Lecturer Ishida will be promoted as a team leader of RIKEN CBS on July 1st.。She will be leading the Laboratory for Brain Development and Disorders、and their goal is to connect molecules and circuits to untangle developmental disorders、.。Congratulations! (Dr. Ishida is the very first graduate student of Yuzuzaki Lab at Keio.)。

Even in everyday life、Even in nature world、When making something new、Oftentimes, you must break the old one before that。When the morphology of nerve cells changes in our brain according to the developmental stage and memory / learning、Cooperately、It is always accompanied by the destruction of nerve cells and the extracellular matrix around them.。As one of the mechanisms responsible for such a scrap and build phenomenon、The secretion of lysosomes from nerve cells is raising attention。Although lysosomes are usually known as the final digestion site for aging intracellular products,、,、We have found that, In response to hyperactivity, it releases the synapse-forming molecule Cbln1 with the lysosome enzyme, which is the content of the lysosome (Neuron 2019).。In this review paper、we overviewed lysosome secretion in the nervous system。Dr. Ibata, who has transferred to St. Marianna University, is the first author.。

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

Casarotto,…Eero Castrén

Cell 184:1299-1313, 2021 

We are、looking for a few researchers (technicians) who can assist our research as a member of our team with a sense of responsibility and cooperation.。It is necessary that you are familiar with basic molecular biology technology, fluent in speaking Japanese, hopefully, in reading as well.、We will also teach you what you need here。Those who have experience in mouse breeding and management、as well as those who are interested in public relations are even more welcome。

[Job title / term]
Researchers (technicians)：Employment with Grants-in-Aid for Research。
Depending on your achievements and experience、there may be a certain trial period。

[Starting time]
Respond to consultation。

【Work location】
Shinanomachi, Shinjuku-ku, Tokyo 35 Keio University School of Medicine, Integrated Medical Science Research Building

【treatment】
Follows Keio University regulations。Complete with various insurance。It is also possible to use a recreation center, etc.。

[Items to be submitted](Free format)
・ Resume (with photo) (Please state the skills and knowledge you have acquired so far, as well as Japanese language proficiency.。）
・ If there is a reference, please provide name and contact information (e-mail address)。

[Application deadline]
We hold an interview after the document screening.、Applications will be closed as soon as the suitable candidate is found。
Thus, there is no specific deadline.、If you are interested, please e-mail us first.。

【To apply】
Please e-mail with the application documents attached、to our laboratory secretary, Ms. Akiyo Hirayama (hirayama@keio.jp) with cc to Ms. Kaori Yoshikawa( kyoshikawa.a3@keio.jp).。

Keio University School of Medicine HP "Features"takes up the research of our laboratory。

Assistant Professor Takeo's paper”GluD2- and Cbln1-mediated competitive interactions shape the dendritic arbors of cerebellar Purkinje cells”,was published in Neuron.。It was her work while studying abroad at Dr. Liqun Luo Lab at Stanford University.。Congratulations!。

Professor Yuzaki was featured in the digital edition of Asahi Shimbun, in the series of、Keio University and Asahi Shimbun joint project "This piece of research and life".。
It ’s a familiar cell for us、but it's beautiful。Assistant Professor Takeo took this artistic photo。

Rett syndrome is caused by a deletion or decrease in the amount of a nuclear protein called MeCP2 that binds to methylated DNA.、Highly associated with autism spectrum disorders。On the other hand、It is known that even if the amount of MeCP2 protein is increased, mental developmental disorders occur.。However、Until now, it was not well understood how the amount of MeCP2 causes mental illness.。In this study, the amount of MeCP2 regulates the three-dimensional structure of chromatin in nerve cells.、The possibility of changing the expression of various genes was clearly shown using a mouse model.。This work is based on the research conducted by Lecturer Ishida at Zogbhi Lab while studying abroad.、After returning to Japan, it wasPublished in J Neurosci.。

Formed for the first time in TaiwanTaiwan Society for Neuroscience（TSfN)Tournament is between September 11th and 13th、Held as a hybrid of real conference and web conference。Yuzuzaki as Plenary Talk、「How to Build Synapses: New Mechanisms by Extracellular Scaffolding ProteinsI gave a lecture on。After playing a pre-recorded video lecture at the venue、A lively question-and-answer session was held by connecting Japan and Taiwan online in real time.。

Held from August 31st to September 2nd as a real and web hybrid tournament in Okayama61st Annual Meeting of the Japanese Neurological SocietyIn、"Basic-Clinical" at the Japan Neurological Society (clinical society of neurology) and the Japan Neuroscience Society / Japan Neurochemistry Association、Cross-society symposium：Let's turn our attention to basic science for the treatment of future diseases "。Yuzuzaki says "Recommendation of basic researchI gave a lecture entitled "。

Synapses, which are places for information transmission between nerve cells, are formed by proteins called synapse organizers.、Responsible for precise control of memory and movement。In this study、Based on the structure of synapse organizer proteins、we designed an artificial synapse organizer、and have developed an artificial synapse connector CPTX that can connect excitatory synapses in a wide range of the nervous system.。.、.、When CPTX is administered to the causative region of disease model mice caused by synaptic disruption such as Alzheimer's disease, or spinal cord injury、Reduced synapses recover within a few days、Found to significantly improve the condition。This research was the first successful achievement in the design of artificial synaptic connectors and their application to diseases.。Depending on the design of the artificial synapse connector, it is possible to control various types of neural circuits.、It is expected to lead to basic research and future therapeutic applications for psychiatric and neurological disorders.。For the summary,Click here. 。
This is an international joint research between Japan, the UK and Germany.、Dr. Hiroyuki Sasakura of Aichi Medical University、Professor Tsunesei Takeuchi、Dr. Elegheert, MRC Institute for Molecular Biology, UK、Professor Aricescu、Dr. Song of the German Center for Neurodegenerative Diseases、It is the result of the research with Professor Dityatev and his group.。Also、Assistant Professor Suzuki Kondo、Lecturer Keiko Matsuda、Associate Professor Wataru Kakegawa、Researcher Eriko Miura、Assistant Professor Shintaro Otsuka、 Former medical student Tatsuya Shimada、and many other researchers of our lab have contributed to this work。
For Press releaseClick here. 。

The illustrations were drawn byMr. Mizutani Michi.。

"Dynamic control of brain function by scrap and build" The 5th group meeting was held on the Web for the first time from August 17th to 19th.。This year, Yuzuzaki Lab was in charge of the group meeting.。The team of、Assistant Professors Ishikawa,、Yamazaki,、and Suyama,、with Secretaries Hirayama and Yoshikawa, worked together in preparation for the very first online group meeting and finished successfully.。