central nervous system to explore with calcium imaging"。

75th Fujiwara Symposium (The Cerebellum as a CNS Hub) is、12From one day a month of 4 days、It was held at the Tokyo Medical and Dental University。Mizusawa Professor、Ken Professor as organizer、Timothy from abroad Ebner, Michael Hausser, Germund Hesslow, Hong Jiang, Sheng-Han Kuo, Phil Hyu Lee, Stephen Lisberger, Mario Manto, Javier Medina, Chris Miall, Christopher Person, Stefan Plust, Jennifer Raymond, Jeremy Schmahmann, Reza Shadmehr, John Simpson, Peter Strickland, Catherine Stoodley, Bing-Wen Soong, Peter Their, Dagmar Timmann, Jan Voogt, Chris De Zeeuw、It is an international symposium that led to the cerebellum researchers 30 people coming further from Japan。Is the father of the cerebellum study of the 90 th birthday of Masao Ito teacher celebration was also serves as。PhotoHere →

Ishida lecturer has been adopted in the pharmaceutical Foundation research expenses Kanae。

It gave a celebration meeting of Gakushin DC graduate of conference-kun and Nozawa-kun。Congrats!

J Physiology (London)PhD 4 years of the magazineKono's thesisIt came out。
It is well known that the expression of LTP and LTD, which is considered as the basis for processes of memory NMDA receptor (NMDA receptor) is essential。In the previous study、In the important cerebellum to the motor learning、NMDA receptor had been shown to be required for the expression of LTD and LTP。But almost no NMDA receptor expression in the cerebellar Purkinje cells after mature。 paper、NMDA receptors expressed together which cells、How do you control the LTP / LTD? In this paper、Purkinje cells、Granulosa cells、We were challenged with this problem by deficient NMDA receptor gene in each intervening neurons。

Muscle fibers are created by the fusion of myoblasts。Fusion of myoblasts happened even during muscle regeneration after damage, not only during development、It has been strictly controlled。We've discovered as a molecule to control the strengthening and pruning of climbing fibers of the cerebellum so far BAI3 is、Although the muscle fibers to be involved in the fusion of myoblasts had been shown so far、The detailed molecular mechanism was not well understood。In this paper、C1qL4 suppresses the BAI3、Stabilin-2 has revealed that temporally and spatially controlled fusion of myoblasts by activating (→ paper is here.）。Synapse formation is C1qL1-BAI3 in the cerebellum、In the muscle it is extremely interesting that C1qL4-BAI3 to control the muscle formation。As a joint research with Canada's Jean-François Côté laboratory、Conference and Kakegawa, Associate Professor of short-term come the Viviane Tran's a graduate student was indebted to Keio。

River Iwasaki Hiroshi teacher(Kanazawa University of Medicine, Neurosurgery, School of Medicine,)The 130 times Brain Club due to have been made。The title is "analysis of the cerebral cortex formation mechanism using the mouse and ferret"。

On this occasion、For the development of JST ERATO Keio University bases ( "neuro molecular techniques", Kyoto University Hamachi Summary - 2018- 2024) (representative, Kakegawa)、We are looking for new Fellow in the (engineer)。

In this ERATO study、By the creation of chemical biology molecular techniques、The changes in the synapses associated with neuronal activity and memory and learning、And elucidation at the individual protein molecule level。As a result、Changes in the synapses in normal and psychiatric and neurological disorders pathology elucidated at the molecular level、We aim that will lead to new treatment and diagnostic technology。Close collaboration will be required of the Kyoto base for this purpose (bio-organic chemistry and supramolecular chemistry) and Keio base (neuroscience)。

As the business of the special researcher、As Keio base of this studyAdministrative and public relationsWith、Research SupportIt will be carried out。
(1) those who want to try to participate in the Keio base as a member of the research team
(2)Those who have a sense of responsibility and cooperative spirit
(3) If there is a research experience and laboratory work experience (desirable but not required)
Please apply all means。

If you are interested, please prepare 1) CV with、2) 2 people Reference destination (name and contact information)、3)Preferred interview date、and contact Lab Secretaries (hirayama@keio.jp, yuri.y@keio.jp) to Please apply。For further questions, please contact them, too.。.、Please note that Application documents should not be returned。Payroll will be determined according to the University rules。The recruitment will be closed as soon as personnel are found。It was closed。

On this occasion、Conference-kun of the graduate students of this laboratory (D3)And Nozawa-kun (D1)Each but、Japan Society for the Promotion of Science Research Fellow (DC)It became a pre - approved in。Congratulations!。

Yuzusaki reblogged Talk in place the Cold Spring Harbor Asia symposium in Awaji Island。Conference (D3)And Nozawa (D1)Each also、I gave a poster presentation。

Development process of the dendrites of nerve cells are not fully reproduced in the in vitro。For example, juvenile type of neurites but will be trimmed once in the in vivo、This behavior does not know the mechanism may not be observed in in vitro。In this study by observing neurite development process in in vivo by performing intrauterine electroporation、It was revealed that Caveolin-1 controls the development process of dendrites via endocytosis of N- cadherin and L1。It is the job of when the Sendai's has been stayed's with Shikanai to yuzu Saki Research。Paper is here →

Activity-dependent endocytosis of AMPA receptors at postsynaptic sites、which underlies long-term depression (LTD), is thought to mediate certain forms of learning and memory in vivo。However、whether LTD at synaptic levels is causally related to learning and memory at system levels has remained unclear。In thisNeuron paper、using a new optogenetic tool, termed PhotonSABER, which could acutely and reversibly inhibit LTD in a light-dependent manner、we show that LTD at parallel fiber-Purkinje cell synapses、is essential for eye movement-based motor learning in vivo。Dr. Kakegawa, Associate Professor at Keio University、and Dr. Matsuda, Associate Professor at the University of Electro-Communications、performed all experiments with great helps from Dr. Kato, Associate Professor (Tokai Univ.), Dr. Fukasawa, Professor (Fukui Univ) and Dr. Kohda, Professor (St. Mali University School of Medicine)。

TheVideo Abstract has been published in Neuron.。YouTube is here.→。

On this occasion、With the expansion of personnel changes and Research、Newly started the recruitment of Assistant Professor (Adjunct) 1 person。Payroll will be determined according to the University rules。

Depending on the changes in the neural activity and the environment、It is selectively enhanced to attenuation particular synapse、Or they are newly formed and removed。This process not only is the basis processes of memory and learning、It has become apparent in recent years is the basis of the change in the connect mix in a variety of psychiatric disorders and developmental disorders。Our laboratory is、Such molecular basis of functional and morphological synaptic plasticity、We aim to elucidate the molecular biology, electrophysiology and behavioral biological。

As the field
１．Electrophysiological(Brain slices and in vivo) orImagingPeople with a strong background in the field
２．Molecular biology, morphologyPeople with a strong background in the field
I assume any of the。Taking advantage of each of the background、Let's by all means greatly developed from Japan synapse research together。Also I think you'll connect to the future of the step up to learn a new technique in the lab。

If you are interested, please prepare 1) CV with、 2) Research proposal、3) wrote two people Reference destination (name and contact information)、Kawasaki grapefruit research(name and contact information)Please apply to。For further questions, please contact them, too.。The recruitment will be closed as soon as personnel are found。It was closed。

Nozawa-kun, a freshman in the PhD course, has published hisvery first paper in "the Cerebellum."。As there are no antibodies that can be used for immunohistochemical staining、cellular and subcellular localization of Neuroligin-1 has been unclear。Nozawa-kun, together with Hayashi-san、generated a mouse line, in which an HA epitope tag was knocked in the neuroligin-1 gene、Using anti-HA antibody, Nozawa-kun has clarified cellular and sucellular localization of endogenous Neuroligin-1 in the cerebellum。

In good offices All of Keio University School of Medicine and biology classroom, Kajimura Professor、This year also from 2:00 July 14, Saturday, to the laboratory, which was intended for first-year medical school tours have been made。In spite prior to the test、Faculty of Science and Technology, two students + medical students 11 people took part in the eagerly lecture and practice。Some from this will expect to grow up to become a species that aspire to medical research in the future。Photos here（Updated on September2PageThere is also a)。

Since Shimada and Mr. Obata's has been participating in the new labLunch meeting of welcomeThe we。Thank you very much。

It gave a farewell party of Otsuka-kun to study in Anis Contractor Institute of Northwestern University。We prayed all the more and more active。Photos here。

We ate the cake with everyone to celebrate the secretary of the day。Thank you very much。Photos here

Per the Center for Molecular Neuroscience launched at Stanford University、4月20日にシンポジウムIt has been made。Yuzusaki is I will call on the Nobel Prize scholar Thomas Sudhof、It gave a Keynote address。The Center for Molecular Neuroscience is in a virtual organization、So far long Then came the "Synapse Club" development to eliminate the、We aim to understand the neural circuits and normal and abnormal brain function by understanding the workings of at the molecular level of the synapse。Stanford University School of Medicine、Neuroscience researcher of nearby universities such as UCSF and UCSD not only neurobiology faculty had gathered。Of this timeOther Speaker,,ja,はKang Sheng,,zh-CN,Christian Rosenmund,,en,Lu Chen,,zh-CN,Julia Lalitsschmidt,,en,Li Gan,,zh-CN,He is Dr. Sue Ackerman.,,jaはKang Sheng, Christian Rosenmund, Lu Chen, Julia Lalitsschmidt, Li Gan, Sue Ackerman is Dr.。

留学にあたり竹尾さんの送別会（Photos here)The we。Stanford University Liqun is Luo Research。I wish you a fulfilling student life。

本年度の脳科学オリンピック（Brain Bee)I gave a lecture at the yuzu Saki Research practice (the prism adaptation and patch clamp confocal nerve cell observation · Rotorod test under a microscope) to the candidates 5 people。In contact with very sharp questions to come to the students of the high 1-high 3、Japan of brain science research was also thought that bright。Okumura teacher、Thank you very much discount rate。

Dr. Kei Cho (United Kingdom Dementia Research Institute at King’s College London) gave a talk entitled “Synapse weakening mechanism: Potential therapeutic intervention for Alzheimer’s disease” at the 126th Brain Club. Here’s other photos.

