In the 155th BrainClub、We invited Dr. Thomas Chater from the RIKEN CBS Synaptic Plasticity and Circuit Regulation Research Team (2/15(Wed) 16:00~17:30）。The subject was "Towards a logic of homo- and heterosynaptic dynamics following plasticity」です。from recent research、A phenomenon called "Heterosynaptic plasticity" has been found in which plasticity occurs in neighboring synapses when a plasticity-inducing stimulus is applied to a specific synapse.。For Chater teacher this time、Observation of spine morphology and Ca using hippocampal slice culture and two-photon microscopy²⁺learned from imaging、He gave a lecture on interactions between spines that cause heterosynaptic plasticity.。Regarding the spatio-temporal control mode between synapses、A heated discussion took place, including unpublished data.。Commemorative photo @ seminar room with members of Yuzuzaki Lab after the lecture (upper photo)。In the center is Mr. Chater, the performer.。It was a raging BrainClub rush。Hope next time。(Press conference)

 University of California (UC Irvine, America)Dr. Kei Igarashi from、The 154th BrainClub was held (2/6(month) 17:30~19:00）。The title of the lecture was "Associative memory formation mechanism by dopamine and its failure in Alzheimer's disease"。The target is the formation and maintenance process of memory that is established based on olfactory information.、optogenetics andin vivoWe have clarified so far using electrophysiological techniques、He gave a lecture on the brain circuitry that controls memory.。Also、What kind of breakdown of brain circuit mechanism occurs in memory disorder of Alzheimer's disease?、Talk about the latest findings, including unpublished data.、A lively question-and-answer session ensued。

The above photo is a commemorative photo taken after the lecture.。In the center is Igarashi-sensei (next to Yuzuzaki-sensei)。A lot of "recruits" of Yuzuzaki Lab are also reflected。I was careless and the update didn't catch up、excuse me (interview)

Welcome Dr. Ingo Greger from MRC Molecular Biology Laboratory (UK)、1The 153rd BrainClub was held on Friday, March 20th.。The title is "Mechanisms underlying AMPA receptor modulation and synaptic localization"。AMPA receptors accumulated at postsynaptic sites play a central role in fast information transmission between neurons via excitatory synapses.。For Ingo-sensei this time、Clarified using cryo-electron microscopy and electrophysiological analysis、The functional control mechanism of AMPA receptors brought about by differences in constituent subunits and auxiliary subunits、Please tell us about your latest findings.、Lively discussions took place。

The photo above is a commemorative photo taken after the lecture@Yuzaki lab seminar room。Ingo-sensei is central。Next to Yuzuzaki-sensei。The Seminar room has become beautiful Yo (Conference)

Dr. Teruhiro Okuyama of the Institute for Quantitative Life Sciences, The University of Tokyo, visited us.、The 152nd BrainClub was held (12/23(Fri) 16:00~17:30）。The title of his presentation was "Neural Mechanisms of Social Memory in the Hippocampus"。How "social memory" is processed as information in the ventral hippocampus、Obtained using calcium imaging and optogenetics、He gave a lecture on the results of his research to date.。In addition, please introduce the latest data on the brain representation mechanism of life and death.、It was a lively time for discussion from beginning to end.、I thought it was good too.)。

The photo above is the usual after the lecture、Commemorative photo while holding my breath @Yuzuzaki Laboratory。Okuyama-sensei is next to Yuzuzaki-sensei.。I'll do my best to clean up~ Aye oh…(Press conference)

The 151st BrainClub presenters include:、We invited Dr. Takuya Sasaki from the Graduate School of Pharmaceutical Sciences, Tohoku University (Friday, July 15, 2022).、Face-to-face and web hybrid format)。heavy rain、Welcome to Keio University、He gave a lecture titled "Operating Principles of the Hippocampal Circuit Controlling Learning and Memory".。from the hippocampus and related brain regionsin vivoCan be deciphered from analysis results using multi-unit recording、Changes in neural activity during individual learning and memory、He talked about the research results obtained so far.。Also、Please also make a presentation on a new attempt to expand the recording target beyond the brain with the latest knowledge.、Lively discussions took place。

The photo is a commemorative photo taken after the lecture。Sasaki-sensei is in the center back row。Yuzusaki lab has many electrophysiology members。* There is no deep meaning in blurring the background (automatic adjustment of a certain Google smartphone used for trial)。After all, clean up a little ry (conference)

bioRxiv.  Posted May 29, 2022.

