The paper states, ``There is no evidence that GluD receptors act as ligand-gated ion channels.''Published in Proc Natl Acad Sci magazineit was done。
Delta receptors (GluD1 and GluD2)、A member of the ionotropic glutamate receptor family、plays a central role in many neurodevelopmental and psychiatric disorders。GluD is、Not related to ion channel activity、By forming a tripartite complex across synapses with the secreted synaptogenic molecules Cbln and neurexin (Nrxn).、Controls synapse formation and maturation。On the other hand、in recent years、Only when GluD2 forms the Nrxn/Cbln/GluD2 complex、It was reported that it functions as an ion channel that responds to D-serine and glycine.。Nozawa-kun, together with Hayashi-san、We、Currents induced by D-serine and glycine in ectopic cells and neurons、Proved that GluD is not directly involved as an ion channel。This finding is、It makes an important contribution to the ongoing discussion on the function of GluD.。In collaboration with Pierre Paoletti laboratory、Mr. Ito and Laura Piot acted as first authors.。

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