The 160th Brain Club welcomed Dr. Teruyoshi Nakagawa (Vanderbilt University), who was temporarily returning to Japan.。The title is "Visualizing putative ions and water molecules in the ion conduction path of the AMPA receptor"。AMPA receptors are responsible for rapid excitatory transmission in the central nervous system、Elucidation of its structure and function is an important theme that expands the possibility of clinical application as well as basic science.。Dr. Nakagawa uses cryo-EM to、2.3Ca by resolution reaching Ų⁺The structure of transmissive AMPA receptor has been clarified。Interestingly, when a highly conserved gate (SYTANLAAF) in the AMPA receptor opens upon channel opening,、Ca in the same area²⁺you have told me to join。Probably Na⁺Along with inhibiting the influx of other ions such as、efficient Ca²⁺It is considered a mechanism for achieving transparency.、We all listened with great interest.。

08/31/2023 9:15 PM | What's New