OISTにて3月14－15日の2日間行われたMini Symposium: Synapses and Circuits - Yuzusaki by the Development and Function gave a Talk。Speaker wa Xiaoqin Wang (John Hopkins), Dan Sanes (NYU), Yoko Yazaki-Sugiyama (OIST), Daniela Vallentin (Freie Universitat), Keiko Tanaka-Yamamoto (KIST), Wen-Biao Gan (Skirball, NYU), Hisashi Umemori (Harvard), Michisuke Yuzaki (Keio), Peter Scheiffele (Biozentrum), Yimin Zou (UCSD)was。We enjoyed a free and lively Scientific Discussion。

平成30年3月5日-6日にUK-Japan Neuroscience SymposiumThere was held at the London of the Royal Society。This symposium、AMED and the MRC (Medical Research Council) is what based on a memorandum of understanding for joint research that signed。University of Japanese-English、research Institute、Research support institutions、About 90 people from the private sector or the like has been carried out presentations and panel discussion to participate。Yuzusaki the University of Tokyo Iwatsubo teacher、I served as orgnizer of Japan side together with RIKEN Goda teacher。The Yuzusaki Research officials、Mr. Suzuki、And Matsuda-kun of UEC gave the oral presentation。PhotoClick here. 。

Dr. George J. Augustine (Lee Kong Chian School of Medicine, NTU, Singapore) gave a talk entitled “Molecular Mechanisms of Short-term Synaptic Depression” at the 124th Brain Club.

Dr. Samuel Young (Molecular Auditory Research Department of Anatomy and Cell Biology, Department of Otolaryngology, University of Iowa) gave a talk, entitled “Uncovering the molecular mechanisms of presynaptic active zone protein regulation of neurotransmitter release” at the 123rd Brain Club.

Dr. Etsuo A. Susaki,( Lecturer /Senior Research Associate at Dept. of Systems Pharmacology, Grad. Sch. of Med, )It was done by inviting。The title is "CUBIC：Cell is omics pipeline "toward the understanding of the multi-cell system。

Dr. Toshihiro Nomura, It was done by inviting Northwestern University)。タイトルは「Aberrant GABA signaling in the developing sensory cortex in fragile X syndrome」でした。In addition to photosClick here. 。

A new review on Synaptic Organizers “Two Classes of Secreted Synaptic Organizers in the Central Nervous System”  has been published in Annual Review of Physiology. 

Dr. Kosei Takeuchi　(Professor at Dept. Biology, Aichi Medical University))It was done by inviting。The title was "nerve damage due to sugar chain expression control and spinal cord injury repair and expansion aimed at drug discovery."。

A Farewell party for Dr. Keiji Ibata was held atラ・タペリアIt was conducted in。I hope more and more of your success in Xintiandi (St. Marianna University School of Medicine)。PhotoClick here. 。

Dr. Kenzo Hirose9(Professor at Dept. Neurobiology, (the University of Tokyo)It was done by inviting。The title is, "glutamate imaging and pre-synaptic mechanism that has become apparent in the super-resolution microscopy"。

Dr. Yuzaki was invited as a Special Lecturer at the 2017 Society of Neuroscience held in Washington DC (Nov. 11-15th)(movie1)(movie2)The we。

Dr. Weilun Sun, supported by the Young Glia grant, came from Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) and stayed in our lab to perform experiments with Kuni Suzuki. We all enjoyed his visit.

医学部1年I gave a training and lecture as a laboratory tour on the raw。Thank you very much Kajimura teacher of the discount rate。

The Japanese translated version of "Principles of Neurobiology (by Liqun Luo)," a text book we use at Dr. reading club”, has just been ”published.There has been published。Translation supervisor is by the Tokyo University of Okabe Professor and Yuzusaki。Undergraduate students who want Ya learn deeply the neuroscience、Very good for graduate students、Is a textbook of up-to-date。Even teachers of our department born I was involved in the translation。

第118回Brain Clubを山田 朋子 先生(筑波大学 医学医療系 助教)We invited。The title was "epigenetics in the differentiation and function of the cerebellum"。

第117回Brain Club SeminarをYale大学の山崎世和先It was conducted by raw。Title was "Identification of new auxiliary subunits that controls the inhibitory synaptic transmission and GABAA receptor complex formation"。

Dr. Scott Soderling (Depts of Cell Biology and Neurobiology ,Duke University ), gave a talk entitled “Neural Circuit Selective Analysis of Behaviors Relevant to Psychiatric Disorders” at the 116th Brain Club.

Dr. Stoyan Stoyanov, supported by the Young Glia grant, came from Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) and stayed in our lab to perform experiments with Kuni Suzuki. We all enjoyed his visit. Please see,en other photos.

With the expansion of this time research、Newly, who has strongIt began recruiting。Payroll will be determined according to the University rules。

Depending on the changes in the neural activity and the environment、It is selectively enhanced to attenuation particular synapse、Or they are newly formed and removed。This process not only is the basis processes of memory and learning、It has become apparent in recent years is the basis of the change in the connect mix in a variety of psychiatric disorders and developmental disorders。Our laboratory is、Such molecular basis of functional and morphological synaptic plasticity、We aim to elucidate the molecular biology, electrophysiology and behavioral biological。

sendthe following items toin vivo or Ms. Y. Tomizuka (yuri.y@keio.jp) :In particular, it assumes people with a。While taking advantage of these background、New technologies (molecular biology and genetic engineering) learned by those who aim at the future of the step-up of、I'd love to、１）CV、 2) Research proposal、3) 2 people Reference destination (name and contact information)write、Kawasaki grapefruit research(name and contact information)Please apply to。For further questions, please contact them, too.。The recruitment will be closed as soon as personnel are found。It was closed。Thank you very much many of your submissions。

Excitatory neurotransmitter in our brain are borne by glutamate、Especially AMPA receptor is an important receptor that convey the fast neurotransmission。It is what the number of AMPA receptors in the postsynaptic changes in the long term、It is thought that the most fundamental processes of memory。So far about a change in the number of AMPA receptors、Or carried out by antibody staining in fixed specimens、Or it has been studied by expressing the exogenous AMPA receptor with a fluorescent probe。In this research、By developing an entirely new chemical labeling method、Endogenous AMPA receptors in the brain were visualized、We were able to observed over time the change。This achievement is the result of joint research by Kyoto University Ken Hamachi and yuzu 﨑研 that have been made with the support of the JST CREST。It was published in Nature Communication.。

Dr. Anis Contractor (Department of Physiology, FSM and Department of Neurobiology, WCAS Northwestern University) gave a talk at the 115th Brain Club on April 6th.  The title of the talk was “Life without Kainate Receptors: Insights from Kainate Receptor Knockout Mice.”

Dr. Jaewon Ko (Laboratory of Neural Circuits and Social Behaviours Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST), Korea) gave a talk at the 114th Brain Club on March 23rd. The title of the talk was “Molecular Principles of Neural Circuit Development: Synapse Organizers.”

It was published in "Japanese researchers who have appeared in the journal Science," the annual。From and this project is started is the appearance of the second time following in 2011。This booklet is誰でもダウンロードして読めますのでどうぞ。Thesis of Yuzusakiken is 44 pages。

The First group meeting of the new academic area, "dynamic control of brain function by scrap-and-build process" was carried out in March 6 to 8 days Karuizawa Prince Hotel。Diligently until late at night I stayed the Discussion was made to the lodge。

Axon's first clause (AIS) is a site that generates an action potential、Formed by Ankyrin G has been known to be controlled。But Ankyrin or G is given to how the integration was not well understood。Papers this time microtubule bridging molecules MTCL1 revealed that plays an essential role in the formation and maintenance of AIS isThis work has been published in EMBO J.it was done。Is the study of the Satake-san and Suzuki, professor of Yokohama City University。Yuzu In Nagasaki Institute is a joint research san and Miura Takeo has the help of intrauterine electroporation and organizations analysis。

In the new academic area "nerve Glycobiology" final symposium Suzuki Assistant Professor (Adjunct) was awarded the Best Poster Award。Congrats!

A new review on C1q family proteins “The C1q complement family of synaptic organizers: not just complementary.” has been published in Current Opinion in Neurobiology.

By introducing mRNA encoding the transcription factor、How to efficiently and rapidly differentiated from iPS cells into motor neuronsScientific Reportsにpublishit was done。This paper is the result of joint research with Hong teacher of the system Medicine。Also it was featured in such Nihon Keizai Shimbun。

 A reunion party of Keio Physiology Laboratories was held on February 11, 2017. A lecture was also given by Dr. Shibata,ja. See photo.

On February 3 and 6, Dr. Radu Aricescu, a visiting professor from Oxford University, gave two lectures on entitled “Introduction to Modern Structural Biology.”

A review on the delta glutamate receptors (wheels) “A GluD Coming-Of-Age Story (A GluD Coming-of-Age Story)” has been published in Trends in Neuroscience.

Dr. Yuzaki participated and gave a talk at the NUS-Keio Joint Symposium at the National University of Singapore on January 10-11th, 2017. See photos.

Symposium held at the "brain circuit creation of Elucidation and control technology of the formation and operation principle of the forefront 2017- brain circuit of research" is January 20 (Friday) 10:00 30 minutes to Conference Square M (Marunouchi Mitsubishi building 10F) willTodid。This symposium by eight research team that has been adopted in AMED-CREST research expenses。People Ya, which is engaged in the life science and medical research、Planning is that target to the general public who are interested in the mechanism of the brain。Alone with participation tightening is up to 13 days。Click here for detailsUntil。

Otsuka-kun’s thesis paper has been published in J Neurosci. This work was done in collaboration with Dr. Konno (co-first author) in Prof. Watanabe’s laboratory and Dr. Abe in Prof. Sakimura’s laboratory. It was featured as “It has been featured in "This Week in The Journal." .”

