Keiko Matsuda lecturer and Tim Budisantoso kun is first author of the paper4Online version of Neuron of the month 28 days.。

Kainate receptors of the glutamate receptor、There was particularly high in specific synapses of the hippocampus, an important brain region in memory and learning、The transmission rate that is slow not to other receptors、And the essential role in the integration of hippocampal neural network activity。However、Whether incorporated only to certain synaptic kainate receptors what mechanism、The mechanism was not well understood。In this paper, the、By neurons secrete proteins called the C1ql2 and C1ql3、I found that coming to collect the kainate receptors directly。Also、In the hippocampus of mice lacking the C1ql2 and C1ql3、Kainate receptors is not incorporated into the synapse、Be less likely to occur epileptic seizures was found be given a stimulus to induce epileptic artificially。

C1ql2、C1ql3 is also present in various brain regions、Are considered each by controlling the built-in and function of kainate receptor synaptic neural make up the appropriate neural network activity。The results of this research、It is expected to be of use in the therapy method development and cause elucidation of epilepsy and autism。

This paper、As this month's attention paper of Neuron magazinePreview “Synaptic Menage a Trois”Was introduced as (ThreesomesPlease check out our own meaning of。）

04/29/2016 4:05 PM | What's New