It gave a celebration meeting of Gakushin DC graduate of conference-kun and Nozawa-kun。Congrats!

J Physiology (London)PhD 4 years of the magazineKono's thesisIt came out。
It is well known that the expression of LTP and LTD, which is considered as the basis for processes of memory NMDA receptor (NMDA receptor) is essential。In the previous study、In the important cerebellum to the motor learning、NMDA receptor had been shown to be required for the expression of LTD and LTP。But almost no NMDA receptor expression in the cerebellar Purkinje cells after mature。 paper、NMDA receptors expressed together which cells、How do you control the LTP / LTD? In this paper、Purkinje cells、Granulosa cells、We were challenged with this problem by deficient NMDA receptor gene in each intervening neurons。

Muscle fibers are created by the fusion of myoblasts。Fusion of myoblasts happened even during muscle regeneration after damage, not only during development、It has been strictly controlled。We've discovered as a molecule to control the strengthening and pruning of climbing fibers of the cerebellum so far BAI3 is、Although the muscle fibers to be involved in the fusion of myoblasts had been shown so far、The detailed molecular mechanism was not well understood。In this paper、C1qL4 suppresses the BAI3、Stabilin-2 has revealed that temporally and spatially controlled fusion of myoblasts by activating (→ paper is here.）。Synapse formation is C1qL1-BAI3 in the cerebellum、In the muscle it is extremely interesting that C1qL4-BAI3 to control the muscle formation。As a joint research with Canada's Jean-François Côté laboratory、Conference and Kakegawa, Associate Professor of short-term come the Viviane Tran's a graduate student was indebted to Keio。

River Iwasaki Hiroshi teacher(Kanazawa University of Medicine, Neurosurgery, School of Medicine,)The 130 times Brain Club due to have been made。The title is "analysis of the cerebral cortex formation mechanism using the mouse and ferret"。

On this occasion、For the development of JST ERATO Keio University bases ( "neuro molecular techniques", Kyoto University Hamachi Summary - 2018- 2024) (representative, Kakegawa)、We are looking for new Fellow in the (engineer)。

In this ERATO study、By the creation of chemical biology molecular techniques、The changes in the synapses associated with neuronal activity and memory and learning、And elucidation at the individual protein molecule level。As a result、Changes in the synapses in normal and psychiatric and neurological disorders pathology elucidated at the molecular level、We aim that will lead to new treatment and diagnostic technology。Close collaboration will be required of the Kyoto base for this purpose (bio-organic chemistry and supramolecular chemistry) and Keio base (neuroscience)。

As the business of the special researcher、As Keio base of this studyAdministrative and public relationsWith、Research SupportIt will be carried out。
(1) those who want to try to participate in the Keio base as a member of the research team
(2)Those who have a sense of responsibility and cooperative spirit
(3) If there is a research experience and laboratory work experience (desirable but not required)
Please apply all means。

If you are interested, please prepare 1) CV with、2) 2 people Reference destination (name and contact information)、3)Preferred interview date、and contact Lab Secretaries (hirayama@keio.jp, yuri.y@keio.jp) to Please apply。For further questions, please contact them, too.。.、Please note that Application documents should not be returned。Payroll will be determined according to the University rules。The recruitment will be closed as soon as personnel are found。It was closed。

On this occasion、Conference-kun of the graduate students of this laboratory (D3)And Nozawa-kun (D1)Each but、Japan Society for the Promotion of Science Research Fellow (DC)It became a pre - approved in。Congratulations!。

Yuzusaki reblogged Talk in place the Cold Spring Harbor Asia symposium in Awaji Island。Conference (D3)And Nozawa (D1)Each also、I gave a poster presentation。

Development process of the dendrites of nerve cells are not fully reproduced in the in vitro。For example, juvenile type of neurites but will be trimmed once in the in vivo、This behavior does not know the mechanism may not be observed in in vitro。In this study by observing neurite development process in in vivo by performing intrauterine electroporation、It was revealed that Caveolin-1 controls the development process of dendrites via endocytosis of N- cadherin and L1。It is the job of when the Sendai's has been stayed's with Shikanai to yuzu Saki Research。Paper is here →

Activity-dependent endocytosis of AMPA receptors at postsynaptic sites、which underlies long-term depression (LTD), is thought to mediate certain forms of learning and memory in vivo。However、whether LTD at synaptic levels is causally related to learning and memory at system levels has remained unclear。In thisNeuron paper、using a new optogenetic tool, termed PhotonSABER, which could acutely and reversibly inhibit LTD in a light-dependent manner、we show that LTD at parallel fiber-Purkinje cell synapses、is essential for eye movement-based motor learning in vivo。Dr. Kakegawa, Associate Professor at Keio University、and Dr. Matsuda, Associate Professor at the University of Electro-Communications、performed all experiments with great helps from Dr. Kato, Associate Professor (Tokai Univ.), Dr. Fukasawa, Professor (Fukui Univ) and Dr. Kohda, Professor (St. Mali University School of Medicine)。

TheVideo Abstract has been published in Neuron.。YouTube is here.→。

On this occasion、With the expansion of personnel changes and Research、Newly started the recruitment of Assistant Professor (Adjunct) 1 person。Payroll will be determined according to the University rules。

Depending on the changes in the neural activity and the environment、It is selectively enhanced to attenuation particular synapse、Or they are newly formed and removed。This process not only is the basis processes of memory and learning、It has become apparent in recent years is the basis of the change in the connect mix in a variety of psychiatric disorders and developmental disorders。Our laboratory is、Such molecular basis of functional and morphological synaptic plasticity、We aim to elucidate the molecular biology, electrophysiology and behavioral biological。

As the field
１．Electrophysiological(Brain slices and in vivo) orImagingPeople with a strong background in the field
２．Molecular biology, morphologyPeople with a strong background in the field
I assume any of the。Taking advantage of each of the background、Let's by all means greatly developed from Japan synapse research together。Also I think you'll connect to the future of the step up to learn a new technique in the lab。

If you are interested, please prepare 1) CV with、 2) Research proposal、3) wrote two people Reference destination (name and contact information)、Kawasaki grapefruit research(name and contact information)Please apply to。For further questions, please contact them, too.。The recruitment will be closed as soon as personnel are found。It was closed。

Nozawa-kun, a freshman in the PhD course, has published hisvery first paper in "the Cerebellum."。As there are no antibodies that can be used for immunohistochemical staining、cellular and subcellular localization of Neuroligin-1 has been unclear。Nozawa-kun, together with Hayashi-san、generated a mouse line, in which an HA epitope tag was knocked in the neuroligin-1 gene、Using anti-HA antibody, Nozawa-kun has clarified cellular and sucellular localization of endogenous Neuroligin-1 in the cerebellum。

In good offices All of Keio University School of Medicine and biology classroom, Kajimura Professor、This year also from 2:00 July 14, Saturday, to the laboratory, which was intended for first-year medical school tours have been made。In spite prior to the test、Faculty of Science and Technology, two students + medical students 11 people took part in the eagerly lecture and practice。Some from this will expect to grow up to become a species that aspire to medical research in the future。Photos here（Updated on September2PageThere is also a)。