 Dr. Yuzaki gave a talk at The 47th NIPS International Symposium “Decoding Synapses,” held at the National Institute of Physiological Science on October 26-28, 2016.

Prof. Yuzaki gave a talk at the OIST mini-symposium/the Core-to-Core program of JSPS, entitled “Nanoscale mechanisms of synaptic functions,” which was held on September 25- 27 at Okinawa. Other speakers include: Larry Trussell, Robert Edwards, Volker Hauck, Nils Brose, If Kavalalı, Ian Forsythe, Peter Jonas, Stephan Sigrist, Reinhard Jahn,Ryuichi Shigemoto, Stephan Hallermann, Alan Marty, Tobias Moser, Ko Matsui, Hiroaki Misonou, Haruhiko Bito, Shinya Kawaguchi, Toshihisa Otsuka, Sumiko Mochida and Tomoyuki Takahashi.

A review for general readers"Science in Keio University School of Medicine"A review of Keiko Matsuda lecturer was published in the。

A new group grantIn the "dynamic control of brain function due to scrap and build" Kakenhi new academic area studies、As kick-off symposium and public research briefing the following will be heldYou。、It ended on a high note。
Date and time：2016On September 8 (wood) 13:00-17:00
Meeting place：The University of Tokyo Faculty of Science, Building No. 1 Koshiba Hall
http://www.u-tokyo.ac.jp/campusmap/cam01_00_25_j.html

For more details, until the Grants-in-Aid for Scientific Research Scientific Research on Innovative Areas "dynamic control of by the scrap-and-build brain function."。
http://www.scrapandbuild.bs.s.u-tokyo.ac.jp/

A new paper, based on collaboration with Dr. Arisesuku's lab at Oxford University, 7has been published in Science on July 15th..。In this research、It is a joint of nerve cells and nerve cells to reveal the structure of the bridge that connects the "synapse"、Nerve cells in conjunction with each other was to elucidate the new mechanisms regulating neural network function。The results of this research”It was featured in the "This week in Science“But it was introduced as "Transmitting signals across the synapse (signal beyond the synapse)."。

In the synapse、Glutamate is released from presynaptic、Excitement to the next nerve cell is transmitted by binding to the glutamate receptor of postsynaptic。Furthermore, from presynaptic、It has been revealed in our laboratory that the group of molecules similar to "complement" of the immune system be released to adjust the synaptic function so far。However、And excitement transmission path through the glutamic acid、How to work and how synaptic regulatory pathways by complement family molecules did not know well。

In small brain circuit、Presynaptic releases complement family molecules referred to as CB El N. 1 (Cbln1)、And then binds to a receptor that neurexins (Nrx) present in the presynaptic。On the other hand、Cbln1 will cause the synapse formed by combining at the same time also to the postsynaptic delta type 2 glutamate receptor (GluD2)。Nozawa-kun, together with Hayashi-san、Nrx-Cbln1-GluD2 the structure of the three-party complex that was the first time Tokiakasa。as a result、Cbln1 not only serve to anchor the presynaptic and postsynaptic as adhesive、By adjusting the working styles itself postsynaptic GluD2 the subtle、It was found to control the happened ease of excitement transmission in the synapse (= memory and learning process)。

Complement family molecules · Nrx · glutamate receptors are also present in various brain regions other than the cerebellum。Therefore、This was revealed、Functional regulation mechanism of glutamate receptors by complement family molecules are expected to be working as well in a variety of neural circuits。

Glutamate receptors conformation of the ligand binding site will change by the binding of glutamate。It introduced two His residues to the appropriate site of the ligand binding site、By varying the conformation by Pd molecules administration、Methods of modulating artificially activated, inactivation of ionotropic and metabotropic glutamate receptors has been developed。In this study of the Qing in Kubota teacher of Ken Kyoto University Hamachi your job、6A month 28 daysAOP in Nature Chemistry magazineIt was published as。Yuzusakiken has participated as CREST sharing research。

In this laboratory、With the expansion of the promotion and research of predecessor、Newly started the recruitment of assistant professors 1-2 people。In response to this until the experience、Depending on the qualification, we considereitherIt expects to。Payroll will be determined according to the University rules。

Depending on the changes in the neural activity and the environment、It is selectively enhanced to attenuation particular synapse、Or they are newly formed and removed。This process not only is the basis processes of memory and learning、It has become apparent in recent years is the basis of the change in the connect mix in a variety of psychiatric disorders and developmental disorders。Our laboratory is、Such molecular basis of functional and morphological synaptic plasticity、We aim to elucidate the molecular biology, electrophysiology and behavioral biological。

There is interest in these areas、If it is aimed at the future of the step-up、I'd love to、１）CV、 2) Research proposal、3) Two references (name and contact information)Writing、Kawasaki grapefruit research(name and contact information)Please apply to。For further questions, please contact them, too.。The recruitment will be closed as soon as personnel are found。It was closed。Thank you for a lot of applicants。

Keiko Matsuda lecturer and Tim Budisantoso kun is first author of the paper4Online version of Neuron of the month 28 days.。

Kainate receptors of the glutamate receptor、There was particularly high in specific synapses of the hippocampus, an important brain region in memory and learning、The transmission rate that is slow not to other receptors、And the essential role in the integration of hippocampal neural network activity。However、Whether incorporated only to certain synaptic kainate receptors what mechanism、The mechanism was not well understood。In this paper, the、By neurons secrete proteins called the C1ql2 and C1ql3、I found that coming to collect the kainate receptors directly。Also、In the hippocampus of mice lacking the C1ql2 and C1ql3、Kainate receptors is not incorporated into the synapse、Be less likely to occur epileptic seizures was found be given a stimulus to induce epileptic artificially。

C1ql2、C1ql3 is also present in various brain regions、Are considered each by controlling the built-in and function of kainate receptor synaptic neural make up the appropriate neural network activity。The results of this research、It is expected to be of use in the therapy method development and cause elucidation of epilepsy and autism。

This paper、As this month's attention paper of Neuron magazinePreview “Synaptic Menage a Trois”Was introduced as (ThreesomesPlease check out our own meaning of。）

Koda, Associate Prof. promotion as St. Marianna University School of Medicine Department of Physiology professor from April 1。1996St. Jude (but was back in the temporary Tokyo University psychiatry in the middle) Children's Research yuzu Saki Institute at the hospital since joined as the first post-doc at the time of the birth is the beginnings of the oldest founding life member in year。I wish more and more of your success future。

4It belated celebration meeting a month 15 days (farewell party) at the Art Complex。As Koda teacher himself Violin player、Miura (Violin)、Nozawa Jun (Viola)、Great string quartet by Takeo's (Cello) have been made。Photos here→

Papers about the synapse control by the Notch of Takeo Assistant Professor (Adjunct)Scientific Reports.。It is what the work in Tomita Research finally settled。Congratulations!。

Dr. Christophe Mulle (CNRS, University of Bordeaux, Bordeaux, France) gave a talk entitled “Synaptic dysfunction in a memory circuit in models of Alzheimer’s disease” at the 108th Brain Club on March 28th.

This year two teams from yuzu Saki Institute as the first attemptTamagawa Riverside EkidenI participated in。Cbln1 a team and C1qL1 team。Cheers for good work Did!

3month15It gave a farewell Mukaekai of 2016 on the day。This time, the welcome of Nozawa-kun of graduate students (MSc) and conference-kun (PhD)、It is Narumi-kun of the pick-up that who have supported for many years laboratory。Narumi-kun of the favorite food (such as fried) was conducted in the lab a wide variety。Photos here。

ToshibaOnline magazine "has Wereki"Interview article for the general public of Yuzusaki was published in the。

Prof. Ryohei Yasuda (Scientific Director, Max Planck Florida Institute for Neuroscience) gave a talk entitled “Illuminating signal transduction in single dendritic spines” at the 107th Brain Club.

A review of Kakegawa, Mazda Yuzusaki "Complement C1q family molecules and the formation and maintenance of synapses" isAnnual Review神経2016.。

Prof. Takao Hensch (Children’s Hosp, Harvard Univ) gave a talk entitled “Balancing plasticity/stability across brain development” at the 106th Brain Club.

Kakegawa lecturer was awarded the Koyo Sakaguchi Memorial Keio University Medical Science Fund Medical Research Award。1 It was honored at the annual School of Medicine, New Year celebration ceremony held to 5 days a month。Congratulations!

We will soon start a new series of Neuroscience Book Reading Club.
We have picked up "Principles of Neurobiology" this time. This book was written by a single author,. Liqun Luo is all text of the written neurobiology alone。If you want to study neurobiology、or English、and who is interested in reading circle、Anyone、By all means we are welcome to join。

A meeting will be held on every Saturday morning 10:00Although we plan to - about 1 hour、Please contact us for more information。Dates can be also be changed by discussion of participants。Tour is also a big welcome。

A new review has been published in the Japanese journal "Igakuno Ayumi," entitled"How Purkinje cell dendrites are formed -- a new approach to the old question revealed multipe roles played by a transcripton factor RORα."I was laid。

Prof. Nils Brose (Max Planck Institute) gave an invited talk on “Neuroligins at inhibitory synapses – from synaptogenesis to autism spectrum disorders.” After the seminar, we had fun time in a local Japanese restaurant.

Prof. Yuzaki gave an invited talk at Northwestern Univ on October 16th.

Prof. Yuzaki gave an invited talk at the 7th MCCS-Asia Meeting, which was held in Shanghai, China on September 20, 2015.

