Suzuki Kunimichi Mr.、Yukari Takeo、Tim Budisantoso kun was elected Fellow of the Society for the Promotion of Science (PD and foreign researchers)。Congrats!

One of the formation and function of the excitatory synaptic and inhibitory synaptic input to the nerve cells is believed to have been controlled in conjunction with each other, but we do not know well the entity。Cerebellar parallel fibers and secretion in this paper、Is Cbln1 to strongly promote the formation of a functional excitatory synapses between Purkinje cell - parallel fibers、It has revealed that to suppress the formation and function of inhibitory synapses intervening neural over Purkinje intercellular。This studyEuropean Journal of Neuroscience.。Ishida's graduate student OB's work centered on the (currently studying in the United States)。

Was held Keio Medical Science Society meeting, new academic area · Brain Club mini-symposium co-sponsored the "Neuronal function and dysfunction mediated by protein glycosylation" on January 8,。Michael D of US Pfizer neuroscience department. Dr. Ehlers、Shi invited Alexander Dityatev Dr. Magdeburg University / Germany neurodegenerative disease center、Lively debate took place。

January 2014 issue of Comprehensive Rehabilitation ( Vol.42 No.1)"Synaptic plasticity as the foundation process of nerve function recovery" review of the Koda-Yuzusaki to - "Current Topics featured advances in brain science" was published in the。

Long-term depression is one of synaptic plasticity (LTD; Long-Term Depression）は、By the number of AMPA receptors in dendrites decreases、Efficiency of information transfer in the synapse is the phenomenon to be reduced in the long term。But we do not know well whether the number of AMPA receptors is controlled by any mechanism。Elucidation of the mechanism is not only a better understanding of brain function、It is expected to lead to the development of the understanding and treatment of a variety of brain diseases。

It will be transported to the cell membrane (cell surface) after present in the cell membrane "membrane protein" that is synthesized in the cell。Membrane protein receives information extracellular、It plays a function of transmitting to the cell。For example AMPA receptors will excite the nerve cells by binding to the glutamate。The amount of membrane protein present on the cell surface、Transport and from within the cell to the cell membrane、It has been precisely controlled by a balance of speed to take from the cell membrane into the cell。This latter process is generally controlled by AP-2 or AP-3A adapter protein。But whether the transport into the cell of the AMPA receptor is controlled how by the adapter protein was a mystery until this。

Matsuda Shinnanji lecturer、In this paper, a protein that binds tightly to the AMPA receptor Stargazin is、We found that it binds strongly when it is dephosphorylated with the enhancement of neural activity in the AP-2 and AP-3A。as a result、AMPA receptor -Stargazin complexes efficiently incorporate into cells、The number of AMPA receptors on the cell surface over a long period of time is reduced。Through this research、So far of the AMPA receptor that is directly linked to memory and learning was a mystery intracellular transport mechanism is now revealed for the first time。Nature CommunicationsIt became the online published in。

Wataru Kakegawa lecturer was awarded a pharmaceutical Foundation research grants Kanae 42nd。10Presentation ceremony was held in the month 30 days。

Symposium was held October 21 to 25 at the Cold Spring Harbor Asia Conferences "Development, Function and Disease of Neural CircuitsYuzu Saki gave an invited talk at "。Furthermore, he gave a lecture at a mini-symposium at Zhejiang University on October 26。

Reports of 2 family of people lacking the 2 receptor deltaNeurologyMagazine.。We mutation of previously mousewould-15JIn exactly the same exon 2 as that report has been deleted。It is characterized by proceeding to the cerebellar atrophy progressive Unlike the mouse in humans。Delta 2 receptor gene locus is known as a very mutation-prone sites、Also families lacking the delta 2 receptor is considered to find what the future。This study is a joint research with Harvard University Ganesh Mochida teacher and Hokkaido University Watanabe laboratory。

I was held on the 11th September 2013 at Yurakucho Asahi HallCentury Symposium of 21st brainAt yuzu Saki gave a general lecture。The day will continue in your opening remarks of the teacher Kanazawa、A special lecture is done than Masao Ito teacher、Continue Osaka University Masatoshi Takeda teacher、Keio University Yuzusaki、Osaka University Tanaka teacher、It is performed lecture in the order of the RIKEN BSI Kuroda teacher、It became the closing by the greetings of Tadaharu teacher。

Was carried out between 13 to 11 September at Pacifico Yokohama86th Conference of the Japanese Biochemical SocietyIn、At the symposium "New Development of the recycling system research in which the cells have"、Matsuda (Shin) lecturer has announced。The Sendai lecturer new aspects of the symposium "membrane traffic：It hosted the control "of the physiological function in cooperation with a variety of cellular events announced。

I was done at 06, 05 September 2013 at the British Embassy"Challenge to neuroscience, disease using next-generation optical microscope" MRC-JST joint workshopYuzusaki to participate in、It gave a discussion about the possibility of future bilateral joint research。

August 31, 2013 at the Nagoya Congress Center as Strategic Research Program for Brain Sciences, comprehensive brain joint planningSymposium entitled "- - for the health of the heart and brain over a lifetime lifestyle brain"Yuzu Saki gave with Okazawa teacher of Tokyo Medical and Dental moderated facilitators of。On the day of RIKEN BSI Shimogori teacher from brain professional challenges E、National Center of Neurology and Psychiatry KUNUGI the teacher、In addition to the Tokyo Medical and Dental Mizusawa teacher、Yamaguchi University psychiatry Watanabe teacher、Following the lecture from Kyoto University Imura teacher、Lively general discussion about strategies for maintaining the "health of the brain and mind over a lifetime" was carried out。