Ibata's paper、In Neuron magazine May 6, online version (US Eastern time 11:00).。Protein Cbln1 which has a function to create a new synapses、That is secreted from the lysosomes of nerve cells in response to neuronal activity、This study, which was revealed by the experiments using a mouse。
Lysosomes is、A cell organelles with enzymes that break down proteins、It plays a decomposition of no longer needed intracellular protein。Cbln1 was found to be present in the lysosome in the axons of nerve cells by this time of the study。Also, when the neural activity is enhanced、The contents of the lysosomes from axons that (a proteolytic enzyme and Cbln1) are both secreted out of the cells was found for the first time。From these experimental results、Destruction and synapse formation by Cbln1 extracellular environment by proteolytic enzymes、By working in concert、Possibility that the restructuring takes place in the synapse in response to neural activity is suggested。Synaptic reorganization is an entity of memory and learning、The failure have been reported in a number of mental illnesses and neurodevelopmental disorder、The results of this research are expected to lead to the development of understanding and new treatments for the normal development mechanism and these conditions。
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05/07/2019 12:00 AM | What's New