“Dr. Douglas Forrest (NIH) gave an invited talk at the 104th Brain Club on “Transcriptional and hormonal control of photoreceptor diversity.

Dr. Takeo's paperThere was rests on the September 9 issue J Neurosci。It has been featured in "This Week in The Journal." It was featured as one of the attention paper two as。By making full use of the intrauterine electroporation method and inducible knockdown / knockout method、Cell movement of the transfer factor RORalpha developmental period、Removing dendrites formed、Spinous process development、This paper was the first time revealed that further with the dendrites and the spinous process maintenance, such as various functions of the post-mature。

38th Annual Meeting of the Japan Neuroscience Society, which was held on July 28-31, 2015 in Kobe has ended successfully。Many of the people who had you help、Also everyone who actively join us、Thank you very much。Is a commemorative photo taken during the session。From left Okabe program chair (University of Tokyo)、Yuzusaki tournament length (Keio Univ.), Hirai Executive Committee (Gundai)、Koda's execution vice chairman (Keio Univ.)。

（Updated on September9, 2015Please visit the web page showingmany snap photosPlease see that it has been。

Our work has been featured in the “Keio Research Highlights.”

Professor Yuzaki. In invitation of Giovanna Mallucci、Yuzusaki the Univ on July 6. It gave a Invited Seminar at Cambridge。Lecture Theatre subjected to Talk is located in Clifford Allbutt Building、2013Laboratory of Molecular Biology until year (LMB is the birth place of modern molecular biology where many fundamental discoveries, such as double helix structure of DNA, muscle contraction mechanisms and viral capsid stuctures, are made.)Of there was just (now moved to a new building)。LMB the DNA double helix、Muscle contraction、Is one the birthplace of molecular biology, such as the discovery of the structure of the virus has been made。10Toka things Nobel Prize has come out。

Prof. Yuzaki has joined the Editorial Board of the Journal of Physiology (JP)I went into the Editorial Board。Editorial Board meeting was held in London of Hudgkin Huxley House on July 4。Hodgkin in the past in the physiology of the prestigious magazine JP was could the Iwasu, Huxley, Katz, Starling, Sherrington, It has produced a Nobel Prize in Physiology or Medicine winners of Hill et al.。The state of the social gathering after the meetingClick here. 。

A review paper entitledPaper introduce "C1ql1：A new molecule "to control the form and function of the brain synapsesIt was resting。

A review paper entitled "Side with the strong and crush the weak: a new synapse organizer C1ql1""Frustrate the weak help the mighty" - new C1ql1 signaling responsible for pruning synapses "I was laid。

A farewell party forWe of the farewell party at the Osteria Quattro Valli。It will be promotion to Kobe as Advanced Medical Center Research Institute Senior Fellow。

Dr. Peter Scheiffele gave a talk at the 100th memorable Brain Club seminar.

A party was held in the lab to welcome Drs. Arai, Kohno, Tomizuka and Hayashi with assorted Sushi and sparkling wines.

Dr. Malenka gave a talk at the 97th Brain Club Seminar.

A farewell party for Tim-kun and Kurauchi-sanThe was conducted at Osteria Quattro Valli。

18th Aisemusu International Symposium：15th International cell membrane Research ForumThere Yuzusaki is done in four days from March 2, it gave a invited talk。

As "the forefront of brain circuit Research 2015"、Towards the general targeted as a 2nd CREST symposium on February 21, 2015.There was held on February 21 (Saturday)。Yuzusaki gave a continued announced in the first times。

Prof. Yuzaki was invited to the panel discussion held at RIKEN BSI to talk about the theme: "High Impact Science vs. High Impact Journals". . Yuzusaki in a panel discussion on the theme at RIKEN BSI called High Impact Journals took part。When I thought at ease because it was referred to the person of the meeting of postdoctoral、That the rest of the panelists Susumu Tonegawa Sensei and Shun-ichi Amari teacher、I was very surprised。

A Japanese review entitled "How single winner climbing fiber is selected and maintained by C1ql1 signaling in the cerebellum"There was published。

A new paper on a synaptogenic role of C1ql1, a C1q family member, has been published in Neuron..。It was also selected to the Featured Article。A press release from the JST isClick here. 。Press release at Keio University isClick here. 。Science portalClick here. 。

A book entitled "Brain Extracellular Matrix in Health and Disease""It has been published。Chapter 2 Neural ECM and Synaptogenesis Yuzusaki has shared writing。

Matsuda lecturer reblogged promotion as the University of Electro-Communications, Associate Professor as of November 1,。On October 29 being missed in all of labIn October 29th, a send-off party was held at Alice Garden , The we。I wish more and more of your success future。

4th ECMnet meeting was held in Turkey (Antalya)。Planning a co-sponsored session with the new academic area from Japan、Yuzu Kawasaki and Suzuki from Keio、Kadomatsu teacher from Nagoya University、Kitagawa teacher from Kobe Pharmaceutical University has made an oral presentation。

We had a great time at the Japan Neuroscience Society (JNS) in Yokohama, with Ryouhei Yasuda（Max Planck Florida), )、Beth Stevens（Harvard Univ）、Wataru Kakegawa (Keio)、Yukari Takeo (Keio)、Suzuki Kunimichi (Keio)、Sachiko Tsuda (Saitama Univ.)、Yuzusaki sent a good time in seven (Keio)。

We have organized a symposium, entitled "Old but new synaptic organizers: diverse but common mechanisms" in the 9th FENS Forum of Neuroscience in MIlan, Italy with Drs. Radu Aricescu (Oxford Univ, UK), Michi Yuzaki (Keio Univ, Japan), Cagla Eroglu (Duke Univ, USA), Yuki Goda (RIKEN BSI, Japan). : diverse but common mechanisms "and was organize。After the symposium at the shop of Sardina cuisine (Nochola Allen will have a Photo smartphone of Radu)。

In 3 to 4 July in Rome6th International cerebellum Society SymposiumI gave an invited talk at。

Delta type 1 glutamate receptor (GluD1) is、Delta receptor type 2 with (GluD2)、Not know function while belong to the glutamate receptor family、It has been treated as an orphan receptor。The GluD1 protein has been considered also a little present in the mature brain。However、Abnormalities GluD1 gene in human mental disorders are reported one after another in recent years、It can be seen that the phenotype, such as aggression increased and social deterioration even in GluD1 gene-deficient mice can be seen、Function of GluD1 has been attracting attention。On this occasion、By developing GluD1 specific antibody、Specifically GluD1 was the first time that the expression evident in various brain regions such as the brain, the limbic system, striatum, cerebellum also in the mature brain。In particular by GluD1 genetic defects in the cerebellum、Synapses between parallel fibers (granule cell axons) intervening neurons were found to decrease significantly。
These results have been published in theJournal of NeurosciencePublished in、It has been featured in "This Week in The Journal." It was featured in。It is the result of joint research with Niigata cerebral Research, Sakimura Institute with a focus on Hokkaido University School of Medicine Ken Watanabe。

IST AustriaInInivited talkThe we。Prof. It was the invitation of Shigemoto。

A job opening for a research technician。
1) that you have mastered the basic techniques, such as molecular biology and cell culture。
2) that there is that dealing with the mouse。
We will assist the management of auxiliary and laboratory General of other researchers。Also actively support however possible to carry out research has its own theme in consultation。Through the work of our laboratory、I want to aim their careers up with to contribute to the forefront of neuroscience research、We are looking for people who are ambitious and sense of responsibility that。

This recruitment has been closed。 Thank you very much for your application。

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Was the cherry blossoms in Yotsuya。

Now、The Yuzusaki as PI、Oxford Radu Aricescu 大学 博士、International joint research with Alexander Dityatev Dr. Germany neurodegenerative disease Institute (DZNE) "Bridge over troubled synapses: synthetic extracellular protein scaffolds for neuronal connectivity" has been awarded2014as the Research Grant by the Human Frontier Science Program (HFSP)It was adopted as。841Only 24 items, except the items young frame 10 from the matter of the application was the tough competition that has been adopted。3Continue year。

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Natori's farewell and Ebine's、It gave a welcome party of Iwamoto Mr.。

In the 3rd volume of "Integrated Reviews in Life Sciences 2014,"World of delta：Story Delta receptors of certain orphan receptor: has been published"I was published。

This time Kakegawa lecturer was awarded the Irisawa Memorial Young Award。Congrats!!Is the award that aims to encourage young researchers of Japan Physiological Society, which is doing a creative, exploratory basic research in the area related to the heart and circulation and ion channels, transporters。

Suzuki Kunimichi Mr.、Yukari Takeo、Tim Budisantoso kun was elected Fellow of the Society for the Promotion of Science (PD and foreign researchers)。Congrats!