Plasticity-induced actin polymerization in the dendritic shaft regulates intracellular AMPA receptor trafficking

V. C. Wong, P.R. Houlihan, H. Liu, D. They passed by, M.C. DeSantis, Z. Liu, and E. C. O’Shea

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, 20147

doi: https://doi.org/10.1101/2022.05.29.493906

This article is a preprint and has not been certified by peer review.

※Paper printing"not recommended"

Brain Club 150th、Dr. Shogo Omae of Baylor College of Medicine gave a lecture on "Cerebellum Network Dynamics in Time Information Processing" (June 2, 2022).、web held)。Pressing for a review of the classical cerebellum computational principles、Regarding the new theory of "time information processing created by network dynamics of recurrent cerebellar circuits"、Experimental verification results using in vivo electrophysiology、About the dynamics generated from the artificial network model that imitates the cerebellar circuit、Lively discussions took place。

The commemorative photo is a screenshot of the PC screen (edited)。Looking at the camera ≠ Looking at the monitor?。even if、There is room for improvement in shooting timing control、Train the cerebellum (press conference)。

Invited Dr. Kenta Hagiwara of Allen Institute to the 149th Brain Club、Lecture on real-time online (April 27, 2022)。In addition to research results on neural circuit motifs that control the fear state of living things、Including the latest findings on the more general control of pleasant and unpleasant emotions、We had you discuss。Set in the new division "Allen Institute for Neural dynamics" of Allen, a new world、I'm looking forward to the future development of "In vivo physiology" (also a certain podcast?)。(Press conference)

The above image is a screenshot after the lecture、Hagiwara-sensei is the second from the left in the upper row (click the image to enlarge)。Excerpts from participants with camera ON。It may have overflowed off the screen due to the large number of participants.、Please pardon。* The secretariat is a "specification" that is not shown because it is a photographer.。

2/24 (Thur)、The 148th Brain Club was held、The 148th Brain Club was held。About the active role of glial cells in controlling brain function、About the active role of glial cells in controlling brain function、About the active role of glial cells in controlling brain function。How glial cells and nerve cells support (follow?) Each other、How glial cells and nerve cells support (follow?) Each other。

How glial cells and nerve cells support (follow?) Each other、How glial cells and nerve cells support (follow?) Each other、How glial cells and nerve cells support (follow?) Each other、With the students of Yuzuzaki Lab、How glial cells and nerve cells support (follow?) Each other

With the students of Yuzuzaki Lab。

The 147th Brain Club was held!、1The 147th Brain Club was held!。Technologies that enable efficient and quantitative analysis of continuous-section electron microscopic images、He gave a lecture on the interesting role of endoplasmic reticulum-mitochondria in nerve cells.。3D reconstruction using CLEM (video that is assembled on the xyz axis is cool)、One of the analyzes I would like to try in the future (press conference)。

One of the analyzes I would like to try in the future (press conference)

Nature. 2021 Oct;598(7881):489-494.
Hominini-specific regulation of CBLN2 increases prefrontal spinogenesis
Mikihito Shibata, Kartik Pattabiraman, Sydney K Muchnik, Navjot Kaur, Yury M Morozov, Xiaoyang Cheng, Stephen G Waxman & Nenad Sestan
PMID: 34599306

※Related article in the same issue
Nature. 2021 Oct;598(7881):483-488.
Regulation of prefrontal patterning and connectivity by retinoic acid
Mikihito Shibata, Kartik Pattabiraman, Belen Lorente-Galdos, David Andrijevic, Suel-Kee Kim, Navjot Kaur, Sydney K. Muchnik, Xiaojun Xing, Gabriel Santpere, Andre M. M. Sousa & Nenad Sestan
PMID: 34599305

bioRxiv. Posted March 25, 2021

Neural circuitry for maternal oxytocin release induced by infant cries

Silvana Valtcheva, Habon A. Issa, Kathleen A. Martin, Kanghoon Jung, Hyung-Bae Kwon and Robert C. Froemke

doi: https://doi.org/10.1101/2021.03.25.436883

This article is a preprint and has not been certified by peer review.