Synapses, which are places for information transmission between nerve cells, are formed by proteins called synapse organizers.、Responsible for precise control of memory and movement。In this study、Based on the structure of synapse organizer proteins、we designed an artificial synapse organizer、and have developed an artificial synapse connector CPTX that can connect excitatory synapses in a wide range of the nervous system.。.、.、When CPTX is administered to the causative region of disease model mice caused by synaptic disruption such as Alzheimer's disease, or spinal cord injury、Reduced synapses recover within a few days、Found to significantly improve the condition。This research was the first successful achievement in the design of artificial synaptic connectors and their application to diseases.。Depending on the design of the artificial synapse connector, it is possible to control various types of neural circuits.、It is expected to lead to basic research and future therapeutic applications for psychiatric and neurological disorders.。For the summary,Click here. 。
This is an international joint research between Japan, the UK and Germany.、Dr. Hiroyuki Sasakura of Aichi Medical University、Professor Tsunesei Takeuchi、Dr. Elegheert, MRC Institute for Molecular Biology, UK、Professor Aricescu、Dr. Song of the German Center for Neurodegenerative Diseases、It is the result of the research with Professor Dityatev and his group.。Also、Assistant Professor Suzuki Kondo、Lecturer Keiko Matsuda、Associate Professor Wataru Kakegawa、Researcher Eriko Miura、Assistant Professor Shintaro Otsuka、 Former medical student Tatsuya Shimada、and many other researchers of our lab have contributed to this work。
For Press releaseClick here. 。

The illustrations were drawn byMr. Mizutani Michi.。

"Dynamic control of brain function by scrap and build" The 5th group meeting was held on the Web for the first time from August 17th to 19th.。This year, Yuzuzaki Lab was in charge of the group meeting.。The team of、Assistant Professors Ishikawa,、Yamazaki,、and Suyama,、with Secretaries Hirayama and Yoshikawa, worked together in preparation for the very first online group meeting and finished successfully.。

Membrane Surface Trafficking of Glutamate Receptors

8A public panel discussion "Brain Science and Society in 2050" was held on the 2nd of March using Zoom webinar.。It is a future plan, outreach, industry-academia collaboration promotion committee collaboration project of the Japanese Society of Neuroscience.。It was also delivered to YouTube at the same time。Lecturer Ishida participated as a panelist from the laboratory。

The 43rd Japan Neuroscience Congress (Chairman Kitazawa)、It was held from July 29th to August 1st as the first web event in response to the corona disaster.。From the laboratory, Yuzuzaki will be the speaker of the special lecture and symposium (control of brain function and formation of pathological conditions by creative destruction).、Keiko Matsuda as a speaker at the Japan-China Neuroscience Society Joint Symposium、Ishida is a symposium organizer and performer (learning from pathological models)：(Cross-cutting approach to understanding developmental disabilities)。

Cerebellar learning theory-50 years of MAIT theory

see Resume in the Review Club folder.

Brain control of humoral immune responses amenable to behavioural modulation
Zhang X, You B, Yuan Y, Zhang L, Hu L, Jin S, Kang B, Liao X, Sun W, Xu F,
Zhong Y, Hu J, Qi H. Nature. 2020 May;581(7807):204-208. doi:
10.1038/s41586-020-2235-7. Epub 2020 Apr 29. PubMed PMID: 32405000.

Nagoya University (Faculty of Medicine on February 19)、20Faculty of Science on the dayAt)、Yuzu Saki gave a lecture。Title is "In the beginning there synapse - synaptic modification mechanism as the foundation of psychiatric and neurological disorders" was。

Based on the agreement of AMED and MRC3rd UK-Japan Neuroscience Symposium is EdinburghAt February 3, 2009 - it was held in 5 days。Ishida from the classroom gave a oral presentation announcement。Yuzusaki took part as organizer。In the forward path、Located in CambridgeMRC Lab of Molecular Biology (LMB is the birth place of modern molecular biology where many fundamental discoveries, such as double helix structure of DNA, muscle contraction mechanisms and viral capsid stuctures, are made.)A visit、It gave a joint research meeting。

143rd Brain Club is Yasushi Okada teacher (RIKEN cell polarity govern research team、The University of Tokyo Graduate School of Science、We welcome the University of Tokyo Graduate School of Medicine)。Presentations was "axonal transport of molecular mechanism to explore in the super-resolution, single-molecule imaging"。After the meetingAGITO in Yotsuya 3-chomeI had a fun discussion。

So could not year-end party of yuzu Saki Research in convenience last year、This year made a New Year's party at the lab。There was also a quiz planning using Kahoot at the initiative of the conference-kun。PhotoClick here. 。

Welcomed the Shimogori Tomomi teacher of RIKEN CBS brain development molecular mechanism research team made a second 142 times Brain Club。演題は「Activity dependent protein dynamics for selective dendrite morphogenesis in developing neuron」でした。After the meeting, I moved to KagurazakaCampañolaI had a fun discussion。