One of the formation and function of the excitatory synaptic and inhibitory synaptic input to the nerve cells is believed to have been controlled in conjunction with each other, but we do not know well the entity。Cerebellar parallel fibers and secretion in this paper、Is Cbln1 to strongly promote the formation of a functional excitatory synapses between Purkinje cell - parallel fibers、It has revealed that to suppress the formation and function of inhibitory synapses intervening neural over Purkinje intercellular。This studyEuropean Journal of Neuroscience.。Ishida's graduate student OB's work centered on the (currently studying in the United States)。

Was held Keio Medical Science Society meeting, new academic area · Brain Club mini-symposium co-sponsored the "Neuronal function and dysfunction mediated by protein glycosylation" on January 8,。Michael D of US Pfizer neuroscience department. Dr. Ehlers、Shi invited Alexander Dityatev Dr. Magdeburg University / Germany neurodegenerative disease center、Lively debate took place。

January 2014 issue of Comprehensive Rehabilitation ( Vol.42 No.1)"Synaptic plasticity as the foundation process of nerve function recovery" review of the Koda-Yuzusaki to - "Current Topics featured advances in brain science" was published in the。

Long-term depression is one of synaptic plasticity (LTD; Long-Term Depression）は、By the number of AMPA receptors in dendrites decreases、Efficiency of information transfer in the synapse is the phenomenon to be reduced in the long term。But we do not know well whether the number of AMPA receptors is controlled by any mechanism。Elucidation of the mechanism is not only a better understanding of brain function、It is expected to lead to the development of the understanding and treatment of a variety of brain diseases。

It will be transported to the cell membrane (cell surface) after present in the cell membrane "membrane protein" that is synthesized in the cell。Membrane protein receives information extracellular、It plays a function of transmitting to the cell。For example AMPA receptors will excite the nerve cells by binding to the glutamate。The amount of membrane protein present on the cell surface、Transport and from within the cell to the cell membrane、It has been precisely controlled by a balance of speed to take from the cell membrane into the cell。This latter process is generally controlled by AP-2 or AP-3A adapter protein。But whether the transport into the cell of the AMPA receptor is controlled how by the adapter protein was a mystery until this。

Matsuda Shinnanji lecturer、In this paper, a protein that binds tightly to the AMPA receptor Stargazin is、We found that it binds strongly when it is dephosphorylated with the enhancement of neural activity in the AP-2 and AP-3A。as a result、AMPA receptor -Stargazin complexes efficiently incorporate into cells、The number of AMPA receptors on the cell surface over a long period of time is reduced。Through this research、So far of the AMPA receptor that is directly linked to memory and learning was a mystery intracellular transport mechanism is now revealed for the first time。Nature CommunicationsIt became the online published in。

Wataru Kakegawa lecturer was awarded a pharmaceutical Foundation research grants Kanae 42nd。10Presentation ceremony was held in the month 30 days。

Symposium was held October 21 to 25 at the Cold Spring Harbor Asia Conferences "Development, Function and Disease of Neural CircuitsYuzu Saki gave an invited talk at "。Furthermore, he gave a lecture at a mini-symposium at Zhejiang University on October 26。

Reports of 2 family of people lacking the 2 receptor deltaNeurologyMagazine.。We mutation of previously mousewould-15JIn exactly the same exon 2 as that report has been deleted。It is characterized by proceeding to the cerebellar atrophy progressive Unlike the mouse in humans。Delta 2 receptor gene locus is known as a very mutation-prone sites、Also families lacking the delta 2 receptor is considered to find what the future。This study is a joint research with Harvard University Ganesh Mochida teacher and Hokkaido University Watanabe laboratory。

I was held on the 11th September 2013 at Yurakucho Asahi HallCentury Symposium of 21st brainAt yuzu Saki gave a general lecture。The day will continue in your opening remarks of the teacher Kanazawa、A special lecture is done than Masao Ito teacher、Continue Osaka University Masatoshi Takeda teacher、Keio University Yuzusaki、Osaka University Tanaka teacher、It is performed lecture in the order of the RIKEN BSI Kuroda teacher、It became the closing by the greetings of Tadaharu teacher。

Was carried out between 13 to 11 September at Pacifico Yokohama86th Conference of the Japanese Biochemical SocietyIn、At the symposium "New Development of the recycling system research in which the cells have"、Matsuda (Shin) lecturer has announced。The Sendai lecturer new aspects of the symposium "membrane traffic：It hosted the control "of the physiological function in cooperation with a variety of cellular events announced。

I was done at 06, 05 September 2013 at the British Embassy"Challenge to neuroscience, disease using next-generation optical microscope" MRC-JST joint workshopYuzusaki to participate in、It gave a discussion about the possibility of future bilateral joint research。

August 31, 2013 at the Nagoya Congress Center as Strategic Research Program for Brain Sciences, comprehensive brain joint planningSymposium entitled "- - for the health of the heart and brain over a lifetime lifestyle brain"Yuzu Saki gave with Okazawa teacher of Tokyo Medical and Dental moderated facilitators of。On the day of RIKEN BSI Shimogori teacher from brain professional challenges E、National Center of Neurology and Psychiatry KUNUGI the teacher、In addition to the Tokyo Medical and Dental Mizusawa teacher、Yamaguchi University psychiatry Watanabe teacher、Following the lecture from Kyoto University Imura teacher、Lively general discussion about strategies for maintaining the "health of the brain and mind over a lifetime" was carried out。

2013Yuzusaki at Gordon conference was held at the United States New Hampshire State New London from August 11 days a year to 16 days (cerebellum) gave the invited talk。Hot discussion about the cerebellum have been made from a wide variety, such as generation and nerve circuits and synaptic plasticity ... motion learning and pathology point of view。

× 21 (July 2013 numbers)「Transport Saum and brain」A review of Kakegawa, Koda-Yuzusaki "new synaptic plasticity mechanism by'm not -δ2 type glutamate receptors and Cbln1 that just to form a synapse" was published in the。

2013It was held at the Niigata University Brain Science Institute on July 26, years43rd Niigata neurology Summer SeminarAt yuzu Saki gave a lecture。

Between July 23 to 25, 2013 in Shiga Prefecture Laforet Biwako、I took part in the new academic area "nerve sugar chain biology" group meeting。Yuzusaki from our laboratory、Matsuda、Otsuka、Suzuki will participate、I made a hot debate。

2013July 18 - The was carried out in the United States Seattle US-Japan Brain Research Collaborative Program was held in 20 days。今回のテーマは“Current Trends and Future Directions of Synaptic Plasticity Research”です。Mr. Suzuki of Assistant Professor in addition to the invited talk of Yuzusaki from our department、Graduate students of Otsuka Mr. gave a poster presentation。

Iijima TakashiToshi Dr. our laboratory born (Assistant Professor → Switzerland while studying) is、2013Of the yearJapanese Neural Chemical Society Award for YoungIt was won。congratulations! Double award in conjunction with Ishida's Neuroscience Society。

2013Gordon meeting held in Switzerland · Les Diablerets from June 9 year up to 14 days Yuzusaki at (excitatory synapses and brain function) gave the invited talk。Control mechanism and structure at the front and rear of excitatory synapses、And hot discussion from a variety of approaches for functional and morphological plasticity and pathology associated with memory and learning have been made。

幸田講師（専任）が准教授に昇進しました　 😀 　また、鈴木邦道くん(TA (Extraordinary))、Timotheus Budisantosoくんが研究室に参加しました。

This laboratory acquired Aya Ishida Dr. degree in (currently the United States during the study) is、2013Of the yearby the Japan Neuroscience SocietyIt was won。Congratulations!

Yuzu Saki than the Ministry of Education, Culture, Sports, Science and Technology、Was awarded the Education, Culture, Sports, Science Minister's Commendation of the 2013 fiscal year the field of science and technology。Photo Kaoru Inokuchi teacher of Toyama, which became a winner at the same time、National Institute for Physiological Sciences of Tadashi Isa teacher groups (Kyoto University, Watanabe large teacher、Fukushima Prefectural Medical University Kazuto Kobayashi teacher)、It is a commemorative photo of the Osaka University, 栁澤 teacher of young science Award。MoreClick here. 。

Exchange of information between nerve cells takes place in the synapse。Long-term suppression of transmission efficiency of synaptic (LTD) is、Is the foundation process of learning and memory in the brain。In the cerebellum、Cerebellar granule cells by learning - LTD in synaptic transmission between Purkinje cells)It plays an essential role in memory to be involved in the movement that occurs (such as dexterity and timing)。LTD In general postsynaptic neurons、Caused by a reduction in the number of AMPA receptor to receive the glutamic acid。Features of cerebellar LTD is、It is to require delta type 2 glutamate receptor specifically present in Purkinje cells in addition to。The cause and mechanism had been left for many years remains a mystery。Finally succeeded in solving this mystery in this paper。Delta 2 receptors by controlling the phosphorylation state of the AMPA receptor、It was found that acts as a so-called master key to determine whether or not occur or LTD occurs。

In this study, Drs. Kohda and Kakegawa showed that the serine phosphorylation of AMPA receptors required prior dephosphorylation of the nearby tyrosine residue. By interaction with a tyrosine phosphatase, δ2 glutamate receptors regulated tyrosine dephosphorylation status of GluA2 to gate inducibility of LTD. These findings will provide better understanding of general mechanisms regulating AMPA receptor endocytosis during synaptic plasticity. This paper has been published in PNAS.。For Press releaseClick here. 。

2012Dr. Ishida's paper, whichappeared in Neuron has beenThere has been introduced in the Preview as paper should be noted in Developmental Cell magazine。

Read the Preview at: Choreographing the axo-dendritic dance. Dev Cell 23:923-924,2012.

