Interview-kun's paper "C1ql1-Bai3 signaling is necessary for climbing fiber synapse formation in mature Purkinje cells in coordination with neuronal activity” was published in Molecular Brain magazine。Cerebellar Purkinje cells form multiple climbing fibers and synapses when young、Unnecessary synapses are pruned during development, except for one climbing fiber。In this paper、climbing fiber：1 Purkinje cell：1Even in the mature cerebellum, which has established the control mode of、By increasing the expression of C1ql1 and Bai3、Purkinje cells create multiple climbing fibers and synapses again、Climbing fibers usually branch in the anterior-posterior direction,、Newly formed synapses originate from branches of climbing fibers that diverge in the medial-lateral direction、They discovered that the presence of electrical activity in climbing fibers and Purkinje cells is necessary for new synapse formation.。Even when the GluD2 glutamate receptor is knocked out after maturation,、It is known that the internal and external branches of multiple climbing fibers form synapses with Purkinje cells.、We also found that this phenomenon is also dependent on C1ql1-Bai3 signaling。

07/25/2023 1:32 PM | What's New