A paper by Associate Kakegawa J Physiol (London)Now in press in。Congrats。

This paper、By L7 promoter、By mating transgenic mice and delta 2 receptor null mutant mice expressing specific delta receptor in Purkinje cells、The recovery degree of various phenotypes of null mutant mouse thing was electrophysiological and morphological study。

Surprisingly、Not only normal delta 2 receptor、Delta 2 receptor mutated Q / R site to determine the Ca permeability in the channel pore also、It found that to recover most of the phenotype。From this it、Delta 2 receptor is now clear that the amino acid sequence does not function as a Ca channel but is expected to form a Ca ion transmission channel pore of。

01/15/2007 12:49 AM | What's New