Keiko Matsuda's paper, which was published in the European Journal of Neuroscience (EJN) in 2011 hasbeen selected asthe EJN most cited papers in 2011-12He was elected to。

The original articles is here→Matsuda K, Yuzaki M. Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions. Eur J Neurosci 33:1447-1461,2011

A degree in our laboratory、Will continue papers Aya Ishida was Gakushin Fellow of the (SPD) at Ken Okabe Tokyo University, Dr. (now the United States studying abroad)Neuron 志 (2012 年 11 月 号).。It is the result of joint research with the University of Tokyo Ken Okabe Ken Watanabe Hokkaido。

In the central nervous system、I do not know still much about how the synapse is going to be formed。In this study、By over time imaging using living neurons、It was to clarify this issue。The synapses between cerebellar granule cells and Purkinje cells、After postsynaptic structures (spine) of the previously formed、Presynaptic will be formed。Is Cbln1 molecules released from the granule cells、By binding to presynaptic Neurexin and postsynaptic GluD2、To induce the formation of small protrusions from presynaptic、It was found to form synapses front of the structure (the button)。

In this issue は”The Synapse” and. by M. Sheng, B.L. Sabatini and T.C. Sudohof, Cold Spring Harbor Press, 2012Read the。

Form of synaptic、function、plasticity、Over pathology and variety、Is a book by researchers of the first line of each field was written by。As advanced course after reading the textbook of neuroscience、If you are interested、We expect a large number of participants。We do not question the classroom inside and outside, universities inside and outside, job title, etc.。

10Than every Tuesday 18 am as a rule than the moon 30 days will be made in our department。Inquiry (TheKodaUp)

This year's Tokizane Prize has been awarded to Prof. Yuzaki.Tokizane Prize is established with a trust fund donated from Mme. Nobu Tokizane. Prof. Toshihiko Tokizane (1910~1973) was one of the prominent pioneer and ａ great promoter of brain science in Japan.It was won。The grant reward type は 35 back to Japan God 経 Science ConferenceIt was held at。

The 35th Japan at Neuroscience Symposium - gave a "control of neural plasticity by sugar chain towards the fusion of the sugar chain science and neuroscience."。It is co-sponsored by the new academic research "integrated operating principle elucidation of sugar chain that target the control of neurological function."。(Following titles omitted) the Chair is Yuzusaki and Nagoya-kadomatsu done、Miyata as Shinpojisuto Shinro (Kobe Kusuridai-biochemical / Kobe courtyard Medical · GCOE)、Sayaka Sugiyama (Niigata Institute Iha and neurological development)、Geoffrey T Swanson (Dept Mol Pharmacol and Biol Chem, Northwestern Univ), Radu Aricescu (University of Oxford), James Fawcett (University of Cambridge)The celebrated。

The functions of the brain、It was written to the general publicThis book, with a lot of color illustrations,There has been published。It is co-translation of the Uchiyama professor of Juntendo University。(Takeshi Yoro teacher translation supervisor)。Since the illustration has full entered、It is recommended as an introduction。

On July 13th, Prof. Yuzaki gave an invited talk in the meeting on "Brain Extracellular Matrix in Health and Disease (ECMNET)," held as a satellite event of Federation of European Neuroscience Societies (FENS) in Barcelona, Spain.There July 12 in Barcelona, ​​Spain as a satellite event of FENS - was held in 13 days。Yuzusaki has done an invited talk。

On April 26th, 2012, Prof. Yuzaki gave an invited talk in theInternational Graduate School of NeuroscienceYuzu Saki gave an invited talk in。”MOLECULAR MECHANISMS OF SYNAPTIC PROCESSING, Under the theme of FUNCTION AND DYSFUNCTION、This symposium over two days。Graduate students has been organized at the initiative。

On April 25, 2012, Prof. Yuzaki gave an invited talkat the DRA symposium on Receptor Structure and Function Yuzu Saki gave an invited talk in。

Dr. Kakegawa has awarded a Yong Scientist Award on his work on "Research on Glutamate Receptors in Regulation of Learning and Memory"from MEXT. It was won。congratulations。

March at the 24-April 1、Kaneda Associate Professor decided to promotion to the Nippon Medical School Graduate School of Medicine professor as successor of Yasuo Sakuma teacher。congratulations。3Modest in the month 19 daysat the Art ComplexThe we。

Matsuda Shinnanji lecturer、Wataru Kakegawa lecturer of papersNeuron (January issue of 2012).。In the results of the close collaboration with the University of Tsukuba KimuTamotsuken、Unoki kun had come to Keio from KimuTamotsuken (graduate student)、3 people of Mazda Kakegawa lecturer is the first author。

Long-term suppression phenomenon (LTD) has been studied in depth so far as a basis the process of memory and learning。When the activity of nerve cells is increased a certain period of time、The AMPA receptor present on the postsynaptic membrane is incorporated into cells (endocytosis) of、It is believed to be the substance of the LTD。In this study、Endocytosis of the AMPA receptor was elucidated for the first time that it is controlled by the synthesis of lipids in the postsynaptic membrane。

Unoki we are a degree in this paper、He was awarded the "Best Paper Award" at the University of Tsukuba。

Assistant Professor is、In PhDs、1) sugar chain science、Or 2) Neurobiology (electrophysiology to cell biology)、Those with either or both the background of。Has its own theme in consultation will be asked to autonomously carry out research。

Researcher is、1) I have mastered the basic techniques, such as molecular biology and cell culture、かつ２）マウスを扱ったことがあるもの。We will assist the management of auxiliary and laboratory General of other researchers。Also actively support however possible to carry out research has its own theme in consultation。

Through the work of our laboratory、I want to aim their careers up with to contribute to the forefront of neuroscience research、We are looking for people who are ambitious and sense of responsibility that。

→2012年1月に全て募集ポストは埋まりました。応募ありがとうございました。 🙂

University of Oxford in England on October 17, 2011OXION（Ion Channels and Disease Initiative) Yuzu Saki gave an invited talk at the Seminar。

第3回European Synapse MeetingThere was held at the Balaton lake in Hungary。It attracted researchers of the front-line from all over Europe and around the world、Hot Discussion was held for three days stay cliff sprinkled with young researchers。Yuzusaki from Japan、Goda teacher of RIKEN BSI、Kuba teacher of Nagoya University gave an invited talk。

The Kakegawa lecturer ga Heisei 23 annual のThirty-four will Jiang Lai rewardIt was won。

Assistant Prof. Kakegawa's paper"D-Ser binding to GluD2 regulates synaptic plasticity and motor learning- δ2 was published as a receptor signaling "。

The 4th International Symposium by the Society for Research on CerebellumThere took place in Japan (University of Tokyo Sanjo Conference Hall) on September 18,。World and famous from Japan cerebellar researchers was a great success gathered。Yuzusaki is”The ins and outs of GluD2 — Why and how Purkinje cells use the special glutamate receptor”Gave a lecture that。

"D-amino acids in the central nervous system" international symposium at the Tokyo Medical and Dental University MD tower was held on September 10, 2011。Tokyo Medical and Dental University brain Integration Research Center (CBIR) is sponsored by、Participation of Joseph Coyle professor of Harvard University, was also there is great success。Also Yuzusaki”Prof. Yuzaki also gave a talk entitled "The delta receptors as new physioｌogical receptors for D-Serine”I gave a lecture entitled。

A prestigious PRESTO grant from the Japan Science and Technology Agency (JST) has been awarded to Dr. Shinji Matsuda.FY2011 Mazda Shinnanji lecturer as a new research leader was elected in。A study of the theme in the five-year period will begin "cell in the transport and synaptic plasticity of control by the light"。

The new academic field "Glyconeurobiology"has been adopted (http://www.mext.go.jp/a_menu/shinkou/hojyo/1308745.htm）。2011It is scheduled from the year 2015、As a member of the planning group、The control of the integrated nerve function will aim to operating principle elucidation of sugar chain that target。

2011On September 27 (Fire) 14：00～17：00It gave a kick-off meeting at Nagoya University ES Hall。

Osaka Bioscience Institute "new group of molecules -C1q protein to control the synapse formation and functional plasticity and delta receptor" lecture at the monthly seminar of (OBI) and was done by Yuzusaki。

This is a review article by Dr. Yuzaki published in The Special Issue of the Current Opinion in Neurobiology on "Synaptic function and regulation (April issue in 2011)To "、Review of Yuzusaki was published on C1ql1 family of molecules is a new synapse formation and maintenance factor Cbln1 and its related protein。Thing that summarizes the work so far of the laboratory。

From Kyoto Hirokawa Shoten、"Transport Zoom of the world - from the headwaters of the membrane transport studies to the future" was out。Is a book that covers the history of the study of channel transporter and its related molecules until recently topic。Yuzusaki has shared writing to the section of the ligand-gated channels of Chapter 2 ion channel。For details please Click here. 。

RIKEN Brain Science Institute (RIKEN-BSI)BSI-Seminar Series is the flagship seminar (BSS)Yuzu Saki gave a lecture at。6Month 9 days - we were given the opportunity to interact with researchers in many of BSI over the two days of the 10 days。

Matsuda (Keiko) and Yuzusaki was featured in the "Japanese researchers placed on the science."。

In the link below you can read the digital edition (article of Yuzusakiken is 28 pages)。

From “Japanese Scientists in Science 2010.” Reprinted with permission from AAAS.“

Keiko Matsuda's paper There are published in the European Journal of Neuroscience、In this issue Featured Article. It was chosen to。Sudhof Dr. told me to write a comment article。



It is a follow-up report of a strong synapse formation and maintenance molecule Cbln1 in the cerebellum, which we have already reported。Although last year's Science paper (2010), the postsynaptic receptors has reported that it is a GluD2、In this paper presynaptic side of the receptor Neurexin (Nrx)It is、In addition brain regions (hippocampus and cerebral cortex) other than the cerebellum any similar molecule (Cbln2 and GluD1)It reported that has a similar synapse formation action。Nrx is known as the gene responsible for autism、But as its receptor, such as Neuroligin and LRRTM it has been known、Nrx-Cbln1-GluD2 is、It is possible to control the synapse formation was found by an independent molecular mechanisms and these molecules。

Baby girl of the second child was born in Kakegawa Assistant Professor。It is 撫菜 (shepherd's purse) chan。Congrats!!

