Osaka Bioscience Institute "new group of molecules -C1q protein to control the synapse formation and functional plasticity and delta receptor" lecture at the monthly seminar of (OBI) and was done by Yuzusaki。

This is a review article by Dr. Yuzaki published in The Special Issue of the Current Opinion in Neurobiology on "Synaptic function and regulation (April issue in 2011)To "、Review of Yuzusaki was published on C1ql1 family of molecules is a new synapse formation and maintenance factor Cbln1 and its related protein。Thing that summarizes the work so far of the laboratory。

From Kyoto Hirokawa Shoten、"Transport Zoom of the world - from the headwaters of the membrane transport studies to the future" was out。Is a book that covers the history of the study of channel transporter and its related molecules until recently topic。Yuzusaki has shared writing to the section of the ligand-gated channels of Chapter 2 ion channel。For details please Click here. 。

RIKEN Brain Science Institute (RIKEN-BSI)BSI-Seminar Series is the flagship seminar (BSS)Yuzu Saki gave a lecture at。6Month 9 days - we were given the opportunity to interact with researchers in many of BSI over the two days of the 10 days。

Matsuda (Keiko) and Yuzusaki was featured in the "Japanese researchers placed on the science."。

In the link below you can read the digital edition (article of Yuzusakiken is 28 pages)。

From “Japanese Scientists in Science 2010.” Reprinted with permission from AAAS.“

Probing TARP modulation of AMPA receptor conductance with polyamine toxins.

Keiko Matsuda's paper There are published in the European Journal of Neuroscience、In this issue Featured Article. It was chosen to。Sudhof Dr. told me to write a comment article。



It is a follow-up report of a strong synapse formation and maintenance molecule Cbln1 in the cerebellum, which we have already reported。Although last year's Science paper (2010), the postsynaptic receptors has reported that it is a GluD2、In this paper presynaptic side of the receptor Neurexin (Nrx)It is、In addition brain regions (hippocampus and cerebral cortex) other than the cerebellum any similar molecule (Cbln2 and GluD1)It reported that has a similar synapse formation action。Nrx is known as the gene responsible for autism、But as its receptor, such as Neuroligin and LRRTM it has been known、Nrx-Cbln1-GluD2 is、It is possible to control the synapse formation was found by an independent molecular mechanisms and these molecules。

Baby girl of the second child was born in Kakegawa Assistant Professor。It is 撫菜 (shepherd's purse) chan。Congrats!!

The neural substrates of rapid-onset Dystonia-Parkinsonism
Nature Neuroscience 14.357–365 (2011)
http://www.nature.com/neuro/journal/v14/n3/abs/nn.2753.html

β-Adducin Is Required for Stable Assembly of New Synapses and Improved Memory upon Environmental Enrichment

Neuron.. 2011 Mar 24;69(6):1132-46.

http://download.cell.com/neuron/pdf/PIIS0896627311001565.pdf?intermediate=true

A paper by Kakegawa has been published in Nature Neuroscience (online edition 04 April).。Is a joint research with Kyushu University of Hamase Associate Prof.。

There are many different types of memory、Memory associated with motor skills such as a human of sports and playing a musical instrument activities、Cerebellum of neural circuits are involved。However、Unknown Many points about the molecular mechanisms that control the storage in the cerebellum synapse、For example, we do not know well why to reduced motor learning ability with age。

So far、By protein Cbln1 secreted by neurons in studies using mouse binds to the delta type 2 glutamate receptor (delta 2 receptor)、I had discovered that to control the synapse formation in the cerebellum。Nozawa-kun, together with Hayashi-san、By amino acid D- serine abundant in the cerebellum of juvenile mice bind to delta 2 receptor、To promote the movement memory and learning in the synapse、It was revealed in experiments。In fact D- where serine was prepared and analyzed a genetically modified mouse which can not bind to the delta 2 receptor、Movement memory and learning ability in juvenile life had been significantly reduced。

Binding model of the D- serine and delta 2 receptor、Also believed to be fitted to the people。This finding is、Thing to provide a useful knowledge in understanding the movement memory and learning process in the early childhood of people。Also、Delta 2 receptor is expressed throughout life、By controlling the D- serine pathway、future、There is a possibility that can efficiently to promote motor learning in adults。

Picked up in Yomiuri Shimbun、Nikkan Kogyo Shimbun、It was featured in such as Asahi newspaper children。

JST Press ReleaseHere。

The paper by Emi as the first authorhas been accepted by Neurochem ResNow and in press in。

This thesis has developed a new rapid blink conditioning protocol for the cerebellar motor learning function measurement。But it is scheduled to come out let me know after、The time being Congratulations。