3On the 12th of the month, Yuzuzaki gave a final lecture, "Bridge Over Troubled Synapse: C1q protein、wheels、And then beyond"I did it。movieHere。

We then held a celebration of the resignation ceremony at the Meiji Memorial Museum.。Researchers who once again conducted research together in the lab、Maya Kono、technician、Secretaries、Furthermore, to all those involved in the Faculty of Medicine and Keio University.、We would like to express our sincere gratitude。

4From Monday onwards, I will be transferred to Keio University WPI-Bio2Q.、I was given the opportunity to continue my research under the Director Honda.。in recent years、.、schizophrenia、Many mental and neurological disorders such as autism spectrum disorders and developmental disorders、It is becoming increasingly thought to be a "synaptic disease" caused by synaptic abnormalities。Until now, I、We investigate how central nervous system synapses are formed and maintained.、Based on this knowledge, we have aimed to clarify the pathology of synaptic disease and develop treatment methods.。In WPI-Bio2Q、In addition to the central nervous system、Enteroinal nervous system、Autonomic nervous system、Peripheral nervous system、Furthermore, we will continue our research focusing on the synapse formation mechanism that connects these nervous systems with each organ.。With this approach、Understand the mechanism by which multiple organs connect to each other and maintain homeostasis、We hope to help you understand the pathology of diseases and develop new treatments。

Yuzuzaki is2024Uehara Prize in 2019Awarded、The award ceremony was held on March 11th.。It was a great opportunity to receive this award with Dr. Kamitori Hideki from Nagoya Institute of Technology, who has been doing joint research on Optogenetics Tools.。

The award-winning lecture will be available on YouTubeIt is listed in。Suddenly, the screen was pitch black and I was panicked.。

3It was held on the 7th of the monthThe 3rd Keio University WPI-Bio2Q International SymposiumAt the poster presentation held at、Graduate student Shiozaki won the Poster Award (first prize).。

Associate Professor Wataru Kakegawa was awarded the 2024 Tatsuji Nomura Award.、11The award ceremony was held on March 30th at Kitasato Auditorium.。congratulations。Dr. Tatsuji Nomura is the Chairman of the Central Research Institute for Experimental Animals.、Consistent as director from beginning to end、He devoted his life to establishing the animal experiment system that is essential for the development of medicine.。This award was established to honor the achievements of Dr. Akihiro, who has dedicated himself to the development of "in vivo experimental medicine."。The concurrent award recipient is Professor Yuki Kagotani of the Cancer Immunology Research Department, Institute of Advanced Medical Sciences.。

The 166th Brain Club was held on November 28, 2024。Dr. Yimin Zou (Professor), School of Biological Sciences, UCSD)We welcomed。The title of the presentation was "Role of planar polarity proteins in the formation", maintenance, and plasticity of glutamatergic synapses”。Dr. Zou Axonal Guidance、In particular, Wnt signals are used in the long axis (AP axis).、planar polarity(PCP)It was discovered that a group of genes that determine the function of axons。Interestingly, PCP molecules are not only involved in axonal extension.、It was discovered that it acts on synapse formation and maintenance.、At the seminar, we heard a very interesting talk about new research on the relationship between Alzheimer's disease and depression.。

Kazuya Nozawa, a graduate student of the Yuzaki lab (currently studying abroad at the Pascal Kaeser lab at Harvard Medical School), has been awarded the Prestegious Human Frontier Science Program Long-term Fellowship.。Congratulations!

165th Brain ClubCo-hosted with WPI-Bio2Qon October 30, 2024。Lecturer: Dr. Valentin Nägerl (Director), Institute of Anatomy and Cell Biology at the Medical Center of the University of Göttingen)We welcomed。The title of the presentation is "Super-resolution imaging of brain microanatomy"。Dr. Nägerl at Bordeaux University、Using STED microscopy, we have analyzed nanoscale structural changes associated with synaptic plasticity in real time.。in recent years、As a super-resolution observation technology for extracellular space、Super-resolution shadow imaging (SUSHI)was developed。This time, we listened to a very interesting talk about the technical aspects of super-resolution technology and new research applying SUSHI.。News on WPI-Bio2Q HPClick here. 2022。

The 164th Brain Club will be attended by Dr. Naoya Takahashi (IINS) on August 1, 2024., University of Bordeaux)。The title of the presentation is “Cortical tactile sensory processing – insights from mouse whiskers”。Modeled after the mouse primary sensory cortex、How is the threshold of tactile perception controlled by top down signals?、We also heard a very interesting story about how tool use is represented in the tactile cortex.。

The 47th Japan Neuroscience Conference (NEURO2024) was held from July 24th to 27th at the Fukuoka Convention Center.)At、Marin Shimizu, a fourth-year medical student, won the Junior Researcher Poster Award.。Congratulations! !

The paper states, ``There is no evidence that GluD receptors act as ligand-gated ion channels.''Published in Proc Natl Acad Sci magazineit was done。
Delta receptors (GluD1 and GluD2)、A member of the ionotropic glutamate receptor family、plays a central role in many neurodevelopmental and psychiatric disorders。GluD is、Not related to ion channel activity、By forming a tripartite complex across synapses with the secreted synaptogenic molecules Cbln and neurexin (Nrxn).、Controls synapse formation and maturation。On the other hand、in recent years、Only when GluD2 forms the Nrxn/Cbln/GluD2 complex、It was reported that it functions as an ion channel that responds to D-serine and glycine.。Nozawa-kun, together with Hayashi-san、We、Currents induced by D-serine and glycine in ectopic cells and neurons、Proved that GluD is not directly involved as an ion channel。This finding is、It makes an important contribution to the ongoing discussion on the function of GluD.。In collaboration with Pierre Paoletti laboratory、Mr. Ito and Laura Piot acted as first authors.。

kainate-type glutamate receptor (KAR)A paper on the function of synapse formation is available online.became。KAR is、through ionotropic and metabotropic effects.、Involved in various neuropsychiatric and neurological disorders。However、Compared to AMPA-type and NMDA-type glutamate receptors,、The biological properties of KARs remain unclear in many ways。In this research、K.A.R.、Completely separate from ion channels and metabotropic effects、We revealed that it acts as a synapse organizer that creates synapses themselves.。In joint research with the Juan Lerma laboratory in Spain.、Associate Professor Kakegawa and Ana Paternain are first authors。For Press releaseClick here. 。

A paper co-authored with Jaime de Juan-Sanz of the Sorbonne University in France was published.Published in Cell Reportsit was done。LGI1, like Cbln1, is a synaptogenic molecule that belongs to the class of "extracellular scaffold proteins."。On this occasion、Like Cbln1, LGI1 is also secreted in response to neural activity and promotes synapse formation.、It was also found that it suppresses glutamate release.。Interestingly, Cbln1 is tetanus toxin (TeNT)(VAMP1-3 independent)、Secreted by Syntaxin-4 and SNAP49-dependent SNAREs。In contrast, LGI1 secretion was partially inhibited by TeNT.、Because it does not depend on SNAP29、found to be released by separate SNARE complexes。Yuzaki Lab provided analysis technology for the SNARE complex developed by Ibata。