Fromthe President of the Japan Neuroscience SocietyGreetings at the beginning of the year2022。Let's all do our best this year, too!

12/8/2021, we held our 146th Brain Club and(welcomed Dr. Shigeki Watanabe of the Department of Cell Biology, Johns Hopkins University School of Medicine as the speaker。His talk was titled "Mechanisms of Synaptic Transmission."、He talked about the latest endocytosis mechanism at the presynaptic mechanism using the quick freezing method.。This time, the online seminar was held over 2 days, across the time difference of 14 hours.。(The snapshot after the personal interviews the day after the seminar)。

Dr. Takeo's review "Purkinje Cell Dendrites: The Time-Tested Icon in Histologyhas been published in the book "Cerebellum as a CNS hub" from Springer.。This review summarizes the results of the research on、dendrite development in neurons and its molecular mechanism to the date, Purkinje cells as a model、including Dr. Takeo's own work.。

Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo
Taisuke Miyazaki, Megumi Morimoto-Tomita, Coralie Berthoux, Kotaro Konno, Yoav Noam, Tokiwa Yamasaki, Matthijs Verhage, Pablo E Castillo, Masahiko Watanabe, Susumu Tomita.
eLife 2021;10:e59613

The 145th Brain Club was held with Dr. Kenichi Oki, Graduate School of Medicine, The University of Tokyo, Department of Integrated Physiology.。Titled "Mouse Vision / Monkey Vision"、Using the latest large-scale Ca imaging technology and tracing technology、He talked about the differences in visual information processing pathways from the retina to the higher visual cortex.。Mouse is a mouse、At the same time different from non-human primates in many ways、I learned the common points as the calculation principle.。This time as well, it was a hybrid seminar at Zoom at the same time as the face-to-face meeting.。

Assistant Professor Tetsuya Takano was selected as a third-year member in the JST PRESTO "Cell Interactions in Multicellular Systems and Their Dynamics" area (Yoshiko Takahashi Research Supervisor).。Congratulations!

The 144th Brain Club Seminar, which had been postponed for a year and a half from February 2020 due to the influence of COVID-19, was held.。The talk was titled "human-specific program that controls the development and evolution of the cerebral cortex" by Professor Ikuo Suzuki of the Graduate School of Science, the University of Tokyo.。

In addition to face-to-face lectures given in ample space and under infection-protection settings、it was a hybrid event with real-time streaming via Zoom.。
Both face-to-face and Zoom sessions were lively with questions and answers、We all enjoyed the Brain Club after a long absence。(We took off our masks only when taking this picture. We held our breaths, then。）

Assistant Professor Tetsuya Takano won、2021Annual Award of the Japan Neuroscience Society Encouragement Award!Congratulations!!。The award-winning achievements、will be published as a review in Neuroscience Research。It was also adopted for the cover photo。

As a member of our research team、We are looking for another person who can promote research together.。You need to be familiar with basic molecular biology techniques,、We will also teach you what you need here。Those who have experience in mouse breeding and management、as well as those who are interested in public relations are even more welcome。

Employment with research grants。Treatment is in accordance with Keio University regulations。Complete with various insurance。It is also possible to use a recreation center, etc.。

・ Resume (with photo) (Please describe so that you can understand the skills and knowledge you have acquired so far。) Free format
・ If there is a reference, please provide name and contact information (e-mail address)。

We hold an interview after the document screening.、Applications will be closed as soon as the suitable candidate is found。
Please e-mail with the application documents attached、to our laboratory secretary, Ms. Akiyo Hirayama (hirayama@keio.jp) with cc to Ms. Kaori Yoshikawa( kyoshikawa.a3@keio.jp).。

The work of Dr. Matsuda (Associate Professor, University of Electro-Communications, Visiting Associate Professor, Keio Physiology)has been accepted by J Biol Chem.。Congratulations!。

Long-term repression phenomenon (LTD), which is considered to be the basic course of memory and learning)Is the number of AMPA receptors in the postsynaptic、It is believed that its molecular level entity is reduced due to internalization (endocytosis) by neural activity.。By phosphorylating the intracellular domain, which is conventionally different for each subunit of AMPA receptor、It was thought that the endocytosis of the AMPA receptor itself was regulated。On the other hand、Phosphorylation of TARP that binds to AMPA receptor regardless of AMPA receptor subunit、From binding AP-2, which is essential for endocytosis, to the AMPA-TARP complex、It was a mystery how AMPA receptor subunits could control LTD.。In this paper、The phosphorylation status of the GluA1 subunit of the AMPA receptor、Discovered to change the strength of the bond between TARP and AP-2。Although TARP cannot distinguish the subunits of AMPA receptors、AP-2 can distinguish the phosphorylation state of each subunit of AMPA-TARP receptor.。

Lecturer Ishida will be promoted as a team leader of RIKEN CBS on July 1st.。She will be leading the Laboratory for Brain Development and Disorders、and their goal is to connect molecules and circuits to untangle developmental disorders、.。Congratulations! (Dr. Ishida is the very first graduate student of Yuzuzaki Lab at Keio.)。

Even in everyday life、Even in nature world、When making something new、Oftentimes, you must break the old one before that。When the morphology of nerve cells changes in our brain according to the developmental stage and memory / learning、Cooperately、It is always accompanied by the destruction of nerve cells and the extracellular matrix around them.。As one of the mechanisms responsible for such a scrap and build phenomenon、The secretion of lysosomes from nerve cells is raising attention。Although lysosomes are usually known as the final digestion site for aging intracellular products,、,、We have found that, In response to hyperactivity, it releases the synapse-forming molecule Cbln1 with the lysosome enzyme, which is the content of the lysosome (Neuron 2019).。In this review paper、we overviewed lysosome secretion in the nervous system。Dr. Ibata, who has transferred to St. Marianna University, is the first author.。