Keiko Matsuda's paper There are published in the European Journal of Neuroscience、In this issue Featured Article. It was chosen to。Sudhof Dr. told me to write a comment article。

It is a follow-up report of a strong synapse formation and maintenance molecule Cbln1 in the cerebellum, which we have already reported。Although last year's Science paper (2010), the postsynaptic receptors has reported that it is a GluD2、In this paper presynaptic side of the receptor Neurexin (Nrx)It is、In addition brain regions (hippocampus and cerebral cortex) other than the cerebellum any similar molecule (Cbln2 and GluD1)It reported that has a similar synapse formation action。Nrx is known as the gene responsible for autism、But as its receptor, such as Neuroligin and LRRTM it has been known、Nrx-Cbln1-GluD2 is、It is possible to control the synapse formation was found by an independent molecular mechanisms and these molecules。