Ms. DILINA Tuerde、JSPS Special Fellow for Foreigners(PD)Adopted by。Congratulations!。For outstanding young researchers from other countries who have just obtained their Ph.D.、This program provides opportunities to engage in research at Japanese universities and other research institutes.。Only 8 people in all of Japan are employed in biological sciences.。

4th year doctoral student Kazuya Nozawa's dissertationOnline version of Neuron.。For Press releaseClick here. 2022。
by improving Expansion Microscopy (ExM), a high-resolution microscopy technique、Molecules that determine the individuality of synapses in the brain at the nano level (one millionth of a millimeter is one nanometer)：nm) revealed the structure of。

The neural network that underpins the functioning of the brain、Nerve cells are connected to each other by synapses。Various molecules that connect synapses are、Because it is concentrated in a narrow region of about 100 to 1000 nm in the synapse、Its detailed distribution cannot be observed with the resolution of conventional optical microscopes (approximately 200 nm).。there、Nozawa-kun, together with Hayashi-san、We further improved ExM, a technology that expands the specimen itself to about 1000 times its volume.、By optimizing for synaptic observation、For the first time, we succeeded in clarifying the structure and interrelationships of molecular groups that connect excitatory synapses in mouse neural networks at the nano-level.。According to the comment, 、A group of synaptic molecules that bind to neurexin (neurexin ligand)、It was discovered that they accumulate as units of ``nanodomains'' of several tens of nanometers each within synapses.。further、Depending on the type of neurexin present at the presynaptic site、It has been found that the arrangement of nanodomains of post-synaptic synaptic molecules and glutamate receptors is determined。
From the results of this research、The characteristics of synapses that support brain function、It turns out that each specialized synaptic molecule is created by interacting at the nano level.。These molecular groups have been reported to be associated with many psychiatric disorders and neurodevelopmental disorders.、It is expected that the results of this research will lead to an understanding of the pathogenesis of these diseases and the developmental mechanisms of normal neural circuits.。Taku Sogabe, a fifth-year medical student, also contributed greatly to the development of ExM.。

Assistant Professor Takano received the Young Investigator Award from Keio University School of Medicine in the 4th year of Reiwa.。Congratulations!

GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits
Simon Bossi 1, Dhanasak Dhanasobhon 2, Graham C R Ellis-Davies 3, Jimena Frontera 1, Marcel de Brito Van Velze 2, Joana Lourenço 2, Alvaro Murillo 4, Rafael Lujan 4, Married Mariano 1, Isabel Perez-Otano 5, Alberto Bacci 2, Daniela Popa 1, Pierre Paoletti 6, Nelson Rebola 7
Neuron. 2022 June 10;S0896-6273(22)00457-3.

doi: 10.1016/j.neuron.2022.05.016. ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder.

To understand how neural circuits in the brain work、There is a need for technology that selectively activates glutamate receptors, which are neurotransmitter receptors that control memory and learning.。In this research、While maintaining the original glutamate response ability、Developed a mutant glutamate receptor (metabolized type) activated by an artificial compound。We created mice that actually expressed this artificial glutamate receptor in a specific cell type.、It was shown that the administration of artificial compounds activates metabotropic glutamate receptors in a cell-type selective manner.。It is expected that the understanding of neural circuits will be accelerated by using this new technology "coordination chemogenetics method".。This research was supported by ERATO / CREST, Nagoya University Kiyonaka Lab.、This is a joint research with Kyoto University Hamaji Lab.。Click here for the paper

A translation of the 3rd edition of the original Brainbook "Mieru Brain" has been published.。It is a general book that explains the basic structure and function of the brain in an easy-to-understand manner with CG, illustrations and photographs.。It is a general book that explains the basic structure and function of the brain in an easy-to-understand manner with CG, illustrations and photographs.。It is a general book that explains the basic structure and function of the brain in an easy-to-understand manner with CG, illustrations and photographs.。

Permalink that is delivering "Study of Brain Studies"Permalink that is delivering "Study of Brain Studies"Permalink that is delivering "Study of Brain Studies"Permalink that is delivering "Study of Brain Studies"Permalink that is delivering "Study of Brain Studies"、Permalink that is delivering "Study of Brain Studies"Permalink that is delivering "Study of Brain Studies"Permalink that is delivering "Study of Brain Studies"、 School of Medicine, Keio UniversityPermalink that is delivering "Study of Brain Studies"Permalink that is delivering "Study of Brain Studies"Permalink that is delivering "Study of Brain Studies"Permalink that is delivering "Study of Brain Studies"Permalink that is delivering "Study of Brain Studies"Permalink that is delivering "Study of Brain Studies"。Permalink that is delivering "Study of Brain Studies"Permalink that is delivering "Study of Brain Studies"Please spread the information so that you can watch it.。

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Fromthe President of the Japan Neuroscience SocietyGreetings at the beginning of the year2022。Let's all do our best this year, too!

12/8/2021, we held our 146th Brain Club and(welcomed Dr. Shigeki Watanabe of the Department of Cell Biology, Johns Hopkins University School of Medicine as the speaker。His talk was titled "Mechanisms of Synaptic Transmission."、He talked about the latest endocytosis mechanism at the presynaptic mechanism using the quick freezing method.。This time, the online seminar was held over 2 days, across the time difference of 14 hours.。(The snapshot after the personal interviews the day after the seminar)。

Dr. Takeo's review "Purkinje Cell Dendrites: The Time-Tested Icon in Histologyhas been published in the book "Cerebellum as a CNS hub" from Springer.。This review summarizes the results of the research on、dendrite development in neurons and its molecular mechanism to the date, Purkinje cells as a model、including Dr. Takeo's own work.。

Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo
Taisuke Miyazaki, Megumi Morimoto-Tomita, Coralie Berthoux, Kotaro Konno, Yoav Noam, Tokiwa Yamasaki, Matthijs Verhage, Pablo E Castillo, Masahiko Watanabe, Susumu Tomita.
eLife 2021;10:e59613

The 145th Brain Club was held with Dr. Kenichi Oki, Graduate School of Medicine, The University of Tokyo, Department of Integrated Physiology.。Titled "Mouse Vision / Monkey Vision"、Using the latest large-scale Ca imaging technology and tracing technology、He talked about the differences in visual information processing pathways from the retina to the higher visual cortex.。Mouse is a mouse、At the same time different from non-human primates in many ways、I learned the common points as the calculation principle.。This time as well, it was a hybrid seminar at Zoom at the same time as the face-to-face meeting.。