A paper by Kakegawa has been published in Nature Neuroscience (online edition 04 April).。Is a joint research with Kyushu University of Hamase Associate Prof.。

There are many different types of memory、Memory associated with motor skills such as a human of sports and playing a musical instrument activities、Cerebellum of neural circuits are involved。However、Unknown Many points about the molecular mechanisms that control the storage in the cerebellum synapse、For example, we do not know well why to reduced motor learning ability with age。

So far、By protein Cbln1 secreted by neurons in studies using mouse binds to the delta type 2 glutamate receptor (delta 2 receptor)、I had discovered that to control the synapse formation in the cerebellum。Nozawa-kun, together with Hayashi-san、By amino acid D- serine abundant in the cerebellum of juvenile mice bind to delta 2 receptor、To promote the movement memory and learning in the synapse、It was revealed in experiments。In fact D- where serine was prepared and analyzed a genetically modified mouse which can not bind to the delta 2 receptor、Movement memory and learning ability in juvenile life had been significantly reduced。

Binding model of the D- serine and delta 2 receptor、Also believed to be fitted to the people。This finding is、Thing to provide a useful knowledge in understanding the movement memory and learning process in the early childhood of people。Also、Delta 2 receptor is expressed throughout life、By controlling the D- serine pathway、future、There is a possibility that can efficiently to promote motor learning in adults。

Picked up in Yomiuri Shimbun、Nikkan Kogyo Shimbun、It was featured in such as Asahi newspaper children。

JST Press ReleaseHere。

The paper by Emi as the first authorhas been accepted by Neurochem ResNow and in press in。

This thesis has developed a new rapid blink conditioning protocol for the cerebellar motor learning function measurement。But it is scheduled to come out let me know after、The time being Congratulations。

Iijima-kun (now Univ Basel studying in Scheiffele Research) and Miura's co-authored papers have been published in the European Journal of Neuroscience magazine。
http://www3.interscience.wiley.com/journal/123389540/abstract

We used to go the expression and biochemical analysis of C1ql family molecules in the brain。C1q family molecules having a structure similar to that of Cbln1 is specifically expressed in a completely different brain regions and Cbln1、It was found to be secreted as multimeric。Possibility of C1ql family molecules also involved in synaptic function in these brain regions are suggested。

Assistant Professor Matsuda's paperScience Notes (April 16 号).。Hokkaido University of Ken Watanabe、It is a joint research with Ken Shigemoto of NIPS。

Cbln1 receptor delta 2 receptors on the postsynaptic (GluD2)It is、Cbln1-CluD2 complex was discovered for the first time that you have to control the maturation of presynaptic and postsynaptic to the bidirectional。

This paperScience STKEIt was selected as Editor's Choice in。Also it was featured in newspapers and Nikkei Sangyo newspaper Kyodo News system。JST's press releaseClick here. 。

Autophagy is a graduate student journal articles Kun Katsumata(IF:5.48)Now Accept to。This paper referred to as "auto-phagocytosis transchromosomic in nerve axons is retrograde transport to the activity-dependent by dynein"。It is a joint research with Mizushima teacher of Tokyo Medical and Dental University。
http://www.landesbioscience.com/journals/autophagy/article/11262/

Accumulation of swelling and autophagosomal of nerve cell axons have been known in a variety of neurodegenerative diseases and ischemic brain。But not little is known about the physiological significance and the dynamics of the auto phagocytosis transchromosomic in axon。Using live imaging techniques in this paper、Autophagosomes transchromosomic is being transported to the cell body by dynein motor from axon、The number of auto-phagocytosis transchromosomic in axon by glutamate stimulation was revealed for the first time that the increase。

Autophagy is a graduate student journal articles Kun Katsumata(IF:5.48)Now Accept to。This paper referred to as "auto-phagocytosis transchromosomic in nerve axons is retrograde transport to the activity-dependent by dynein"。It is a joint research with Mizushima teacher of Tokyo Medical and Dental University。
http://www.landesbioscience.com/journals/autophagy/article/11262/

Accumulation of swelling and autophagosomal of nerve cell axons have been known in a variety of neurodegenerative diseases and ischemic brain。But not little is known about the physiological significance and the dynamics of the auto phagocytosis transchromosomic in axon。Using live imaging techniques in this paper、Autophagosomes transchromosomic is being transported to the cell body by dynein motor from axon、The number of auto-phagocytosis transchromosomic in axon by glutamate stimulation was revealed for the first time that the increase。

Coverage of the classroom took a "half-science half Professor" column of the Keio University School in the magazine "School"。
http://www.keio.ac.jp/ja/contents/seminar/2010/265_2.html

Thesis of Nishiyama Assistant Professor is now Accept the Journal of Neuroscience。Re-evaluation of neurodegeneration in "error char mouse：Sustained ion influx is not the cell death by autophagy、Is the paper that cause cell death accompanied by autophagy "。It is a joint research with Mizushima teacher of Tokyo Medical and Dental University。
http://www.jneurosci.org/cgi/content/abstract/30/6/2177

A phenomenon that neuronal cell death caused by glutamate receptors hyperexcitability、It has been known as the "excitable cell death"。Error char mouse、The point mutations δ2 type glutamate receptor、Cerebellar Purkinje cells by modifying be a mutant mice that cause cerebellar ataxia、It has been used as a model of excitable cells death for a long time。In the error char mouse、Or cells to die by hyperactivity of the "autophagy" the Purkinje cells engulf yourself、Or die by other causes was a long time unknown。In this paper、Autophagy is a phenomenon to be associated with cell death、It was revealed for the first time that it is not the cause。

Strategic Creative Research Promotion Department in FY 2009 the citrus fruit (CREST)Research area in：It was selected as the new adoption research leader in the "creation of elucidation and control technology of the formation and operation principle of the brain circuit."。

Under the theme of "Elucidation and control of synapse formation mechanism in the mature brain."、Hokkaido University Watanabe laboratory、Efforts will for five years along with the Niigata Sakimura Kenji laboratory。For details please
http://www.jst.go.jp/pr/info/info670/index.html



A paper by Kakegawa has been published in Journal of NeuroscienceIt became Accept to。Under the title "top N-terminal region of δ2 receptors rapidly induce cerebellar parallel fiber synapses in in vivo"、It is a joint research with Miyazaki Watanabe teacher of Hokkaido University。「It has been featured in "This Week in The Journal." "As was featured in this week's attention paper。

The last paper (J. Neurosci. 28:1460-1468, 2008)so、Delta 2 receptors controls the LTD signal transduction system via intracellular domain (C-terminal)、From that had been proposed to control the morphological synapse formation via a separate extracellular domain (N-terminal)。We found that it is actually induced synapse formation delta 2 receptor in just one day after when expressed in the cerebellum of the mature animal using a viral vector in this paper。We also see that the N-terminal domain is necessary and sufficient for this action。

Assistant Professor Iijima's paperJournal of NeuroscienceIt became Accept to。"Cbln1 is expressed suppressed by neural activity - homeostatic control in the development stage and mature stage" is the title of。

We、We previously reported that the new secreted factor Cbln1 is essential to maintain and synapse formation between cerebellar granule cells and Purkinje cells。In this paper、When neural activity in granule cells continuously increased to Cbln1 expression is decreased、As a result, we found that the synapse is out。With such a mechanism、Or maintaining the homeostasis prevent over-excitement、Possibility of motor learning related to that and go synaptic modification is suggested。

Invited review of Yuzusaki became in press in the cerebellum special issue of Neuroscience magazine。The title of "synaptic morphology and plasticity of the control mechanism by the two new molecules delta 2 receptor and Cbln1- old."。

Paperback review where the citrus fruit "Handbook of Neurochemistry & Now and in press in the Molecular Neurobiology "。It is titled "glutamate receptor -NMDA receptor and delta receptor"。

Matsuda (Megumi) thesis of Assistant Professor Kondo visiting researcher co-author is now Accept the European Journal of Neuroscience。
The Matsuda (Megumi) Assistant Professor and Miura Hokkaido University、Now Accept the joint research also European Journal of Neuroscience of the Watanabe teacher。

In the two papers is a new secretory synapse formation factor Cbln1 is、It is what was revealed for the first time to specifically bind to the postsynaptic membrane between cerebellar granule cells and Purkinje cells。That specific receptor has clearly indicated the presence at this site。
Despite using a completely different approach、This is where the fun was arrived at a common conclusion。

Graduate students of Ishida was appointed as Society for the Promotion of Science Research Fellow -SPD from the next fiscal year。Congrats!

Thesis of Matsuda Assistant Professor is now Accept the Autophagy magazine。this is、This invited paper as an Addendum to the Neuron paper。

Matsuda Assistant Professor is、He was awarded the 2008 of the Japan Neuroscience Society Award。Congrats!

Graduate student of Ishida's paper is now Accept the Journal of Neuroscience。Congrats。It was featured in the preface of TWIJ page as this week of attention paper。

Although this variety of synapse formation factors have been known to date、Ya what activity was confirmed in the individual brain (in vivo)、There is no little thing that action has been confirmed in the brain after mature。We are the administration of molecules that are secreted by nerve cells that Cbln1 the cerebellum of adult mice、2A new synapses are formed within days、Movement disorders of cerebellar ataxia mouse has discovered that remission。But since the effect is temporary、Cbln1 that there was sustained was found to be necessary for the maintenance of normal synaptic。

Cbln1 and because the family molecules are also expressed in brain regions other than the cerebellum、By elucidating the signaling system through Cbln1、I can better understand the formation and maintenance of synapses in the adult brain、as a result、It will be expected to lead to elucidation of conditions such as movement disorders and memory impairment。

Graduate student relationship God-kun of the paper is now Accept the Keio Journal of Medicine。Congrats。

Cerebellum exercise learning、It is believed to have been borne by long-term suppression phenomenon of cerebellar granule cells over Purkinje cell synaptic transmission (LTD)。Although the LTD we know that there is a need for protein kinase C and delta type 2 glutamate receptor、The detailed molecular mechanism is unknown。It was first demonstrated that not to participate in the LTD to be directly phosphorylated by protein kinase C in a delta receptor itself in this paper。

Kakegawa Assistant Professor was awarded the 2007 Japan Physiological Society Award。Congrats!

Mr. Ishida, a healthy baby girl graduate (3265g; Apgar 9-10-10) was born。It is Chie-chan。Congrats!

