A new paper, based on collaboration with Dr. Arisesuku's lab at Oxford University, 7has been published in Science on July 15th..。In this research、It is a joint of nerve cells and nerve cells to reveal the structure of the bridge that connects the "synapse"、Nerve cells in conjunction with each other was to elucidate the new mechanisms regulating neural network function。The results of this research”It was featured in the "This week in Science“But it was introduced as "Transmitting signals across the synapse (signal beyond the synapse)."。

In the synapse、Glutamate is released from presynaptic、Excitement to the next nerve cell is transmitted by binding to the glutamate receptor of postsynaptic。Furthermore, from presynaptic、It has been revealed in our laboratory that the group of molecules similar to "complement" of the immune system be released to adjust the synaptic function so far。However、And excitement transmission path through the glutamic acid、How to work and how synaptic regulatory pathways by complement family molecules did not know well。

In small brain circuit、Presynaptic releases complement family molecules referred to as CB El N. 1 (Cbln1)、And then binds to a receptor that neurexins (Nrx) present in the presynaptic。On the other hand、Cbln1 will cause the synapse formed by combining at the same time also to the postsynaptic delta type 2 glutamate receptor (GluD2)。Nozawa-kun, together with Hayashi-san、Nrx-Cbln1-GluD2 the structure of the three-party complex that was the first time Tokiakasa。as a result、Cbln1 not only serve to anchor the presynaptic and postsynaptic as adhesive、By adjusting the working styles itself postsynaptic GluD2 the subtle、It was found to control the happened ease of excitement transmission in the synapse (= memory and learning process)。

Complement family molecules · Nrx · glutamate receptors are also present in various brain regions other than the cerebellum。Therefore、This was revealed、Functional regulation mechanism of glutamate receptors by complement family molecules are expected to be working as well in a variety of neural circuits。

Glutamate receptors conformation of the ligand binding site will change by the binding of glutamate。It introduced two His residues to the appropriate site of the ligand binding site、By varying the conformation by Pd molecules administration、Methods of modulating artificially activated, inactivation of ionotropic and metabotropic glutamate receptors has been developed。In this study of the Qing in Kubota teacher of Ken Kyoto University Hamachi your job、6A month 28 daysAOP in Nature Chemistry magazineIt was published as。Yuzusakiken has participated as CREST sharing research。

In this laboratory、With the expansion of the promotion and research of predecessor、Newly started the recruitment of assistant professors 1-2 people。In response to this until the experience、Depending on the qualification, we considereitherIt expects to。Payroll will be determined according to the University rules。

Depending on the changes in the neural activity and the environment、It is selectively enhanced to attenuation particular synapse、Or they are newly formed and removed。This process not only is the basis processes of memory and learning、It has become apparent in recent years is the basis of the change in the connect mix in a variety of psychiatric disorders and developmental disorders。Our laboratory is、Such molecular basis of functional and morphological synaptic plasticity、We aim to elucidate the molecular biology, electrophysiology and behavioral biological。

There is interest in these areas、If it is aimed at the future of the step-up、I'd love to、１）CV、 2) Research proposal、3) Two references (name and contact information)Writing、Kawasaki grapefruit research(name and contact information)Please apply to。For further questions, please contact them, too.。The recruitment will be closed as soon as personnel are found。It was closed。Thank you for a lot of applicants。

Paquet D, Kwart D, Chen A, Sproul A, Jacob S, Teo S, Olsen KM, Gregg A, Noggle S, Tessier-Lavigne M.
Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9
Nature 2016 Apr 27. doi:10.1038/nature17664. [Epub ahead of print]It was not very interesting, but ...。

Keiko Matsuda lecturer and Tim Budisantoso kun is first author of the paper4Online version of Neuron of the month 28 days.。

Kainate receptors of the glutamate receptor、There was particularly high in specific synapses of the hippocampus, an important brain region in memory and learning、The transmission rate that is slow not to other receptors、And the essential role in the integration of hippocampal neural network activity。However、Whether incorporated only to certain synaptic kainate receptors what mechanism、The mechanism was not well understood。In this paper, the、By neurons secrete proteins called the C1ql2 and C1ql3、I found that coming to collect the kainate receptors directly。Also、In the hippocampus of mice lacking the C1ql2 and C1ql3、Kainate receptors is not incorporated into the synapse、Be less likely to occur epileptic seizures was found be given a stimulus to induce epileptic artificially。

C1ql2、C1ql3 is also present in various brain regions、Are considered each by controlling the built-in and function of kainate receptor synaptic neural make up the appropriate neural network activity。The results of this research、It is expected to be of use in the therapy method development and cause elucidation of epilepsy and autism。

This paper、As this month's attention paper of Neuron magazinePreview “Synaptic Menage a Trois”Was introduced as (ThreesomesPlease check out our own meaning of。）

Koda, Associate Prof. promotion as St. Marianna University School of Medicine Department of Physiology professor from April 1。1996St. Jude (but was back in the temporary Tokyo University psychiatry in the middle) Children's Research yuzu Saki Institute at the hospital since joined as the first post-doc at the time of the birth is the beginnings of the oldest founding life member in year。I wish more and more of your success future。

4It belated celebration meeting a month 15 days (farewell party) at the Art Complex。As Koda teacher himself Violin player、Miura (Violin)、Nozawa Jun (Viola)、Great string quartet by Takeo's (Cello) have been made。Photos here→

Papers about the synapse control by the Notch of Takeo Assistant Professor (Adjunct)Scientific Reports.。It is what the work in Tomita Research finally settled。Congratulations!。

Dr. Christophe Mulle (CNRS, University of Bordeaux, Bordeaux, France) gave a talk entitled “Synaptic dysfunction in a memory circuit in models of Alzheimer’s disease” at the 108th Brain Club on March 28th.

This year two teams from yuzu Saki Institute as the first attemptTamagawa Riverside EkidenI participated in。Cbln1 a team and C1qL1 team。Cheers for good work Did!

3month15It gave a farewell Mukaekai of 2016 on the day。This time, the welcome of Nozawa-kun of graduate students (MSc) and conference-kun (PhD)、It is Narumi-kun of the pick-up that who have supported for many years laboratory。Narumi-kun of the favorite food (such as fried) was conducted in the lab a wide variety。Photos here。

ToshibaOnline magazine "has Wereki"Interview article for the general public of Yuzusaki was published in the。

Prof. Ryohei Yasuda (Scientific Director, Max Planck Florida Institute for Neuroscience) gave a talk entitled “Illuminating signal transduction in single dendritic spines” at the 107th Brain Club.