Kakegawa Assistant Professor of paper is now Accept the Journal of Neuroscience。

Delta 2 receptors、It is essential for synapse formation in the cerebellum、At the same time synaptic plasticity phenomena underlying course of motor learning (long-term depression：Controls LTD)。In other words、Delta receptor is a unique molecule that controls the functional synaptic plasticity and morphological synaptic plasticity。By our lab work so far、Delta 2 receptors、Although it belongs to ionotropic glutamate receptor family、It does not bind to glutamate、And it has been reported that does not function as an ion channel。

In this study the intracellular site of delta 2 receptors (C-terminal) is、It is essential for functional synaptic plasticity features such as LTD and motor learning (eyeblink conditioning)、On the other hand、The morphological synapse formation was the first time revealed that the C-terminus is not essential。In other words、Delta 2 receptors、Through the C-terminal controls the functional synaptic plasticity、Other sites、Probably involved in morphological synapse formation through the extracellular domain (N-terminal)、It is thought that each driving a separate signaling system。

12/20/2007 12:54 AM | What's New