Thesis of Matsuda Assistant Professor is now Accept the Neuron。Congrats。

AMPA receptor is responsible for the fast neurotransmitter in our brain、We have to control the memory and learning process。AMPA receptors are usually transported to the postsynaptic (dendrites)、Do not go to the presynaptic (axons)。The mechanism of this "polar transport" It was long a mystery、We、AP-4 of the adapter protein that controls the vesicular transport membrane proteins、Was the first time revealed that responsible for this polarity transport。further、Since AMPA receptors that are erroneously transported to the axon is decomposed captured by autophagosomes transchromosomic internally axon、AP-4 is to be involved in autophagy activity has been suggested。

This work is the result of joint research with Hokkaido University Miura, Watanabe teacher。

Baby girl first child was born in Kakegawa Assistant Professor。It is auction-chan。Congrats!!

Kakegawa Assistant Professor of paper is now Accept the Journal of Neuroscience。

Delta 2 receptors、It is essential for synapse formation in the cerebellum、At the same time synaptic plasticity phenomena underlying course of motor learning (long-term depression：Controls LTD)。In other words、Delta receptor is a unique molecule that controls the functional synaptic plasticity and morphological synaptic plasticity。By our lab work so far、Delta 2 receptors、Although it belongs to ionotropic glutamate receptor family、It does not bind to glutamate、And it has been reported that does not function as an ion channel。

In this study the intracellular site of delta 2 receptors (C-terminal) is、It is essential for functional synaptic plasticity features such as LTD and motor learning (eyeblink conditioning)、On the other hand、The morphological synapse formation was the first time revealed that the C-terminus is not essential。In other words、Delta 2 receptors、Through the C-terminal controls the functional synaptic plasticity、Other sites、Probably involved in morphological synapse formation through the extracellular domain (N-terminal)、It is thought that each driving a separate signaling system。

Graduate students of Nishiyama Mr. of paper is now Accept the Autophagy magazine。Congrats。

The relationship between the nerve cell death and autophagy has been attracting attention。For example,、In lurcher mutant mice、When the Delta 2 receptor is constantly activated、Neurodegenerative be seen along with the enhancement of autophagy in Purkinje cells。This molecular mechanism has been conducting research in our laboratory。

In this research、The Atg5 gene is essential for autophagy pathway has been created and studied the Purkinje cell-specific defects are not mice。Prior to denaturation of the Purkinje cells Interestingly、Swelling of the axons is observed、Image intracellular membrane structure is accumulation was observed in tumor most。It is considered an important finding in considering the origin and role of the auto phagocytosis transchromosomic in nerve cells。(Is a joint research with Ken Watanabe Medicine and Dentistry of Ken Mizushima Hokkaido University。）

Journal of Physiology paper is Assistant Professor Kakegawa (London)Now Accept to。Congrats。

Delta 2 receptors、Although it belongs to ionotropic glutamate receptor family、Whether it is unknown still what is functioning as an ion channel。In this paper、The channel domain was mutated to "channel dead" delta 2 receptor、By expressing the delta receptor null mutant mice、It was the challenge of this problem。

Surprisingly、"Channel dead" delta 2 receptors、As with normal delta 2 receptor、From to restore the cerebellum LTD failure、Delta 2 receptor is now for the first time clear that does not function as an ion channel。

Koda lecturer of paper is Publish to Eur J Neurosci、It was on the cover。Congrats。

Although the delta receptor is a molecule that controls the long-term depression (LTD) which is a basis course of motor learning in the cerebellum、It was so far unknown how the function to。In this paper、To deficient cerebellum the delta 2 receptor、By introducing a delta receptor with a viral vector、The LTD succeeded to be restored。

Interestingly、When the deficient C-terminus of the intracellular domain of Delta 2 receptor、That the LTD induction function of the delta 2 receptor is lost it was found。As a result、Delta 2 receptors、Rather than ionotropic glutamate receptor、Function as metabotropic receptors that transmit signals through the intracellular domain was suggested。

Iijima an assistant of the marriage celebration was conducted by Alice Garden。You happy!!

Joint research with RIKEN BSI FuruichiKen is now Accept the Journal of Neuroscience magazine。Kakegawa Assistant Professor has electrophysiological analysis of parallel fibers over Purkinje cells neurotransmission another Lobule of the cerebellum。

A paper by Associate Kakegawa J Physiol (London)Now in press in。Congrats。

This paper、By L7 promoter、By mating transgenic mice and delta 2 receptor null mutant mice expressing specific delta receptor in Purkinje cells、The recovery degree of various phenotypes of null mutant mouse thing was electrophysiological and morphological study。

Surprisingly、Not only normal delta 2 receptor、Delta 2 receptor mutated Q / R site to determine the Ca permeability in the channel pore also、It found that to recover most of the phenotype。From this it、Delta 2 receptor is now clear that the amino acid sequence does not function as a Ca channel but is expected to form a Ca ion transmission channel pore of。

Work on the function of Cbln family molecules of special research assistant Iijima、Eur J Neurosciにin pressに。Congrats。

Kameyama-kun of self-directed learning announcement of medical students was awarded the Excellence Award。Congrats。Kono's Hongo-kun of the research report also was very great。

To in press in the new book "The Glutamate Receptors" in the Review of Yuzusaki about the delta receptor The Humana Press。

First Papers is Accept in Eur J Neurosci of graduate doctoral second year Ishida's this classroom。In a systematic work on the involvement of MAPK in the cerebellum LTD expression、Unlike the hippocampus LTD that p38MAPK are involved、In the cerebellum LTD p42 / 44MAPK be involved、Article its action point showing that it is not a mGluR1 previously thought。Congrats。

Kakegawa assistant 2006 the Japan Neuroscience Society Award Winner。Congrats!

Matsuda (Keiko) assistant、Return from maternity leave。New delphilin isoforms (N-terminal extra with new PDZ domain) paper on becomes Accept to J Biol Chem during which。Congrats。

5Celebration meeting of 26 days Kakegawa assistant marriage month (and the second time bowling tournament)。You happy!

We were working together at Yuzusaki Research Institute in the United States St. Jude Children's Research Hospital era、Promotion from Hirai-san Kanazawa innovation brain science project research area assistant professor in Gunma nerve Department of Physiology Professor。Congratulations!。5Was a celebration meeting a month 19 days。

Go Kakiya's special researcher in Niigata University School of Medicine MSc。Farewell party on March 23, I wish success and good luck。

Newly Sakae Narumi in April on behalf of the、Participate in the lab as a special researcher。
Kiyoshi Katsumata of doctoral one year from the Keio University anesthesiologists participated in lab。
Participated Shiro Satomi to Keio University MSc 1 year。

In PNAS magazine、To work on Kakegawa assistant of the cerebellum LTP is Accept。Congrats。
Paper is to Accept the PNAS journal on special research assistant of RNA binding proteins Hzf Iijima。Thank you for your good work。

Work of Cerebellin is accepted in Nature Neuroscience magazine。11Published in the month No.。Jim Morgan Research of St. Jude Children's Research Hospital、Joint research with Ken Watanabe of Hokkaido University。Lead author Hirai's currently Kanazawa innovation brain science project study area Associate Professor。ladies and gentlemen、Cheers for hard work was the。

9Graduate students of Ishida to month 25 days (nee：Ito) Aya's wedding。You happy!

Kondo-san to Eur J Neurosci magazine paper published in the (visiting researcher)。While it works on phosphorylation sites of the delta 2 receptor、Obtained had data was finally saw the light of day when the Kondo-san in the lab of St. Jude Children's Research Hospital was studying。 Congrats。

6The First bowling tournament a month 13 days。Yuzusakihai the assistant of hand Kakegawa。

6Award Yuzusaki the Kitasato Prize in month 11 days。

Matsuda (Shin) assistant of paper was laid in JBC。Paper is about the meeting and the three-dimensional structure of the AMPA receptor。 Congrats。

Transgenic Invited review of Yuzusaki was laid in Research。Transgenic rescue mouse Delta 2 receptor (EMBO R, 2005)Review is containing the data that was not written to。

4Aya Ishida doctoral than the moon、Kyoichi Emi MSc、Kamegawa Yuichi is now to participate in the new lab。

In addition to the Yoshiaki Tagawa of the School of Medicine four years who participated in the study from last year、School of Medicine three years of Tadashi Kameyama、Maya Kono、Amane Hongo now also to enter the lab。

4We gave a newcomer welcome party on the 26th month。

Delta 2 receptor、Unlike other glutamate receptors、Paper revealed that it is not probably using the extracellular ligand-binding consensus site is now Accept in EMBO Reports。

And Kakiya's Research Fellow、Updated Kondo's visit researcher to the member list。

East-kun of the master's program became a graduate-employment。Congrats。Farewell party was excitement in Monjayaki(?)。

Ogawa-kun was enrolled in the new master's program。Also、Nishiyama Mr. terms with God-kun of the University of Tokyo psychiatry than doctoral one year now to participate in the lab。

Matsuda (Shin) paper on the intracellular sorting of the assistant of the delta 2 receptor has been published in the European Journal of Neuroscience。

Iijima-kun as COE special research assistant professor is now able to participate in the new lab。
4Month returned home from the United States St. Jude Children's Research Hospital than one day、Kakegawa-kun was the Society for the Promotion of researcher became appointed as assistant。

Finally arrived at the Keio on February 16, moving luggage is over the Pacific Ocean from the United States of laboratory。It was moving cheers for hard work。Also arrived safely about 120 mice。

Matsuda on NR3B subunit (Megumi) assistant of the paper is now Accept the Journal of Neuroscience。

8Hirasawa assistant at the end of the month、9End of the month at HisashiNaru assistant with the study abroad、It became a retirement。Instead Koda full-time lecturer and Motohashi co-researcher from the University of Tokyo from September 1、10Matsuda than US St. Jude Children's Research Hospital from 1 day a month (Shin) assistant and Matsuda (grace) is assistant became the appointed。

Yuzusaki is appointed by the US St. Jude Children's Research Hospital Developmental Neurobiology department as successor of retirement has been Shodo Kaneko professor。2004Until February year concurrently with the Institute。It begins new classroom system。