The work of Dr. Matsuda (Associate Professor, University of Electro-Communications, Visiting Associate Professor, Keio Physiology)has been accepted by J Biol Chem.。Congratulations!。

Long-term repression phenomenon (LTD), which is considered to be the basic course of memory and learning)Is the number of AMPA receptors in the postsynaptic、It is believed that its molecular level entity is reduced due to internalization (endocytosis) by neural activity.。By phosphorylating the intracellular domain, which is conventionally different for each subunit of AMPA receptor、It was thought that the endocytosis of the AMPA receptor itself was regulated。On the other hand、Phosphorylation of TARP that binds to AMPA receptor regardless of AMPA receptor subunit、From binding AP-2, which is essential for endocytosis, to the AMPA-TARP complex、It was a mystery how AMPA receptor subunits could control LTD.。In this paper、The phosphorylation status of the GluA1 subunit of the AMPA receptor、Discovered to change the strength of the bond between TARP and AP-2。Although TARP cannot distinguish the subunits of AMPA receptors、AP-2 can distinguish the phosphorylation state of each subunit of AMPA-TARP receptor.。

07/24/2021 6:01 PM | What's New